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Mol. Cells 2012; 34(3): 219-229

Published online July 4, 2012

https://doi.org/10.1007/s10059-012-0058-6

© The Korean Society for Molecular and Cellular Biology

The Bloodline of CD8α+ Dendritic Cells

Suk-Jo Kang*

Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea

Correspondence to : *Correspondence: suk-jo.kang@kaist.ac.kr

Received: February 22, 2012; Revised: May 24, 2012; Accepted: May 25, 2012

Abstract

The immune system is highly coordinated by various cell types. Dendritic cells (DCs) orchestrate immune respon-ses at various stages and bridge innate immunity and adaptive immunity. DCs are a family of cells consisting of various subsets distinguished by surface markers, loca-tions, and transcription factors that govern their development, differentiation, and homeostasis. The complexity of DC subset biology has hindered the understanding of the functional differences among DC subsets. The subset expressing the surface molecule CD8alpha is of particular interest, due to the efficiency of this DC subset in priming CD8+ cytotoxic T cells and cross-presenting exogenous antigens to CD8+ T cells. CD8?+ DCs maintain tolerance to autologous antigens at steady state, but when activated secrete IL-12, polarizing T helper (Th) 1 responses. Recently, novel DC subsets were found to be present in peripheral tissues and the relationship between CD8alpha+ DCs in lymphoid organs and DC subsets in peripheral tissues has been revealed. This review describes the pedigree of CD8alpha+ DCs and related subsets, including a history of the discovery of DC subsets and their functional characterization.

Keywords CD103, CD8alpha, dendritic cells, langerin, subset

Article

Minireview

Mol. Cells 2012; 34(3): 219-229

Published online September 30, 2012 https://doi.org/10.1007/s10059-012-0058-6

Copyright © The Korean Society for Molecular and Cellular Biology.

The Bloodline of CD8α+ Dendritic Cells

Suk-Jo Kang*

Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea

Correspondence to:*Correspondence: suk-jo.kang@kaist.ac.kr

Received: February 22, 2012; Revised: May 24, 2012; Accepted: May 25, 2012

Abstract

The immune system is highly coordinated by various cell types. Dendritic cells (DCs) orchestrate immune respon-ses at various stages and bridge innate immunity and adaptive immunity. DCs are a family of cells consisting of various subsets distinguished by surface markers, loca-tions, and transcription factors that govern their development, differentiation, and homeostasis. The complexity of DC subset biology has hindered the understanding of the functional differences among DC subsets. The subset expressing the surface molecule CD8alpha is of particular interest, due to the efficiency of this DC subset in priming CD8+ cytotoxic T cells and cross-presenting exogenous antigens to CD8+ T cells. CD8?+ DCs maintain tolerance to autologous antigens at steady state, but when activated secrete IL-12, polarizing T helper (Th) 1 responses. Recently, novel DC subsets were found to be present in peripheral tissues and the relationship between CD8alpha+ DCs in lymphoid organs and DC subsets in peripheral tissues has been revealed. This review describes the pedigree of CD8alpha+ DCs and related subsets, including a history of the discovery of DC subsets and their functional characterization.

Keywords: CD103, CD8alpha, dendritic cells, langerin, subset

Mol. Cells
Jan 31, 2023 Vol.46 No.1, pp. 1~67
COVER PICTURE
RNAs form diverse shapes and play multiple functions as central molecules of gene expression. In this special issue on RNA, seven minireviews illustrate how basic concepts and recent RNA biology findings are transformed into new and exciting RNA therapeutics.

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