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Research Article

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Mol. Cells 2009; 27(5): 571-575

Published online May 15, 2009

https://doi.org/10.1007/s10059-009-0075-2

© The Korean Society for Molecular and Cellular Biology

ATG5 Expression Induced by MDMA (Ecstasy), Interferes with Neuronal Differentiation of Neuroblastoma Cells

Myounghee Chae, Gyu-Seek Rhee, Ik-Soon Jang, Kwangsoo Kim, Ji-Hae Lee, Seung-Yeul Lee, Minjung Kim, Junyoung Yang, Junsoo Park, and Seung-Hoon Lee

Received: February 2, 2009; Revised: March 13, 2009; Accepted: March 23, 2009

Abstract

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The amphetamine derivative 3, 4-methylenedioxymetham- phetamine (MDMA) has become a popular recreational drug, and has also been shown to cause serotonergic neurotoxicity. This report shows that MDMA impairs brain development in a whole mouse embryo culture. The results of quantitative real-time PCR analysis showed that autophagy-related protein 5 (Atg5) expression is elevated in mouse embryo and neuroblas-toma cells after MDMA treatment. This elevated Atg5 expression interferes with the neuronal differentiation of neuroblastoma cells such as SH-SY5Y and PC12 cells. Thus, our results suggest that the use of MDMA during pregnancy may impair neuronal development via an induction of Atg5 expression.

Keywords Atg5, autophagy, MDMA, neuron, PC12, SH-SY5Y

Article

Research Article

Mol. Cells 2009; 27(5): 571-575

Published online May 31, 2009 https://doi.org/10.1007/s10059-009-0075-2

Copyright © The Korean Society for Molecular and Cellular Biology.

ATG5 Expression Induced by MDMA (Ecstasy), Interferes with Neuronal Differentiation of Neuroblastoma Cells

Myounghee Chae, Gyu-Seek Rhee, Ik-Soon Jang, Kwangsoo Kim, Ji-Hae Lee, Seung-Yeul Lee, Minjung Kim, Junyoung Yang, Junsoo Park, and Seung-Hoon Lee

Received: February 2, 2009; Revised: March 13, 2009; Accepted: March 23, 2009

Abstract

The amphetamine derivative 3, 4-methylenedioxymetham- phetamine (MDMA) has become a popular recreational drug, and has also been shown to cause serotonergic neurotoxicity. This report shows that MDMA impairs brain development in a whole mouse embryo culture. The results of quantitative real-time PCR analysis showed that autophagy-related protein 5 (Atg5) expression is elevated in mouse embryo and neuroblas-toma cells after MDMA treatment. This elevated Atg5 expression interferes with the neuronal differentiation of neuroblastoma cells such as SH-SY5Y and PC12 cells. Thus, our results suggest that the use of MDMA during pregnancy may impair neuronal development via an induction of Atg5 expression.

Keywords: Atg5, autophagy, MDMA, neuron, PC12, SH-SY5Y

Mol. Cells
Dec 31, 2023 Vol.46 No.12, pp. 727~777
COVER PICTURE
Lee et al. (pp. 757-763), show that disruption of ANKS1A promotes the entry of intraflagellar transport trains into cilia, increasing protein transport and forming extracellular vesicles (ECVs). This figure illustrates the abundance of ECVs along the cilia of primary ependymal cells derived from ANKS1A KO mice.
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