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Research Article

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Mol. Cells 2010; 29(4): 355-361

Published online March 4, 2010

https://doi.org/10.1007/s10059-010-0038-7

© The Korean Society for Molecular and Cellular Biology

Identification and Characterization of CMTM4, a Novel Gene with Inhibitory Effects on HeLa Cell Growth through Inducing G2/M Phase Accumulation

Markus Plate, Ting Li, Yu Wang, Xiaoning Mo, Yingmei Zhang, Dalong Ma, and Wenling Han*

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Center for Human Disease Genomics, Department of Immunology, School of Basic Medical Science, Health Science Center, Peking University, Beijing 100191, China

Correspondence to : *Correspondence: hanwl@bjmu.edu.cn

Received: September 15, 2009; Revised: December 6, 2009; Accepted: December 7, 2009

Abstract

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Human CMTM is a novel gene family consisting of CKLF and CMTM1-8. CMTM4 is the most conserved gene and has three RNA splicing forms designated as CMTM4-v1, -v2 and -v3, but in many types of tissue and cell lines, only CMTM4-v1 and -v2 could be detected. CMTM4-v2 is the full length cDNA product, which has been highly conserved during evolution. CMTM4-v1 and -v2 are broadly expressed in normal types of tissue. They are distributed on the cell membrane and across the cytoplasm in a speckled pattern. Overexpression of CMTM4-v1 and -v2 can inhibit HeLa cell growth via G2/M phase accumulation without inducing apoptosis. Therefore, CMTM4 might be an important gene involved in cell growth and cell cycle regulation.

Keywords apoptosis, cell cycle, cell growth, CMTM4, MARVEL

Article

Research Article

Mol. Cells 2010; 29(4): 355-361

Published online March 4, 2010 https://doi.org/10.1007/s10059-010-0038-7

Copyright © The Korean Society for Molecular and Cellular Biology.

Identification and Characterization of CMTM4, a Novel Gene with Inhibitory Effects on HeLa Cell Growth through Inducing G2/M Phase Accumulation

Markus Plate, Ting Li, Yu Wang, Xiaoning Mo, Yingmei Zhang, Dalong Ma, and Wenling Han*

Center for Human Disease Genomics, Department of Immunology, School of Basic Medical Science, Health Science Center, Peking University, Beijing 100191, China

Correspondence to:*Correspondence: hanwl@bjmu.edu.cn

Received: September 15, 2009; Revised: December 6, 2009; Accepted: December 7, 2009

Abstract

Human CMTM is a novel gene family consisting of CKLF and CMTM1-8. CMTM4 is the most conserved gene and has three RNA splicing forms designated as CMTM4-v1, -v2 and -v3, but in many types of tissue and cell lines, only CMTM4-v1 and -v2 could be detected. CMTM4-v2 is the full length cDNA product, which has been highly conserved during evolution. CMTM4-v1 and -v2 are broadly expressed in normal types of tissue. They are distributed on the cell membrane and across the cytoplasm in a speckled pattern. Overexpression of CMTM4-v1 and -v2 can inhibit HeLa cell growth via G2/M phase accumulation without inducing apoptosis. Therefore, CMTM4 might be an important gene involved in cell growth and cell cycle regulation.

Keywords: apoptosis, cell cycle, cell growth, CMTM4, MARVEL

Mol. Cells
Mar 31, 2023 Vol.46 No.3, pp. 131~189
COVER PICTURE
The physiologically important cytoprotective signaling in normal cells (background area in turquoise) mediated by NRF2 (blue chain) is often hijacked by cancer cells (red ball) in the tumor microenvironment (yellow area). However, the differential roles of NRF2 throughout the multistage carcinogenesis remains largely unresolved (white-colored overlapping misty areas).
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