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Mol. Cells 2013; 35(5): 359-370

Published online May 31, 2013

https://doi.org/10.1007/s10059-013-0127-5

© The Korean Society for Molecular and Cellular Biology

Emerging Tools for Synthetic Genome Design

Bo-Rahm Lee, Suhyung Cho, Yoseb Song, Sun Chang Kim, and Byung-Kwan Cho

1Intelligent Synthetic Biology Center, Daejeon 305-701, Korea, 2Department of Biological Sciences and Korea Advanced Institute of Science and Technology Institute for the BioCentury, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea

Received: April 23, 2013; Accepted: April 26, 2013

Abstract

Synthetic biology is an emerging discipline for designing and synthesizing predictable, measurable, controllable, and transformable biological systems. These newly de-signed biological systems have great potential for the development of cheaper drugs, green fuels, biodegradable plastics, and targeted cancer therapies over the coming years. Fortunately, our ability to quickly and accurately engineer biological systems that behave predictably has been dramatically expanded by significant advances in DNA-sequencing, DNA-synthesis, and DNA-editing technologies. Here, we review emerging technologies and methodologies in the field of building designed biological systems, and we discuss their future perspectives.

Keywords genome, genome editing, next-generation sequencing, synthetic biology

Article

Minireview

Mol. Cells 2013; 35(5): 359-370

Published online May 31, 2013 https://doi.org/10.1007/s10059-013-0127-5

Copyright © The Korean Society for Molecular and Cellular Biology.

Emerging Tools for Synthetic Genome Design

Bo-Rahm Lee, Suhyung Cho, Yoseb Song, Sun Chang Kim, and Byung-Kwan Cho

1Intelligent Synthetic Biology Center, Daejeon 305-701, Korea, 2Department of Biological Sciences and Korea Advanced Institute of Science and Technology Institute for the BioCentury, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea

Received: April 23, 2013; Accepted: April 26, 2013

Abstract

Synthetic biology is an emerging discipline for designing and synthesizing predictable, measurable, controllable, and transformable biological systems. These newly de-signed biological systems have great potential for the development of cheaper drugs, green fuels, biodegradable plastics, and targeted cancer therapies over the coming years. Fortunately, our ability to quickly and accurately engineer biological systems that behave predictably has been dramatically expanded by significant advances in DNA-sequencing, DNA-synthesis, and DNA-editing technologies. Here, we review emerging technologies and methodologies in the field of building designed biological systems, and we discuss their future perspectives.

Keywords: genome, genome editing, next-generation sequencing, synthetic biology

Mol. Cells
Dec 31, 2021 Vol.44 No.12, pp. 861~919
COVER PICTURE
Structure of the fly peripheral neurons in the fly head. Flies have basic sensory organs including eyes for vision, antennae and maxillary palps for olfaction, and proboscis (magenta) for gustation which can be labelled with monoclonal antibody 22C10. The figure is a 3D reconstructed image with 30 slices of confocal sections with 3 μm interval. It shows that the proboscis is required for sensing attractive carboxylic acids such as glycolic acid, citric acid, and lactic acid (Shrestha and Lee, pp. 900-910).

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