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Mol. Cells 2007; 23(2): 123-131
Published online January 1, 1970
© The Korean Society for Molecular and Cellular Biology
Heat Shock Responses for Understanding Diseases of Protein Denaturation
Extracellular stresses induce heat shock response and render cells resistant to lethal stresses. Heat shock response involves induction of heat shock proteins (Hsps). Recently the roles of Hsps in neurodegenerative diseases and cancer are attracting increasing attention and have accelerated the study of heat shock response mechanism. This review focuses on the stress sensing steps, molecules involved in Hsps production, diseases related to Hsp malfunctions, and the potential of proteomics as a tool for understanding the complex signaling pathways relevant to these events.
Keywords Heat Shock Factor; Heat Shock Protein;, Heat Shock Response; MAPK; Misfolding of Protein; ROS;, Ubiquitin-Proteasome System
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Mol. Cells 2007; 23(2): 123-131
Published online April 30, 2007
Copyright © The Korean Society for Molecular and Cellular Biology.
Heat Shock Responses for Understanding Diseases of Protein Denaturation
Hee-Jung Kim, Na Rae Hwang, Kong-Joo Lee
Abstract
Extracellular stresses induce heat shock response and render cells resistant to lethal stresses. Heat shock response involves induction of heat shock proteins (Hsps). Recently the roles of Hsps in neurodegenerative diseases and cancer are attracting increasing attention and have accelerated the study of heat shock response mechanism. This review focuses on the stress sensing steps, molecules involved in Hsps production, diseases related to Hsp malfunctions, and the potential of proteomics as a tool for understanding the complex signaling pathways relevant to these events.
Keywords: Heat Shock Factor, Heat Shock Protein,, Heat Shock Response, MAPK, Misfolding of Protein, ROS,, Ubiquitin-Proteasome System
