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Mol. Cells 2009; 28(4): 315-320

Published online October 31, 2009

https://doi.org/10.1007/s10059-009-0143-7

© The Korean Society for Molecular and Cellular Biology

Non-Redundancy within the RAS Oncogene Family: Insights into Mutational Disparities inCancer

Ken S. Lau, and Kevin M. Haigis

Received: September 8, 2009; Accepted: September 11, 2009

Abstract

The RAS family of oncoproteins has been studied exten-sively for almost three decades. While we know that activation of RAS represents a key feature of malignant transformation for many cancers, we are only now beginning to understand the complex underpinnings of RAS biology. Here, we will discuss emerging cancer genome sequencing data in the context of what is currently known about RAS function. Taken together, retrospective studies of primary human tissues and prospective studies of experimental models support the notion that the variable mutation frequencies exhibited by the RAS oncogenes reflect unique functions of the RAS oncoproteins.

Keywords cancer, mutation, RAS, signaling

Article

Minireview

Mol. Cells 2009; 28(4): 315-320

Published online October 31, 2009 https://doi.org/10.1007/s10059-009-0143-7

Copyright © The Korean Society for Molecular and Cellular Biology.

Non-Redundancy within the RAS Oncogene Family: Insights into Mutational Disparities inCancer

Ken S. Lau, and Kevin M. Haigis

Received: September 8, 2009; Accepted: September 11, 2009

Abstract

The RAS family of oncoproteins has been studied exten-sively for almost three decades. While we know that activation of RAS represents a key feature of malignant transformation for many cancers, we are only now beginning to understand the complex underpinnings of RAS biology. Here, we will discuss emerging cancer genome sequencing data in the context of what is currently known about RAS function. Taken together, retrospective studies of primary human tissues and prospective studies of experimental models support the notion that the variable mutation frequencies exhibited by the RAS oncogenes reflect unique functions of the RAS oncoproteins.

Keywords: cancer, mutation, RAS, signaling

Mol. Cells
Dec 31, 2021 Vol.44 No.12, pp. 861~919
COVER PICTURE
Structure of the fly peripheral neurons in the fly head. Flies have basic sensory organs including eyes for vision, antennae and maxillary palps for olfaction, and proboscis (magenta) for gustation which can be labelled with monoclonal antibody 22C10. The figure is a 3D reconstructed image with 30 slices of confocal sections with 3 μm interval. It shows that the proboscis is required for sensing attractive carboxylic acids such as glycolic acid, citric acid, and lactic acid (Shrestha and Lee, pp. 900-910).

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