TOP

Minireview

Split Viewer

Mol. Cells 2008; 26(1): 1-4

Published online January 1, 1970

© The Korean Society for Molecular and Cellular Biology

Training Molecularly Enabled Field Biologists to Understand Organism-Level Gene Function

Jin-Ho Kang and Ian T. Baldwin

Abstract

A gene’s influence on an organism’s Darwinian fitness ultimately determines whether it will be lost, maintained or modified by natural selection, yet biologists have few gene expression systems in which to measure whole-organism gene function. In the Department of Molecular Ecology at the Max Planck Institute for Chemical Ecology we are training “molecularly enabled field biologists” to use transformed plants silenced in the expression of environmentally regulated genes and the plant’s native habitats as “laboratories.” Research done in these natural laboratories will, we hope, increase our understanding of the function of genes at the level of the organism. Examples of the role of threonine deaminase and RNA-directed RNA polymerases illustrate the process.

Keywords Jasmonic Acid Signaling, Natural Selection, Threonine Deaminase, Darwinian Fitness, Direct Defenses, Indirect Defenses

Article

Minireview

Mol. Cells 2008; 26(1): 1-4

Published online July 31, 2008

Copyright © The Korean Society for Molecular and Cellular Biology.

Training Molecularly Enabled Field Biologists to Understand Organism-Level Gene Function

Jin-Ho Kang and Ian T. Baldwin

Abstract

A gene’s influence on an organism’s Darwinian fitness ultimately determines whether it will be lost, maintained or modified by natural selection, yet biologists have few gene expression systems in which to measure whole-organism gene function. In the Department of Molecular Ecology at the Max Planck Institute for Chemical Ecology we are training “molecularly enabled field biologists” to use transformed plants silenced in the expression of environmentally regulated genes and the plant’s native habitats as “laboratories.” Research done in these natural laboratories will, we hope, increase our understanding of the function of genes at the level of the organism. Examples of the role of threonine deaminase and RNA-directed RNA polymerases illustrate the process.

Keywords: Jasmonic Acid Signaling, Natural Selection, Threonine Deaminase, Darwinian Fitness, Direct Defenses, Indirect Defenses

Mol. Cells
Sep 30, 2023 Vol.46 No.9, pp. 527~572
COVER PICTURE
Chronic obstructive pulmonary disease (COPD) is marked by airspace enlargement (emphysema) and small airway fibrosis, leading to airflow obstruction and eventual respiratory failure. Shown is a microphotograph of hematoxylin and eosin (H&E)-stained histological sections of the enlarged alveoli as an indicator of emphysema. Piao et al. (pp. 558-572) demonstrate that recombinant human hyaluronan and proteoglycan link protein 1 (rhHAPLN1) significantly reduces the extended airspaces of the emphysematous alveoli by increasing the levels of TGF-β receptor I and SIRT1/6, as a previously unrecognized mechanism in human alveolar epithelial cells, and consequently mitigates COPD.

Share this article on

  • line

Molecules and Cells

eISSN 0219-1032
qr-code Download