Mol. Cells 2013; 35(1): 17-24
Published online December 3, 2012
https://doi.org/10.1007/s10059-013-2154-7
© The Korean Society for Molecular and Cellular Biology
MicroRNA (miRNA) is a form of small noncoding RNA that regulates the expression of genes either by inhibiting
mRNA translation or by inducing its degradation. Small microRNA play important roles in regulating a large number
of cellular processes, including development, proliferation and apoptosis. This study examined the biological
functions of miR-205 as a tumor suppressor in KB oral cancer cells. The results showed that miR-205 expression
was significantly lower in KB oral cancer cells than in human normal oral keratinocytes. Furthermore, the miR-205
over-expressed in KB oral cancer cells increased the cell cytotoxicity and induced apoptosis through the activation
of caspase-3/-7. The transfection of miR-205 into KB oral cancer cells strongly induced IL-24, a well known cytokine
that acts as a tumor suppressor in a range of tumor tissues. In addition, miR-205 targeted the IL-24 promoter directly
to induce gene expression. Overall, miR-205 has significant therapeutic potential to turn on silenced tumor
suppressor genes by targeting them with miRNA.
Keywords apoptosis, human oral cancer, interleukin-24, microRNA-205
Mol. Cells 2013; 35(1): 17-24
Published online January 31, 2013 https://doi.org/10.1007/s10059-013-2154-7
Copyright © The Korean Society for Molecular and Cellular Biology.
Jae-Sung Kim, Sun-Kyoung Yu, Myoung-Hwa Lee, Min-Gyeong Park, Euteum Park, Su-Gwan Kim, Sook-Young Lee, Chun Sung Kim, Heung-Joong Kim, Hong Sung Chun, Sang-Woo Chun, and Do Kyung Kim
Oral Biology Research Institute, Chosun University School of Dentistry, Gwangju, Korea, Department of Biotechnology, Regional Innovation Center for Dental Science and Engineering, Chosun University, Gwangju, Korea, 4Department of Oral Physiology, College of Dentistry, Institute of Wonkwang Biomaterial and Implant, Wonkwang University, Iksan, Korea
MicroRNA (miRNA) is a form of small noncoding RNA that regulates the expression of genes either by inhibiting
mRNA translation or by inducing its degradation. Small microRNA play important roles in regulating a large number
of cellular processes, including development, proliferation and apoptosis. This study examined the biological
functions of miR-205 as a tumor suppressor in KB oral cancer cells. The results showed that miR-205 expression
was significantly lower in KB oral cancer cells than in human normal oral keratinocytes. Furthermore, the miR-205
over-expressed in KB oral cancer cells increased the cell cytotoxicity and induced apoptosis through the activation
of caspase-3/-7. The transfection of miR-205 into KB oral cancer cells strongly induced IL-24, a well known cytokine
that acts as a tumor suppressor in a range of tumor tissues. In addition, miR-205 targeted the IL-24 promoter directly
to induce gene expression. Overall, miR-205 has significant therapeutic potential to turn on silenced tumor
suppressor genes by targeting them with miRNA.
Keywords: apoptosis, human oral cancer, interleukin-24, microRNA-205
Soo-Jin Lee, Sung-E Choi, Seokho Park, Yoonjung Hwang, Youngho Son, and Yup Kang*
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