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Mol. Cells 2009; 27(2): 135-142

Published online February 20, 2009

https://doi.org/10.1007/s10059-009-0017-z

© The Korean Society for Molecular and Cellular Biology

Ab ovo or de novo? Mechanisms of Centriole Duplication

Jadranka Loncarek, Alexey Khodjakov

Received: December 22, 2009; Accepted: December 26, 2009

Abstract

The centrosome, an organelle comprising centrioles and associated pericentriolar material, is the major microtubule organizing center in animal cells. For the cell to form a bipolar mitotic spindle and ensure proper chromosome segregation at the end of each cell cycle, it is paramount that the cell contains two and only two centrosomes. Because the number of centrosomes in the cell is determined by the number of centrioles, cells have evolved elaborate mechanisms to control centriole biogenesis and to tightly coordinate this process with DNA replication. Here we review key proteins involved in centriole assembly, compare two major modes of centriole biogenesis, and discuss the mechanisms that ensure stringency of centriole number.

Keywords centriole, centrosome, duplication, de novo

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Mol. Cells 2009; 27(2): 135-142

Published online February 28, 2009 https://doi.org/10.1007/s10059-009-0017-z

Copyright © The Korean Society for Molecular and Cellular Biology.

Ab ovo or de novo? Mechanisms of Centriole Duplication

Jadranka Loncarek, Alexey Khodjakov

Received: December 22, 2009; Accepted: December 26, 2009

Abstract

The centrosome, an organelle comprising centrioles and associated pericentriolar material, is the major microtubule organizing center in animal cells. For the cell to form a bipolar mitotic spindle and ensure proper chromosome segregation at the end of each cell cycle, it is paramount that the cell contains two and only two centrosomes. Because the number of centrosomes in the cell is determined by the number of centrioles, cells have evolved elaborate mechanisms to control centriole biogenesis and to tightly coordinate this process with DNA replication. Here we review key proteins involved in centriole assembly, compare two major modes of centriole biogenesis, and discuss the mechanisms that ensure stringency of centriole number.

Keywords: centriole, centrosome, duplication, de novo

Mol. Cells
Sep 30, 2023 Vol.46 No.9, pp. 527~572
COVER PICTURE
Chronic obstructive pulmonary disease (COPD) is marked by airspace enlargement (emphysema) and small airway fibrosis, leading to airflow obstruction and eventual respiratory failure. Shown is a microphotograph of hematoxylin and eosin (H&E)-stained histological sections of the enlarged alveoli as an indicator of emphysema. Piao et al. (pp. 558-572) demonstrate that recombinant human hyaluronan and proteoglycan link protein 1 (rhHAPLN1) significantly reduces the extended airspaces of the emphysematous alveoli by increasing the levels of TGF-β receptor I and SIRT1/6, as a previously unrecognized mechanism in human alveolar epithelial cells, and consequently mitigates COPD.

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