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Mol. Cells 2009; 27(2): 135-142

Published online February 20, 2009

https://doi.org/10.1007/s10059-009-0017-z

© The Korean Society for Molecular and Cellular Biology

Ab ovo or de novo? Mechanisms of Centriole Duplication

Jadranka Loncarek, Alexey Khodjakov

Received: December 22, 2009; Accepted: December 26, 2009

Abstract

The centrosome, an organelle comprising centrioles and associated pericentriolar material, is the major microtubule organizing center in animal cells. For the cell to form a bipolar mitotic spindle and ensure proper chromosome segregation at the end of each cell cycle, it is paramount that the cell contains two and only two centrosomes. Because the number of centrosomes in the cell is determined by the number of centrioles, cells have evolved elaborate mechanisms to control centriole biogenesis and to tightly coordinate this process with DNA replication. Here we review key proteins involved in centriole assembly, compare two major modes of centriole biogenesis, and discuss the mechanisms that ensure stringency of centriole number.

Keywords centriole, centrosome, duplication, de novo

Article

Minireview

Mol. Cells 2009; 27(2): 135-142

Published online February 28, 2009 https://doi.org/10.1007/s10059-009-0017-z

Copyright © The Korean Society for Molecular and Cellular Biology.

Ab ovo or de novo? Mechanisms of Centriole Duplication

Jadranka Loncarek, Alexey Khodjakov

Received: December 22, 2009; Accepted: December 26, 2009

Abstract

The centrosome, an organelle comprising centrioles and associated pericentriolar material, is the major microtubule organizing center in animal cells. For the cell to form a bipolar mitotic spindle and ensure proper chromosome segregation at the end of each cell cycle, it is paramount that the cell contains two and only two centrosomes. Because the number of centrosomes in the cell is determined by the number of centrioles, cells have evolved elaborate mechanisms to control centriole biogenesis and to tightly coordinate this process with DNA replication. Here we review key proteins involved in centriole assembly, compare two major modes of centriole biogenesis, and discuss the mechanisms that ensure stringency of centriole number.

Keywords: centriole, centrosome, duplication, de novo

Mol. Cells
Jan 31, 2023 Vol.46 No.1, pp. 1~67
COVER PICTURE
RNAs form diverse shapes and play multiple functions as central molecules of gene expression. In this special issue on RNA, seven minireviews illustrate how basic concepts and recent RNA biology findings are transformed into new and exciting RNA therapeutics.

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