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Mol. Cells 2003; 16(2): 143-146
Published online January 1, 1970
© The Korean Society for Molecular and Cellular Biology
Nicotine Enhances Neovascularization and Promotes Tumor Growth
Solid tumors require vascularization for their growth. Bone marrow-derived endothelial progenitor cells participate in tumor angiogenesis. Here, we show that nicotine markedly accelerated growth of colon cancer cells inoculated subcutaneously in mice but had no effect on proliferation of carcinoma cells in vitro. We found that the tumor growth was associated with increased vascularization of the tumor and that bone marrow-derived cells contributed to the formation of the new blood vessels. Our findings show that nicotine promotes tumor growth, at least in part, by stimulating tumor-associated neovascularization.
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Research Article
Mol. Cells 2003; 16(2): 143-146
Published online October 31, 2003
Copyright © The Korean Society for Molecular and Cellular Biology.
Nicotine Enhances Neovascularization and Promotes Tumor Growth
Takeshi Natori, Masataka Sata, Miwa Washida, Yasunobu Hirata, Ryozo Nagai, Masatoshi Makuuchi
Abstract
Solid tumors require vascularization for their growth. Bone marrow-derived endothelial progenitor cells participate in tumor angiogenesis. Here, we show that nicotine markedly accelerated growth of colon cancer cells inoculated subcutaneously in mice but had no effect on proliferation of carcinoma cells in vitro. We found that the tumor growth was associated with increased vascularization of the tumor and that bone marrow-derived cells contributed to the formation of the new blood vessels. Our findings show that nicotine promotes tumor growth, at least in part, by stimulating tumor-associated neovascularization.
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