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Mol. Cells 2003; 16(3): 271-277

Published online December 31, 2003

© The Korean Society for Molecular and Cellular Biology

Molecular Mechanism for Activation of Superoxide-producing NADPH Oxidases

Ryu Takeya, Hideki Sumimoto

Abstract

The membrane-integrated protein gp91phox, existing as a heterodimer with p22phox, functions as the catalytic core of the phagocyte NADPH oxidase, which plays a crucial role in host defence. The oxidase, dormant in resting cells, becomes activated to produce superoxide, a precursor of microbicidal oxidants, by interacting with the adaptor proteins p47phox and p67phox as well as the small GTPase Rac. In the past few years, several proteins homologous to gp91phox were discovered as superoxide-producing NAD(P)H oxidases (Nox

Keywords gp91phox; NADPH Oxidase; Nox1; Noxa1; Noxo1; ROS; Superoxide.

Article

Minireview

Mol. Cells 2003; 16(3): 271-277

Published online December 31, 2003

Copyright © The Korean Society for Molecular and Cellular Biology.

Molecular Mechanism for Activation of Superoxide-producing NADPH Oxidases

Ryu Takeya, Hideki Sumimoto

Abstract

The membrane-integrated protein gp91phox, existing as a heterodimer with p22phox, functions as the catalytic core of the phagocyte NADPH oxidase, which plays a crucial role in host defence. The oxidase, dormant in resting cells, becomes activated to produce superoxide, a precursor of microbicidal oxidants, by interacting with the adaptor proteins p47phox and p67phox as well as the small GTPase Rac. In the past few years, several proteins homologous to gp91phox were discovered as superoxide-producing NAD(P)H oxidases (Nox

Keywords: gp91phox, NADPH Oxidase, Nox1, Noxa1, Noxo1, ROS, Superoxide.

Mol. Cells
Aug 31, 2022 Vol.45 No.8, pp. 513~602
COVER PICTURE
Cryo-EM structure of human porphyrin transporter ABCB6 (main figure) shows that binding of hemin (inset, magenta) in concert with two glutathione molecules (cyan) primes ABCB6 for high ATP turnover (Kim et al., pp. 575-587).

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