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Mol. Cells 2013; 36(4): 288-303

Published online October 31, 2013

https://doi.org/10.1007/s10059-013-0246-z

© The Korean Society for Molecular and Cellular Biology

Primary Cilia and Dendritic Spines: Different but Similar Signaling Compartments

Inna V. Nechipurenko, David B. Doroquez, and Piali Sengupta

Department of Biology and National Center for Behavioral Genomics, Brandeis University, Waltham, MA 02454, USA

Received: August 30, 2013; Accepted: September 2, 2013

Abstract

Primary non-motile cilia and dendritic spines are cellular compartments that are specialized to sense and transduce environmental cues and presynaptic signals, respectively. Despite their unique cellular roles, both compartments exhibit remarkable parallels in the general principles, as well as molecular mechanisms, by which their protein composition, membrane domain architecture, cellular interactions, and structural and functional plasticity are regulated. We compare and contrast the pathways required for the generation and function of cilia and dendritic spines, and suggest that insights from the study of one may inform investigations into the other of these critically important signaling structures.

Keywords dendritic spines, diffusion barrier, primary cilia, protein trafficking, structural plasticity

Article

Minireview

Mol. Cells 2013; 36(4): 288-303

Published online October 31, 2013 https://doi.org/10.1007/s10059-013-0246-z

Copyright © The Korean Society for Molecular and Cellular Biology.

Primary Cilia and Dendritic Spines: Different but Similar Signaling Compartments

Inna V. Nechipurenko, David B. Doroquez, and Piali Sengupta

Department of Biology and National Center for Behavioral Genomics, Brandeis University, Waltham, MA 02454, USA

Received: August 30, 2013; Accepted: September 2, 2013

Abstract

Primary non-motile cilia and dendritic spines are cellular compartments that are specialized to sense and transduce environmental cues and presynaptic signals, respectively. Despite their unique cellular roles, both compartments exhibit remarkable parallels in the general principles, as well as molecular mechanisms, by which their protein composition, membrane domain architecture, cellular interactions, and structural and functional plasticity are regulated. We compare and contrast the pathways required for the generation and function of cilia and dendritic spines, and suggest that insights from the study of one may inform investigations into the other of these critically important signaling structures.

Keywords: dendritic spines, diffusion barrier, primary cilia, protein trafficking, structural plasticity

Mol. Cells
Jul 31, 2022 Vol.45 No.7, pp. 435~512
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