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Mol. Cells 2007; 23(2): 123-131

Published online January 1, 1970

© The Korean Society for Molecular and Cellular Biology

Heat Shock Responses for Understanding Diseases of Protein Denaturation

Hee-Jung Kim, Na Rae Hwang, Kong-Joo Lee

Abstract

Extracellular stresses induce heat shock response and render cells resistant to lethal stresses. Heat shock response involves induction of heat shock proteins (Hsps). Recently the roles of Hsps in neurodegenerative diseases and cancer are attracting increasing attention and have accelerated the study of heat shock response mechanism. This review focuses on the stress sensing steps, molecules involved in Hsps production, diseases related to Hsp malfunctions, and the potential of proteomics as a tool for understanding the complex signaling pathways relevant to these events.

Keywords Heat Shock Factor; Heat Shock Protein;, Heat Shock Response; MAPK; Misfolding of Protein; ROS;, Ubiquitin-Proteasome System

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Minireview

Mol. Cells 2007; 23(2): 123-131

Published online April 30, 2007

Copyright © The Korean Society for Molecular and Cellular Biology.

Heat Shock Responses for Understanding Diseases of Protein Denaturation

Hee-Jung Kim, Na Rae Hwang, Kong-Joo Lee

Abstract

Extracellular stresses induce heat shock response and render cells resistant to lethal stresses. Heat shock response involves induction of heat shock proteins (Hsps). Recently the roles of Hsps in neurodegenerative diseases and cancer are attracting increasing attention and have accelerated the study of heat shock response mechanism. This review focuses on the stress sensing steps, molecules involved in Hsps production, diseases related to Hsp malfunctions, and the potential of proteomics as a tool for understanding the complex signaling pathways relevant to these events.

Keywords: Heat Shock Factor, Heat Shock Protein,, Heat Shock Response, MAPK, Misfolding of Protein, ROS,, Ubiquitin-Proteasome System

Mol. Cells
Feb 28, 2023 Vol.46 No.2, pp. 69~129
COVER PICTURE
The bulk tissue is a heterogeneous mixture of various cell types, which is depicted as a skein of intertwined threads with diverse colors each of which represents a unique cell type. Single-cell omics analysis untangles efficiently the skein according to the color by providing information of molecules at individual cells and interpretation of such information based on different cell types. The molecules that can be profiled at the individual cell by single-cell omics analysis includes DNA (bottom middle), RNA (bottom right), and protein (bottom left). This special issue reviews single-cell technologies and computational methods that have been developed for the single-cell omics analysis and how they have been applied to improve our understanding of the underlying mechanisms of biological and pathological phenomena at the single-cell level.

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Molecules and Cells

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