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Mol. Cells 2006; 22(2): 228-232

Published online January 1, 1970

© The Korean Society for Molecular and Cellular Biology

Ovarian Tumors in Rbp9 Mutants of Drosophila Induce an Immune Response

Jihyun Kim, Chun Kim, Jeongsil Kim-Ha

Abstract

The Drosophila protein, Rbp9, is homologous to human Hu, which is reported to be involved in small cell lung cancer. Rbp9 functions in cystocyte differentiation, and mutations in Rbp9 cause ovarian tumors. Here we show that the antimicrobial peptide, Attacin, is upregulated in Rbp9 mutants, especially in ovaries where tumors form. Upregulation seems to result from activation of the NF-κB pathway since we detected nuclear localization of Relish in Rbp9 mutant ovaries but not in wild type ovaries. Inactivation of NF-κB in the Rbp9 mutant allows prolonged survival of malformed egg chambers. We conclude that Drosophila initiates an anti-tumor defense response via activation of NF-κB.

Keywords Antimicrobial Peptides; NF-κB; Ovarian Tumor; Rbp9.

Article

Research Article

Mol. Cells 2006; 22(2): 228-232

Published online October 31, 2006

Copyright © The Korean Society for Molecular and Cellular Biology.

Ovarian Tumors in Rbp9 Mutants of Drosophila Induce an Immune Response

Jihyun Kim, Chun Kim, Jeongsil Kim-Ha

Abstract

The Drosophila protein, Rbp9, is homologous to human Hu, which is reported to be involved in small cell lung cancer. Rbp9 functions in cystocyte differentiation, and mutations in Rbp9 cause ovarian tumors. Here we show that the antimicrobial peptide, Attacin, is upregulated in Rbp9 mutants, especially in ovaries where tumors form. Upregulation seems to result from activation of the NF-κB pathway since we detected nuclear localization of Relish in Rbp9 mutant ovaries but not in wild type ovaries. Inactivation of NF-κB in the Rbp9 mutant allows prolonged survival of malformed egg chambers. We conclude that Drosophila initiates an anti-tumor defense response via activation of NF-κB.

Keywords: Antimicrobial Peptides, NF-κB, Ovarian Tumor, Rbp9.

Mol. Cells
Jan 31, 2023 Vol.46 No.1, pp. 1~67
COVER PICTURE
RNAs form diverse shapes and play multiple functions as central molecules of gene expression. In this special issue on RNA, seven minireviews illustrate how basic concepts and recent RNA biology findings are transformed into new and exciting RNA therapeutics.

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