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Mol. Cells 2008; 26(5): 459-461

Published online January 1, 1970

© The Korean Society for Molecular and Cellular Biology

Novel Promoter Polymorphism in RUNX2 Is Associated with Serum Triglyceride Level

Hyoung Doo Shin, Jae-Pil Jeon, Byung Lae Park, Joon Seol Bae, Hye-Young Nam, Sung-Mi Shim, Kyong Soo Park and Bok-Ghee Han

Abstract

Much research evidence supports the hypothesis that chronic, low-grade inflammation related to innate immunity may play an important role in the pathophysiology of type 2 diabetes mellitus (T2DM). Runt-related transcription factor 2 (RUNX2; MIM# 600211) acts as a scaffold that controls the integration, organization, and assembly of nucleic acids. To examine whether the novel promoter variant in RUNX2 is associated with the risk of T2DM and related phenotypes, RUNX2-742G > T was genotyped in 378 T2DM patients and 382 normal controls recruited in the Korean T2DM Study. Statistical analysis revealed that RUNX2-742G > T was associated with serum triglyceride level (TG) in nondiabetic controls, although it was not associated with the risk of T2DM. Individuals who carry T/T, T/G, and G/G genotypes had the highest (2.061 ? 0.20), intermediate (2.01 ? 0.19), and the lowest (1.97 ? 0.18) levels of log [TG (mmol/l)] (P = 0.007), respectively. Our data on this important variant of RUNX2 suggest that lipid metabolism might be affected by genetic polymorphisms in the promoter region.

Keywords type 2 diabetes mellitus, RUNX2, polymorphism, promoter, triglyceride

Article

Research Article

Mol. Cells 2008; 26(5): 459-461

Published online November 30, 2008

Copyright © The Korean Society for Molecular and Cellular Biology.

Novel Promoter Polymorphism in RUNX2 Is Associated with Serum Triglyceride Level

Hyoung Doo Shin, Jae-Pil Jeon, Byung Lae Park, Joon Seol Bae, Hye-Young Nam, Sung-Mi Shim, Kyong Soo Park and Bok-Ghee Han

Abstract

Much research evidence supports the hypothesis that chronic, low-grade inflammation related to innate immunity may play an important role in the pathophysiology of type 2 diabetes mellitus (T2DM). Runt-related transcription factor 2 (RUNX2; MIM# 600211) acts as a scaffold that controls the integration, organization, and assembly of nucleic acids. To examine whether the novel promoter variant in RUNX2 is associated with the risk of T2DM and related phenotypes, RUNX2-742G > T was genotyped in 378 T2DM patients and 382 normal controls recruited in the Korean T2DM Study. Statistical analysis revealed that RUNX2-742G > T was associated with serum triglyceride level (TG) in nondiabetic controls, although it was not associated with the risk of T2DM. Individuals who carry T/T, T/G, and G/G genotypes had the highest (2.061 ? 0.20), intermediate (2.01 ? 0.19), and the lowest (1.97 ? 0.18) levels of log [TG (mmol/l)] (P = 0.007), respectively. Our data on this important variant of RUNX2 suggest that lipid metabolism might be affected by genetic polymorphisms in the promoter region.

Keywords: type 2 diabetes mellitus, RUNX2, polymorphism, promoter, triglyceride

Mol. Cells
Jan 31, 2023 Vol.46 No.1, pp. 1~67
COVER PICTURE
RNAs form diverse shapes and play multiple functions as central molecules of gene expression. In this special issue on RNA, seven minireviews illustrate how basic concepts and recent RNA biology findings are transformed into new and exciting RNA therapeutics.

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