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Mol. Cells 2003; 16(3): 278-284

Published online January 1, 1970

© The Korean Society for Molecular and Cellular Biology

Age-related Changes in the Activity of Antioxidant and Redox Enzymes in Rats

Hong-Gyum Kim, Sung-Min Hong, Su-Jung Kim, Hey-Jung Park, Haeng-Im Jung, Yuk-Young Lee, Jeong-Su Moon, Hye-Won Lim, Eun-Hee Park, Chang-Jin Lim

Abstract

Cellular defense system, including glutathione, glu-tathione-related enzymes, and antioxidant and redox enzymes, may play crucial roles in the aging of aerobic organisms. To understand the physiological roles of these factors in the aging process, their levels were compared in the livers and brains of 5-week- and 9-month-old rats. GST activity was higher in livers and brains of 9-month-old rats than in those of 5-week-old rats, and brain catalase activity was about 2-fold higher. However, it was unchanged in the livers of the 9-month-old rats.

Keywords Aging; Antioxidant; Brain; Cellular Defense System; Liver; Rat; Redox Enzyme.

Article

Research Article

Mol. Cells 2003; 16(3): 278-284

Published online December 31, 2003

Copyright © The Korean Society for Molecular and Cellular Biology.

Age-related Changes in the Activity of Antioxidant and Redox Enzymes in Rats

Hong-Gyum Kim, Sung-Min Hong, Su-Jung Kim, Hey-Jung Park, Haeng-Im Jung, Yuk-Young Lee, Jeong-Su Moon, Hye-Won Lim, Eun-Hee Park, Chang-Jin Lim

Abstract

Cellular defense system, including glutathione, glu-tathione-related enzymes, and antioxidant and redox enzymes, may play crucial roles in the aging of aerobic organisms. To understand the physiological roles of these factors in the aging process, their levels were compared in the livers and brains of 5-week- and 9-month-old rats. GST activity was higher in livers and brains of 9-month-old rats than in those of 5-week-old rats, and brain catalase activity was about 2-fold higher. However, it was unchanged in the livers of the 9-month-old rats.

Keywords: Aging, Antioxidant, Brain, Cellular Defense System, Liver, Rat, Redox Enzyme.

Mol. Cells
Jun 30, 2023 Vol.46 No.6, pp. 329~398
COVER PICTURE
The cellular proteostasis network is adaptively modulated upon cellular stress, thereby protecting cells from proteostasis collapse. Heat shock induces the translocation of misfolded proteins and the chaperone protein HSP70 into nucleolus, where nuclear protein quality control primarily occurs. Nuclear RNA export factor 1 (green), nucleolar protein fibrillarin (red), and nuclei (blue) were visualized in NIH3T3 cells under basal (left) and heat shock (right) conditions (Park et al., pp. 374-386).

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