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Mol. Cells 2007; 23(2): 215-219

Published online January 1, 1970

© The Korean Society for Molecular and Cellular Biology

TTF-1 Expression in PACAP-expressing Retinal Ganglion Cells

Young June Son, Jeong Woo Park, Byung Ju Lee

Abstract

In mammals light input resets the central clock of the suprachiasmatic nucleus by inducing secretion of pituitary adenylate cyclase-activating polypeptide (PACAP) from retinal ganglion cells (RGCs). We previously showed that thyroid transcription factor 1 (TTF-1), a homeodomain-containing transcription factor, specifically regulates PACAP gene expression in the rat hypothalamus. In the present study we examined the expression of TTF-1 in PACAP-synthesizing retinal cells. Fluorescence in situ hybridization (FISH) showed that it is abundantly expressed in RGCs of the superior region of the retina, but in only a small subset of RGCs in the inferior region. Double FISH experiments revealed that TTF-1 is exclusively expressed in PACAP-producing RGCs. These results suggest that TTF-1 plays a regulatory role in PACAP-expressing retinal ganglion cells.

Keywords Hormones; Incompatible Interactions; Rice Blast Fungus., Expression Pattern; Melanopsin; Retinal Ganglion Cells;, Thyroid Transcription Factor 1 (TTF-1)

Article

Research Article

Mol. Cells 2007; 23(2): 215-219

Published online April 30, 2007

Copyright © The Korean Society for Molecular and Cellular Biology.

TTF-1 Expression in PACAP-expressing Retinal Ganglion Cells

Young June Son, Jeong Woo Park, Byung Ju Lee

Abstract

In mammals light input resets the central clock of the suprachiasmatic nucleus by inducing secretion of pituitary adenylate cyclase-activating polypeptide (PACAP) from retinal ganglion cells (RGCs). We previously showed that thyroid transcription factor 1 (TTF-1), a homeodomain-containing transcription factor, specifically regulates PACAP gene expression in the rat hypothalamus. In the present study we examined the expression of TTF-1 in PACAP-synthesizing retinal cells. Fluorescence in situ hybridization (FISH) showed that it is abundantly expressed in RGCs of the superior region of the retina, but in only a small subset of RGCs in the inferior region. Double FISH experiments revealed that TTF-1 is exclusively expressed in PACAP-producing RGCs. These results suggest that TTF-1 plays a regulatory role in PACAP-expressing retinal ganglion cells.

Keywords: Hormones, Incompatible Interactions, Rice Blast Fungus., Expression Pattern, Melanopsin, Retinal Ganglion Cells,, Thyroid Transcription Factor 1 (TTF-1)

Mol. Cells
May 31, 2023 Vol.46 No.5, pp. 259~328
COVER PICTURE
The alpha-helices in the lamin filaments are depicted as coils, with different subdomains distinguished by various colors. Coil 1a is represented by magenta, coil 1b by yellow, L2 by green, coil 2a by white, coil 2b by brown, stutter by cyan, coil 2c by dark blue, and the lamin Ig-like domain by grey. In the background, cells are displayed, with the cytosol depicted in green and the nucleus in blue (Ahn et al., pp. 309-318).

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