Mol. Cells 2013; 35(4): 269-273
Published online April 30, 2013
https://doi.org/10.1007/s10059-013-0066-1
© The Korean Society for Molecular and Cellular Biology
Recently, graphene oxide (GO), one of the carbon nanomaterials, has received much attention due to its unique physical and chemical properties and high potential in many research areas including applications as biosensors and drug delivery vehicle. Various GO-based biosensors, largely based on its surface adsorption properties, have been developed not only for the detection of biomolecules including nucleotides and peptides, but also for the realtime monitoring of enzymatic reactions. In this review, we discuss recent advances of GO-based biosensors focusing on a novel assay platform for helicase activity, which was also employed for high-throughput screening to discover selective helicase inhibitors.
Keywords biosensor, drug screening, graphene oxide, helicase, hepatitis C
Mol. Cells 2013; 35(4): 269-273
Published online April 30, 2013 https://doi.org/10.1007/s10059-013-0066-1
Copyright © The Korean Society for Molecular and Cellular Biology.
Hongje Jang, Soo-Ryoon Ryoo, Min Jae Lee, Sang Woo Han, and Dal-Hee Min
Institute for Basic Science, Department of Chemistry, Seoul National University, Seoul 151-747, Korea, 1Center for Nanomaterials and Chemical Reactions, Institute for Basic Science, Department of Chemistry, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea, 2Department of Applied Chemistry, Kyung Hee University, Yongin 446-701, Korea
Recently, graphene oxide (GO), one of the carbon nanomaterials, has received much attention due to its unique physical and chemical properties and high potential in many research areas including applications as biosensors and drug delivery vehicle. Various GO-based biosensors, largely based on its surface adsorption properties, have been developed not only for the detection of biomolecules including nucleotides and peptides, but also for the realtime monitoring of enzymatic reactions. In this review, we discuss recent advances of GO-based biosensors focusing on a novel assay platform for helicase activity, which was also employed for high-throughput screening to discover selective helicase inhibitors.
Keywords: biosensor, drug screening, graphene oxide, helicase, hepatitis C
Jihoon Kim, and Won Do Heo
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