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Mol. Cells 2007; 23(2): 123-131

Published online April 30, 2007

© The Korean Society for Molecular and Cellular Biology

Heat Shock Responses for Understanding Diseases of Protein Denaturation

Hee-Jung Kim, Na Rae Hwang, Kong-Joo Lee

Abstract

Extracellular stresses induce heat shock response and render cells resistant to lethal stresses. Heat shock response involves induction of heat shock proteins (Hsps). Recently the roles of Hsps in neurodegenerative diseases and cancer are attracting increasing attention and have accelerated the study of heat shock response mechanism. This review focuses on the stress sensing steps, molecules involved in Hsps production, diseases related to Hsp malfunctions, and the potential of proteomics as a tool for understanding the complex signaling pathways relevant to these events.

Keywords Heat Shock Factor; Heat Shock Protein;, Heat Shock Response; MAPK; Misfolding of Protein; ROS;, Ubiquitin-Proteasome System

Article

Minireview

Mol. Cells 2007; 23(2): 123-131

Published online April 30, 2007

Copyright © The Korean Society for Molecular and Cellular Biology.

Heat Shock Responses for Understanding Diseases of Protein Denaturation

Hee-Jung Kim, Na Rae Hwang, Kong-Joo Lee

Abstract

Extracellular stresses induce heat shock response and render cells resistant to lethal stresses. Heat shock response involves induction of heat shock proteins (Hsps). Recently the roles of Hsps in neurodegenerative diseases and cancer are attracting increasing attention and have accelerated the study of heat shock response mechanism. This review focuses on the stress sensing steps, molecules involved in Hsps production, diseases related to Hsp malfunctions, and the potential of proteomics as a tool for understanding the complex signaling pathways relevant to these events.

Keywords: Heat Shock Factor, Heat Shock Protein,, Heat Shock Response, MAPK, Misfolding of Protein, ROS,, Ubiquitin-Proteasome System

Mol. Cells
Nov 30, 2022 Vol.45 No.11, pp. 763~867
COVER PICTURE
Naive (cyan) and axotomized (magenta) retinal ganglion cell axons in Xenopus tropicalis (Choi et al., pp. 846-854).

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