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Mol. Cells 2013; 35(6): 550-556

Published online May 16, 2013

https://doi.org/10.1007/s10059-013-0088-8

© The Korean Society for Molecular and Cellular Biology

Angiopoietin-1 Elicits Pro-Inflammatory Responses in Monocytes and Differentiating Macrophages

Seung Hyeok Seok, Jong-Ik Heo, Ji-Hye Hwang, Yi-Rang Na, Jang-Hyuk Yun, Eun Hui Lee, Jong-Wan Park, and Chung-Hyun Cho

Department of Pharmacology and Ischemic/Hypoxic Disease Institute, College of Medicine, Seoul National University, Seoul 110-799, Korea, 1Department of Microbiology and Immunology and Institute of Endemic Disease, 2Department of Physiology, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea

Received: March 19, 2013; Revised: April 20, 2013; Accepted: April 22, 2013

Abstract

The angiopoietin/Tie2 system is an important regulator of angiogenesis and inflammation. In addition to its functions in endothelial cells, Tie2 expression on non-endothelial cells allows for angiopoietin ligands to stimulate the cells. Although Ang1 is a strong Tie2 receptor agonist, little is known regarding the effect of Ang1 on non-endothelial cells, such as monocytes and macrophages. In this study, we found that Ang1 functionally binds to and stimulates monocytes via p38 and Erk1/2 phosphorylation. Ang1-mediated monocyte stimulation is associated with pro-inflammatory cytokine TNF-alpha expression. We also determined that Ang1 switched macrophage differentiation toward a pro-inflammatory phenotype, even in the presence of an anti-inflammatory mediator. These findings suggest that Ang1 plays a role in stimulating pro-inflammatory responses and could provide a new strategy by which to manage inflammatory responses.

Keywords angiopoietin, inflammation, macrophage, monocyte, Tie2

Article

Research Article

Mol. Cells 2013; 35(6): 550-556

Published online June 30, 2013 https://doi.org/10.1007/s10059-013-0088-8

Copyright © The Korean Society for Molecular and Cellular Biology.

Angiopoietin-1 Elicits Pro-Inflammatory Responses in Monocytes and Differentiating Macrophages

Seung Hyeok Seok, Jong-Ik Heo, Ji-Hye Hwang, Yi-Rang Na, Jang-Hyuk Yun, Eun Hui Lee, Jong-Wan Park, and Chung-Hyun Cho

Department of Pharmacology and Ischemic/Hypoxic Disease Institute, College of Medicine, Seoul National University, Seoul 110-799, Korea, 1Department of Microbiology and Immunology and Institute of Endemic Disease, 2Department of Physiology, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea

Received: March 19, 2013; Revised: April 20, 2013; Accepted: April 22, 2013

Abstract

The angiopoietin/Tie2 system is an important regulator of angiogenesis and inflammation. In addition to its functions in endothelial cells, Tie2 expression on non-endothelial cells allows for angiopoietin ligands to stimulate the cells. Although Ang1 is a strong Tie2 receptor agonist, little is known regarding the effect of Ang1 on non-endothelial cells, such as monocytes and macrophages. In this study, we found that Ang1 functionally binds to and stimulates monocytes via p38 and Erk1/2 phosphorylation. Ang1-mediated monocyte stimulation is associated with pro-inflammatory cytokine TNF-alpha expression. We also determined that Ang1 switched macrophage differentiation toward a pro-inflammatory phenotype, even in the presence of an anti-inflammatory mediator. These findings suggest that Ang1 plays a role in stimulating pro-inflammatory responses and could provide a new strategy by which to manage inflammatory responses.

Keywords: angiopoietin, inflammation, macrophage, monocyte, Tie2

Mol. Cells
Jan 31, 2023 Vol.46 No.1, pp. 1~67
COVER PICTURE
RNAs form diverse shapes and play multiple functions as central molecules of gene expression. In this special issue on RNA, seven minireviews illustrate how basic concepts and recent RNA biology findings are transformed into new and exciting RNA therapeutics.

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