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Mol. Cells 2013; 36(5): 385-392

Published online November 30, 2013

https://doi.org/10.1007/s10059-013-0297-1

© The Korean Society for Molecular and Cellular Biology

Regulation of SIRT1 by MicroRNAs

Sung-E Choi, and Jongsook Kim Kemper

1Department of Molecular and Integrative Physiology, University of Illinois at Urbana, IL 61801, USA, 2Chronic Inflammatory Disease Research Center, Ajou University, Suwon 442-749, Korea

Received: September 30, 2013; Accepted: October 3, 2013

Abstract

Sirtuin 1 (SIRT1) is an NAD+-dependent deacetylase that connects cellular energy levels to homeostatic responses by deacetylating and modulating the activities of many transcriptional regulators. Discovered as a longevity protein in yeast, the mammalian SIRT1 has been intensively studied because of its great potential as a therapeutic target to benefit human health by preventing and improving many age-related diseases. There has been, therefore, substantial interest in developing agents that upregulate SIRT1 expression and activity. SIRT1 is regulated at multiple levels, including post-transcriptionally by microRNAs (miRs), powerful regulators of diverse biological pathways. Here we discuss how expression and activity of SIRT1 and other sirtuins are inhibited by miRs and further discuss the therapeutic potential of targeting miRs for age-related diseases that involve SIRT1 dysfunction, focusing on obesityrelated diseases.

Keywords aging, deacetylase, NAD, NAMPT, obesity, therapeutics

Article

Minireview

Mol. Cells 2013; 36(5): 385-392

Published online November 30, 2013 https://doi.org/10.1007/s10059-013-0297-1

Copyright © The Korean Society for Molecular and Cellular Biology.

Regulation of SIRT1 by MicroRNAs

Sung-E Choi, and Jongsook Kim Kemper

1Department of Molecular and Integrative Physiology, University of Illinois at Urbana, IL 61801, USA, 2Chronic Inflammatory Disease Research Center, Ajou University, Suwon 442-749, Korea

Received: September 30, 2013; Accepted: October 3, 2013

Abstract

Sirtuin 1 (SIRT1) is an NAD+-dependent deacetylase that connects cellular energy levels to homeostatic responses by deacetylating and modulating the activities of many transcriptional regulators. Discovered as a longevity protein in yeast, the mammalian SIRT1 has been intensively studied because of its great potential as a therapeutic target to benefit human health by preventing and improving many age-related diseases. There has been, therefore, substantial interest in developing agents that upregulate SIRT1 expression and activity. SIRT1 is regulated at multiple levels, including post-transcriptionally by microRNAs (miRs), powerful regulators of diverse biological pathways. Here we discuss how expression and activity of SIRT1 and other sirtuins are inhibited by miRs and further discuss the therapeutic potential of targeting miRs for age-related diseases that involve SIRT1 dysfunction, focusing on obesityrelated diseases.

Keywords: aging, deacetylase, NAD, NAMPT, obesity, therapeutics

Mol. Cells
Nov 30, 2022 Vol.45 No.11, pp. 763~867
COVER PICTURE
Naive (cyan) and axotomized (magenta) retinal ganglion cell axons in Xenopus tropicalis (Choi et al., pp. 846-854).

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