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Mol. Cells 2013; 35(4): 269-273

Published online April 30, 2013

https://doi.org/10.1007/s10059-013-0066-1

© The Korean Society for Molecular and Cellular Biology

A New Helicase Assay Based on Graphene Oxide for Anti-Viral Drug Development

Hongje Jang, Soo-Ryoon Ryoo, Min Jae Lee, Sang Woo Han, and Dal-Hee Min

Institute for Basic Science, Department of Chemistry, Seoul National University, Seoul 151-747, Korea, 1Center for Nanomaterials and Chemical Reactions, Institute for Basic Science, Department of Chemistry, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea, 2Department of Applied Chemistry, Kyung Hee University, Yongin 446-701, Korea

Received: February 25, 2013; Accepted: February 28, 2013

Abstract

Recently, graphene oxide (GO), one of the carbon nanomaterials, has received much attention due to its unique physical and chemical properties and high potential in many research areas including applications as biosensors and drug delivery vehicle. Various GO-based biosensors, largely based on its surface adsorption properties, have been developed not only for the detection of biomolecules including nucleotides and peptides, but also for the realtime monitoring of enzymatic reactions. In this review, we discuss recent advances of GO-based biosensors focusing on a novel assay platform for helicase activity, which was also employed for high-throughput screening to discover selective helicase inhibitors.

Keywords biosensor, drug screening, graphene oxide, helicase, hepatitis C

Article

Minireview

Mol. Cells 2013; 35(4): 269-273

Published online April 30, 2013 https://doi.org/10.1007/s10059-013-0066-1

Copyright © The Korean Society for Molecular and Cellular Biology.

A New Helicase Assay Based on Graphene Oxide for Anti-Viral Drug Development

Hongje Jang, Soo-Ryoon Ryoo, Min Jae Lee, Sang Woo Han, and Dal-Hee Min

Institute for Basic Science, Department of Chemistry, Seoul National University, Seoul 151-747, Korea, 1Center for Nanomaterials and Chemical Reactions, Institute for Basic Science, Department of Chemistry, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea, 2Department of Applied Chemistry, Kyung Hee University, Yongin 446-701, Korea

Received: February 25, 2013; Accepted: February 28, 2013

Abstract

Recently, graphene oxide (GO), one of the carbon nanomaterials, has received much attention due to its unique physical and chemical properties and high potential in many research areas including applications as biosensors and drug delivery vehicle. Various GO-based biosensors, largely based on its surface adsorption properties, have been developed not only for the detection of biomolecules including nucleotides and peptides, but also for the realtime monitoring of enzymatic reactions. In this review, we discuss recent advances of GO-based biosensors focusing on a novel assay platform for helicase activity, which was also employed for high-throughput screening to discover selective helicase inhibitors.

Keywords: biosensor, drug screening, graphene oxide, helicase, hepatitis C

Mol. Cells
Dec 31, 2021 Vol.44 No.12, pp. 861~919
COVER PICTURE
Structure of the fly peripheral neurons in the fly head. Flies have basic sensory organs including eyes for vision, antennae and maxillary palps for olfaction, and proboscis (magenta) for gustation which can be labelled with monoclonal antibody 22C10. The figure is a 3D reconstructed image with 30 slices of confocal sections with 3 μm interval. It shows that the proboscis is required for sensing attractive carboxylic acids such as glycolic acid, citric acid, and lactic acid (Shrestha and Lee, pp. 900-910).

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