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Mol. Cells 2007; 23(2): 123-131

Published online January 1, 1970

© The Korean Society for Molecular and Cellular Biology

Heat Shock Responses for Understanding Diseases of Protein Denaturation

Hee-Jung Kim, Na Rae Hwang, Kong-Joo Lee

Abstract

Extracellular stresses induce heat shock response and render cells resistant to lethal stresses. Heat shock response involves induction of heat shock proteins (Hsps). Recently the roles of Hsps in neurodegenerative diseases and cancer are attracting increasing attention and have accelerated the study of heat shock response mechanism. This review focuses on the stress sensing steps, molecules involved in Hsps production, diseases related to Hsp malfunctions, and the potential of proteomics as a tool for understanding the complex signaling pathways relevant to these events.

Keywords Heat Shock Factor; Heat Shock Protein;, Heat Shock Response; MAPK; Misfolding of Protein; ROS;, Ubiquitin-Proteasome System

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Mol. Cells 2007; 23(2): 123-131

Published online April 30, 2007

Copyright © The Korean Society for Molecular and Cellular Biology.

Heat Shock Responses for Understanding Diseases of Protein Denaturation

Hee-Jung Kim, Na Rae Hwang, Kong-Joo Lee

Abstract

Extracellular stresses induce heat shock response and render cells resistant to lethal stresses. Heat shock response involves induction of heat shock proteins (Hsps). Recently the roles of Hsps in neurodegenerative diseases and cancer are attracting increasing attention and have accelerated the study of heat shock response mechanism. This review focuses on the stress sensing steps, molecules involved in Hsps production, diseases related to Hsp malfunctions, and the potential of proteomics as a tool for understanding the complex signaling pathways relevant to these events.

Keywords: Heat Shock Factor, Heat Shock Protein,, Heat Shock Response, MAPK, Misfolding of Protein, ROS,, Ubiquitin-Proteasome System

Mol. Cells
Nov 30, 2023 Vol.46 No.11, pp. 655~725
COVER PICTURE
Kim et al. (pp. 710-724) demonstrated that a pathogen-derived Ralstonia pseudosolanacearum type III effector RipL delays flowering time and enhances susceptibility to bacterial infection in Arabidopsis thaliana. Shown is the RipL-expressing Arabidopsis plant, which displays general dampening of the transcriptional program during pathogen infection, grown in long-day conditions.

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Molecules and Cells

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