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Mol. Cells 2008; 26(2): 171-174

Published online January 1, 1970

© The Korean Society for Molecular and Cellular Biology

Inhibition of Developmental Processes by Flavone in Caenorhabditis elegans and Its Application to the Pinewood Nematode, Bursaphelenchus xylophilus

Yong-Uk Lee, Ichiro Kawasaki, Yoongho Lim, Wan-Suk Oh, Young-Ki Paik, and Yhong-Hee Shim

Abstract

Flavone (2-phenyl chromone) is a well-known plant flavonoid, but its bioactivity has been little explored. Treatment of Caenorhabditis elegans or C. brissage with flavones induced embryonic and larval lethality that was pronounced in early larval stages. This anti-nematodal effect was also observed in the pinewood nematode, B. xylophilus. LD50 values were approximately 100 mM for both B. xylophilus and C. elegans. Our results indicate that flavone is an active nematicidal compound that should be further investigated with the aim of developing a potent drug against B. xylophilus.

Keywords Anti-Nematodal activity, bursaphelenchus xylophilus, caenorhabditis elegans, caenorhabditis briggsae, embryonic lethality, flavone (2-phenyl chromone), larval lethality

Article

Research Article

Mol. Cells 2008; 26(2): 171-174

Published online August 31, 2008

Copyright © The Korean Society for Molecular and Cellular Biology.

Inhibition of Developmental Processes by Flavone in Caenorhabditis elegans and Its Application to the Pinewood Nematode, Bursaphelenchus xylophilus

Yong-Uk Lee, Ichiro Kawasaki, Yoongho Lim, Wan-Suk Oh, Young-Ki Paik, and Yhong-Hee Shim

Abstract

Flavone (2-phenyl chromone) is a well-known plant flavonoid, but its bioactivity has been little explored. Treatment of Caenorhabditis elegans or C. brissage with flavones induced embryonic and larval lethality that was pronounced in early larval stages. This anti-nematodal effect was also observed in the pinewood nematode, B. xylophilus. LD50 values were approximately 100 mM for both B. xylophilus and C. elegans. Our results indicate that flavone is an active nematicidal compound that should be further investigated with the aim of developing a potent drug against B. xylophilus.

Keywords: Anti-Nematodal activity, bursaphelenchus xylophilus, caenorhabditis elegans, caenorhabditis briggsae, embryonic lethality, flavone (2-phenyl chromone), larval lethality

Mol. Cells
May 31, 2023 Vol.46 No.5, pp. 259~328
COVER PICTURE
The alpha-helices in the lamin filaments are depicted as coils, with different subdomains distinguished by various colors. Coil 1a is represented by magenta, coil 1b by yellow, L2 by green, coil 2a by white, coil 2b by brown, stutter by cyan, coil 2c by dark blue, and the lamin Ig-like domain by grey. In the background, cells are displayed, with the cytosol depicted in green and the nucleus in blue (Ahn et al., pp. 309-318).

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Molecules and Cells

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