Mol. Cells 2008; 26(5): 415-426
Published online November 30, 2008
© The Korean Society for Molecular and Cellular Biology
The interactions between the host and microbial pathogen largely dictate the onset, progression, and outcome of infectious diseases. Pathogens subvert host components to promote their pathogenesis and, among these, cell surface heparan sulfate proteoglycans are exploited by many pathogens for their initial attachment and subsequent cellular entry. The ability to interact with heparan sulfate proteoglycans is widespread among viruses, bacteria, and parasites. Certain pathogens also use heparan sulfate proteoglycans to evade host defense mechanisms. These findings suggest that heparan sulfate proteoglycans are critical in microbial pathogenesis, and that heparan sulfate proteoglycan-pathogen interactions are potential targets for novel prophylactic and therapeutic approaches.
Keywords host defense, microbial pathogenesis, proteoglycan, syndecan, virulence factor, adhesin, cellular entry, heparan sulfate
Mol. Cells 2008; 26(5): 415-426
Published online November 30, 2008
Copyright © The Korean Society for Molecular and Cellular Biology.
Ye Chen, Martin Goette, Jian Liu and Pyong Woo Park
The interactions between the host and microbial pathogen largely dictate the onset, progression, and outcome of infectious diseases. Pathogens subvert host components to promote their pathogenesis and, among these, cell surface heparan sulfate proteoglycans are exploited by many pathogens for their initial attachment and subsequent cellular entry. The ability to interact with heparan sulfate proteoglycans is widespread among viruses, bacteria, and parasites. Certain pathogens also use heparan sulfate proteoglycans to evade host defense mechanisms. These findings suggest that heparan sulfate proteoglycans are critical in microbial pathogenesis, and that heparan sulfate proteoglycan-pathogen interactions are potential targets for novel prophylactic and therapeutic approaches.
Keywords: host defense, microbial pathogenesis, proteoglycan, syndecan, virulence factor, adhesin, cellular entry, heparan sulfate
Seoung Youn Won, and Ho Min Kim
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