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Mol. Cells 1991; 1(4): 381-384

Published online December 31, 1991

© The Korean Society for Molecular and Cellular Biology

Protein-Protein Communications within the Transcription Apparatus

Akira Ishihama

Department of Molecular Genetics, National Institute of Genetics. and School of Life Science, Graduate University of Advanced Studies, Mishima, Shizuoka 411, Japan

Abstract

Gene transcription is regulated by controlling either the promoter activity of the DNA template or the promoter selectivity of RNA polymerase. A number of regulatory proteins are involved in these processes, which bind to either the transcription signals on DNA or the RNA polymerase. Several lines of evidence indicate that many DNA-binding transcription factors also exert their regulatory functions through interaction with the RNA polymerase after they bind to the DNA. The molecular communication between RNA polymerase and transcription factors is therefore a key element in the determination of promoter selection pattern, irrespective of apparent differences in the mechanism of promoter-RNA polymerase-transcription factor ternary complex formation. The variation in transcription rate between genes within a single cell is thus determined by the intracellular levels of individual transcription factors.

Article

Minireview

Mol. Cells 1991; 1(4): 381-384

Published online December 31, 1991

Copyright © The Korean Society for Molecular and Cellular Biology.

Protein-Protein Communications within the Transcription Apparatus

Akira Ishihama

Department of Molecular Genetics, National Institute of Genetics. and School of Life Science, Graduate University of Advanced Studies, Mishima, Shizuoka 411, Japan

Abstract

Gene transcription is regulated by controlling either the promoter activity of the DNA template or the promoter selectivity of RNA polymerase. A number of regulatory proteins are involved in these processes, which bind to either the transcription signals on DNA or the RNA polymerase. Several lines of evidence indicate that many DNA-binding transcription factors also exert their regulatory functions through interaction with the RNA polymerase after they bind to the DNA. The molecular communication between RNA polymerase and transcription factors is therefore a key element in the determination of promoter selection pattern, irrespective of apparent differences in the mechanism of promoter-RNA polymerase-transcription factor ternary complex formation. The variation in transcription rate between genes within a single cell is thus determined by the intracellular levels of individual transcription factors.

Mol. Cells
Dec 31, 2021 Vol.44 No.12, pp. 861~919
COVER PICTURE
Structure of the fly peripheral neurons in the fly head. Flies have basic sensory organs including eyes for vision, antennae and maxillary palps for olfaction, and proboscis (magenta) for gustation which can be labelled with monoclonal antibody 22C10. The figure is a 3D reconstructed image with 30 slices of confocal sections with 3 μm interval. It shows that the proboscis is required for sensing attractive carboxylic acids such as glycolic acid, citric acid, and lactic acid (Shrestha and Lee, pp. 900-910).

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