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Mol. Cells 2003; 16(3): 271-277

Published online January 1, 1970

© The Korean Society for Molecular and Cellular Biology

Molecular Mechanism for Activation of Superoxide-producing NADPH Oxidases

Ryu Takeya, Hideki Sumimoto

Abstract

The membrane-integrated protein gp91phox, existing as a heterodimer with p22phox, functions as the catalytic core of the phagocyte NADPH oxidase, which plays a crucial role in host defence. The oxidase, dormant in resting cells, becomes activated to produce superoxide, a precursor of microbicidal oxidants, by interacting with the adaptor proteins p47phox and p67phox as well as the small GTPase Rac. In the past few years, several proteins homologous to gp91phox were discovered as superoxide-producing NAD(P)H oxidases (Nox

Keywords gp91phox; NADPH Oxidase; Nox1; Noxa1; Noxo1; ROS; Superoxide.

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Minireview

Mol. Cells 2003; 16(3): 271-277

Published online December 31, 2003

Copyright © The Korean Society for Molecular and Cellular Biology.

Molecular Mechanism for Activation of Superoxide-producing NADPH Oxidases

Ryu Takeya, Hideki Sumimoto

Abstract

The membrane-integrated protein gp91phox, existing as a heterodimer with p22phox, functions as the catalytic core of the phagocyte NADPH oxidase, which plays a crucial role in host defence. The oxidase, dormant in resting cells, becomes activated to produce superoxide, a precursor of microbicidal oxidants, by interacting with the adaptor proteins p47phox and p67phox as well as the small GTPase Rac. In the past few years, several proteins homologous to gp91phox were discovered as superoxide-producing NAD(P)H oxidases (Nox

Keywords: gp91phox, NADPH Oxidase, Nox1, Noxa1, Noxo1, ROS, Superoxide.

Mol. Cells
Mar 31, 2023 Vol.46 No.3, pp. 131~189
COVER PICTURE
The physiologically important cytoprotective signaling in normal cells (background area in turquoise) mediated by NRF2 (blue chain) is often hijacked by cancer cells (red ball) in the tumor microenvironment (yellow area). However, the differential roles of NRF2 throughout the multistage carcinogenesis remains largely unresolved (white-colored overlapping misty areas).

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