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Mol. Cells 2011; 31(4): 295-302

Published online February 25, 2011

https://doi.org/10.1007/s10059-011-0051-5

© The Korean Society for Molecular and Cellular Biology

Nanomaterials for Cancer Therapy and Imaging

Ki Hyun Bae, Hyun Jung Chung, and Tae Gwan Park*

Department of Biological Sciences and Graduate School of Nanoscience and Technology, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea

Correspondence to : *Correspondence: tgpark@kaist.ac.kr

Received: January 14, 2011; Revised: February 14, 2011; Accepted: February 14, 2011

Abstract

A variety of organic and inorganic nanomaterials with dimensions below several hundred nanometers are recently emerging as promising tools for cancer therapeutic and diagnostic applications due to their unique characteristics of passive tumor targeting. A wide range of nanomedicine platforms such as polymeric micelles, liposomes, dendrimers, and polymeric nanoparticles have been extensively explored for targeted delivery of anti-cancer agents, because they can accumulate in the solid tumor site via leaky tumor vascular structures, thereby selectively delivering therapeutic payloads into the desired tumor tissue. In recent years, nanoscale delivery vehicles for small interfering RNA (siRNA) have been also developed as effective therapeutic approaches to treat cancer. Furthermore, rationally designed multi-functional surface modification of these nanomaterials with cancer targeting moieties, protective polymers, and imaging agents can lead to fabrication versatile theragnostic nanosystems that allow simultaneous cancer therapy and diagnosis. This review highlights the current state and future prospects of diverse biomedical nanomaterials for cancer therapy and imaging.

Keywords cancer therapy, drug delivery system, imaging, nanoparticles, small interfering RNA

Article

Minireview

Mol. Cells 2011; 31(4): 295-302

Published online April 30, 2011 https://doi.org/10.1007/s10059-011-0051-5

Copyright © The Korean Society for Molecular and Cellular Biology.

Nanomaterials for Cancer Therapy and Imaging

Ki Hyun Bae, Hyun Jung Chung, and Tae Gwan Park*

Department of Biological Sciences and Graduate School of Nanoscience and Technology, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea

Correspondence to:*Correspondence: tgpark@kaist.ac.kr

Received: January 14, 2011; Revised: February 14, 2011; Accepted: February 14, 2011

Abstract

A variety of organic and inorganic nanomaterials with dimensions below several hundred nanometers are recently emerging as promising tools for cancer therapeutic and diagnostic applications due to their unique characteristics of passive tumor targeting. A wide range of nanomedicine platforms such as polymeric micelles, liposomes, dendrimers, and polymeric nanoparticles have been extensively explored for targeted delivery of anti-cancer agents, because they can accumulate in the solid tumor site via leaky tumor vascular structures, thereby selectively delivering therapeutic payloads into the desired tumor tissue. In recent years, nanoscale delivery vehicles for small interfering RNA (siRNA) have been also developed as effective therapeutic approaches to treat cancer. Furthermore, rationally designed multi-functional surface modification of these nanomaterials with cancer targeting moieties, protective polymers, and imaging agents can lead to fabrication versatile theragnostic nanosystems that allow simultaneous cancer therapy and diagnosis. This review highlights the current state and future prospects of diverse biomedical nanomaterials for cancer therapy and imaging.

Keywords: cancer therapy, drug delivery system, imaging, nanoparticles, small interfering RNA

Mol. Cells
Jan 31, 2023 Vol.46 No.1, pp. 1~67
COVER PICTURE
RNAs form diverse shapes and play multiple functions as central molecules of gene expression. In this special issue on RNA, seven minireviews illustrate how basic concepts and recent RNA biology findings are transformed into new and exciting RNA therapeutics.

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