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Mol. Cells 2003; 16(1): 106-112
Published online January 1, 1970
© The Korean Society for Molecular and Cellular Biology
Intraperitoneal Delivery of Cholera Toxin B Subunit Enhances Systemic and Mucosal Antibody Responses
Although cholera toxin (CT) is a potent mucosal adjuvant, its activity in systemic immunity is relatively undocumented. In the present study, we investigated its adjuvant effect on systemic and mucosal antibody responses following intraperitoneal immunization of mice with BSA. CT increased levels of anti-BSA specific IgG1, IgM, and IgA antibodies in the peritoneum and serum, as well as IgA and IgG1 antibodies in the intestinal fluids. The B subunit of CT (CTB) was as potent as CT itself, with potency comparable to that of incomplete Freund
Keywords Cytokine; Inflammation; NF-kB; Nitric Oxide; Reactive Oxygen Species
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Research Article
Mol. Cells 2003; 16(1): 106-112
Published online August 31, 2003
Copyright © The Korean Society for Molecular and Cellular Biology.
Intraperitoneal Delivery of Cholera Toxin B Subunit Enhances Systemic and Mucosal Antibody Responses
Su-Jung Park, Sung-Ki Chun, Pyeung-Hyeun Kim
Abstract
Although cholera toxin (CT) is a potent mucosal adjuvant, its activity in systemic immunity is relatively undocumented. In the present study, we investigated its adjuvant effect on systemic and mucosal antibody responses following intraperitoneal immunization of mice with BSA. CT increased levels of anti-BSA specific IgG1, IgM, and IgA antibodies in the peritoneum and serum, as well as IgA and IgG1 antibodies in the intestinal fluids. The B subunit of CT (CTB) was as potent as CT itself, with potency comparable to that of incomplete Freund
Keywords: Cytokine, Inflammation, NF-kB, Nitric Oxide, Reactive Oxygen Species
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