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Mol. Cells 2010; 30(1): 1-12
Published online July 14, 2010
https://doi.org/10.1007/s10059-010-0105-0
© The Korean Society for Molecular and Cellular Biology
Reactive Oxygen Species in TNFalpha-Induced Signaling and Cell Death
Correspondence to : *Correspondence: zgliu@helix.nih.gov
TNFα is a pleotropic cytokine that initiates many down-stream signaling pathways, including NF-κB activation, MAP kinase activation and the induction of both apop-tosis and necrosis. TNFα has shown to lead to reactive oxygen species generation through activation of NADPH oxidase, through mitochondrial pathways, or other en-zymes. As discussed, ROS play a role in potentiation or inhibition of many of these signaling pathways. We par-ticularly discuss the role of sustained JNK activation potentiated by ROS, which generally is supportive of apoptosis and "necrotic cell death" through various mechanisms, while ROS could have inhibitory or stimulatory roles in NF-κB signaling.
Keywords JNK, necrotic cell death, NF-κB, ROS, TNFα
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Mol. Cells 2010; 30(1): 1-12
Published online July 31, 2010 https://doi.org/10.1007/s10059-010-0105-0
Copyright © The Korean Society for Molecular and Cellular Biology.
Reactive Oxygen Species in TNFalpha-Induced Signaling and Cell Death
Michael J. Morgan, and Zheng-gang Liu*
Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD 20892, USA
Correspondence to:*Correspondence: zgliu@helix.nih.gov
Abstract
TNFα is a pleotropic cytokine that initiates many down-stream signaling pathways, including NF-κB activation, MAP kinase activation and the induction of both apop-tosis and necrosis. TNFα has shown to lead to reactive oxygen species generation through activation of NADPH oxidase, through mitochondrial pathways, or other en-zymes. As discussed, ROS play a role in potentiation or inhibition of many of these signaling pathways. We par-ticularly discuss the role of sustained JNK activation potentiated by ROS, which generally is supportive of apoptosis and "necrotic cell death" through various mechanisms, while ROS could have inhibitory or stimulatory roles in NF-κB signaling.
Keywords: JNK, necrotic cell death, NF-κB, ROS, TNFα
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