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Sep 30, 2023Vol.46 No.9, pp. 527~572

COVER PICTURE: Chronic obstructive pulmonary disease (COPD) is marked by airspace enlargement (emphysema) and small airway fibrosis, leading to airflow obstruction and eventual respiratory failure. Shown is a microphotograph of hematoxylin and eosin (H&E)-stained histological sections of the enlarged alveoli as an indicator of emphysema. Piao et al. (pp. 558-572) demonstrate that recombinant human hyaluronan and proteoglycan link protein 1 (rhHAPLN1) significantly reduces the extended airspaces of the emphysematous alveoli by increasing the levels of TGF-β receptor I and SIRT1/6, as a previously unrecognized mechanism in human alveolar epithelial cells, and consequently mitigates COPD.

Current Issue Volume 46, Number 9, September 2023

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Molecules and Cells is an international on-line open-access journal devoted to the advancement and dissemination of fundamental knowledge in all areas of biology. It was launched in 1990 and ISO abbreviation is 'Mol. Cells'. Reports on a broad range of topics of general interest to biologists are published. It is published on the last day of each month by the Korean Society for Molecular and Cellular Biology.

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