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Mol. Cells 2003; 16(3): 271-277
Published online January 1, 1970
© The Korean Society for Molecular and Cellular Biology
Molecular Mechanism for Activation of Superoxide-producing NADPH Oxidases
The membrane-integrated protein gp91phox, existing as a heterodimer with p22phox, functions as the catalytic core of the phagocyte NADPH oxidase, which plays a crucial role in host defence. The oxidase, dormant in resting cells, becomes activated to produce superoxide, a precursor of microbicidal oxidants, by interacting with the adaptor proteins p47phox and p67phox as well as the small GTPase Rac. In the past few years, several proteins homologous to gp91phox were discovered as superoxide-producing NAD(P)H oxidases (Nox
Keywords gp91phox; NADPH Oxidase; Nox1; Noxa1; Noxo1; ROS; Superoxide.
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Mol. Cells 2003; 16(3): 271-277
Published online December 31, 2003
Copyright © The Korean Society for Molecular and Cellular Biology.
Molecular Mechanism for Activation of Superoxide-producing NADPH Oxidases
Ryu Takeya, Hideki Sumimoto
Abstract
The membrane-integrated protein gp91phox, existing as a heterodimer with p22phox, functions as the catalytic core of the phagocyte NADPH oxidase, which plays a crucial role in host defence. The oxidase, dormant in resting cells, becomes activated to produce superoxide, a precursor of microbicidal oxidants, by interacting with the adaptor proteins p47phox and p67phox as well as the small GTPase Rac. In the past few years, several proteins homologous to gp91phox were discovered as superoxide-producing NAD(P)H oxidases (Nox
Keywords: gp91phox, NADPH Oxidase, Nox1, Noxa1, Noxo1, ROS, Superoxide.
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