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Mol. Cells 1991; 1(4): 381-384

Published online December 31, 1991

© The Korean Society for Molecular and Cellular Biology

Protein-Protein Communications within the Transcription Apparatus

Akira Ishihama

Department of Molecular Genetics, National Institute of Genetics. and School of Life Science, Graduate University of Advanced Studies, Mishima, Shizuoka 411, Japan

Abstract

Gene transcription is regulated by controlling either the promoter activity of the DNA template or the promoter selectivity of RNA polymerase. A number of regulatory proteins are involved in these processes, which bind to either the transcription signals on DNA or the RNA polymerase. Several lines of evidence indicate that many DNA-binding transcription factors also exert their regulatory functions through interaction with the RNA polymerase after they bind to the DNA. The molecular communication between RNA polymerase and transcription factors is therefore a key element in the determination of promoter selection pattern, irrespective of apparent differences in the mechanism of promoter-RNA polymerase-transcription factor ternary complex formation. The variation in transcription rate between genes within a single cell is thus determined by the intracellular levels of individual transcription factors.

Article

Minireview

Mol. Cells 1991; 1(4): 381-384

Published online December 31, 1991

Copyright © The Korean Society for Molecular and Cellular Biology.

Protein-Protein Communications within the Transcription Apparatus

Akira Ishihama

Department of Molecular Genetics, National Institute of Genetics. and School of Life Science, Graduate University of Advanced Studies, Mishima, Shizuoka 411, Japan

Abstract

Gene transcription is regulated by controlling either the promoter activity of the DNA template or the promoter selectivity of RNA polymerase. A number of regulatory proteins are involved in these processes, which bind to either the transcription signals on DNA or the RNA polymerase. Several lines of evidence indicate that many DNA-binding transcription factors also exert their regulatory functions through interaction with the RNA polymerase after they bind to the DNA. The molecular communication between RNA polymerase and transcription factors is therefore a key element in the determination of promoter selection pattern, irrespective of apparent differences in the mechanism of promoter-RNA polymerase-transcription factor ternary complex formation. The variation in transcription rate between genes within a single cell is thus determined by the intracellular levels of individual transcription factors.

Mol. Cells
Nov 30, 2021 Vol.44 No.11, pp. 781~860
COVER PICTURE
3D quantitative images of the vesicular structure and the nucleolus using label free optical diffraction tomography (Kim et al., pp. 851-860).

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