Top

Minireview

Split Viewer

Mol. Cells 2013; 35(5): 359-370

Published online May 2, 2013

https://doi.org/10.1007/s10059-013-0127-5

© The Korean Society for Molecular and Cellular Biology

Emerging Tools for Synthetic Genome Design

Bo-Rahm Lee, Suhyung Cho, Yoseb Song, Sun Chang Kim, and Byung-Kwan Cho

1Intelligent Synthetic Biology Center, Daejeon 305-701, Korea, 2Department of Biological Sciences and Korea Advanced Institute of Science and Technology Institute for the BioCentury, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea

Received: April 23, 2013; Accepted: April 26, 2013

Abstract

Synthetic biology is an emerging discipline for designing and synthesizing predictable, measurable, controllable, and transformable biological systems. These newly de-signed biological systems have great potential for the development of cheaper drugs, green fuels, biodegradable plastics, and targeted cancer therapies over the coming years. Fortunately, our ability to quickly and accurately engineer biological systems that behave predictably has been dramatically expanded by significant advances in DNA-sequencing, DNA-synthesis, and DNA-editing technologies. Here, we review emerging technologies and methodologies in the field of building designed biological systems, and we discuss their future perspectives.

Keywords genome, genome editing, next-generation sequencing, synthetic biology

Article

Minireview

Mol. Cells 2013; 35(5): 359-370

Published online May 31, 2013 https://doi.org/10.1007/s10059-013-0127-5

Copyright © The Korean Society for Molecular and Cellular Biology.

Emerging Tools for Synthetic Genome Design

Bo-Rahm Lee, Suhyung Cho, Yoseb Song, Sun Chang Kim, and Byung-Kwan Cho

1Intelligent Synthetic Biology Center, Daejeon 305-701, Korea, 2Department of Biological Sciences and Korea Advanced Institute of Science and Technology Institute for the BioCentury, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea

Received: April 23, 2013; Accepted: April 26, 2013

Abstract

Synthetic biology is an emerging discipline for designing and synthesizing predictable, measurable, controllable, and transformable biological systems. These newly de-signed biological systems have great potential for the development of cheaper drugs, green fuels, biodegradable plastics, and targeted cancer therapies over the coming years. Fortunately, our ability to quickly and accurately engineer biological systems that behave predictably has been dramatically expanded by significant advances in DNA-sequencing, DNA-synthesis, and DNA-editing technologies. Here, we review emerging technologies and methodologies in the field of building designed biological systems, and we discuss their future perspectives.

Keywords: genome, genome editing, next-generation sequencing, synthetic biology

Mol. Cells
Jan 31, 2023 Vol.46 No.1, pp. 1~67
COVER PICTURE
RNAs form diverse shapes and play multiple functions as central molecules of gene expression. In this special issue on RNA, seven minireviews illustrate how basic concepts and recent RNA biology findings are transformed into new and exciting RNA therapeutics.

Share this article on

  • line
  • mail

Related articles in Mol. Cells

Molecules and Cells

eISSN 0219-1032
qr-code Download