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Mol. Cells 2011; 32(6): 549-554

Published online December 31, 2011

https://doi.org/10.1007/s10059-011-0173-9

© The Korean Society for Molecular and Cellular Biology

The Pleiohomeotic Functions as a Negative Regulator of Drosophila even-skipped Gene during Embryogenesis

Su Na Kim1,5,6, Hyun Pyo Shim1,6, Bu-Nam Jeon2, Won-Il Choi2, Man-Wook Hur2, Jack R. Girton3, Sang Hee Kim4, and Sang-Hak Jeon1,*

1Department of Biology Education, Seoul National University, Seoul 151-748, Korea, 2Department of Biochemistry and Molecular Biology, Yonsei University School of Medicine, Seoul 120-752, Korea, 3Department of BBMB, Iowa State University, IA 50011, USA, 4Department of Chemistry, Konkuk University, Seoul 143-701, Korea, 5Present address: Institute of Neuro and Behavioral Biology, University of M?nster, M?nster, Germany, 6These authors contributed equally to this work.

Correspondence to : *Correspondence: jeonsh@snu.ac.kr

Received: August 20, 2011; Revised: September 28, 2011; Accepted: September 29, 2011

Abstract

Polycomb group (PcG) proteins maintain the spatial ex-pression patterns of genes that are involved in cell-fate specification along the anterior-posterior (A/P) axis. This repression requires cis-acting silencers, which are called PcG response elements (PREs). One of the PcG proteins, Pleiohomeotic (Pho), which has a zinc finger DNA binding protein, plays a critical role in recruiting other PcG proteins to bind to PREs. In this study, we characterized the effects of a pho mutation on embryonic segmentation. pho maternal mutant embryos showed various segmental defects including pair-rule gene mutant patterns. Our results indicated that engrailed and even-skipped genes were misexpressed in pho mutant embryos, which caused embryonic segment defects.

Keywords eve, Drosophila melanogaster, GAGA, pleiohomeotic, Polycomb group genes, PRE, segmentation genes

Article

Research Article

Mol. Cells 2011; 32(6): 549-554

Published online December 31, 2011 https://doi.org/10.1007/s10059-011-0173-9

Copyright © The Korean Society for Molecular and Cellular Biology.

The Pleiohomeotic Functions as a Negative Regulator of Drosophila even-skipped Gene during Embryogenesis

Su Na Kim1,5,6, Hyun Pyo Shim1,6, Bu-Nam Jeon2, Won-Il Choi2, Man-Wook Hur2, Jack R. Girton3, Sang Hee Kim4, and Sang-Hak Jeon1,*

1Department of Biology Education, Seoul National University, Seoul 151-748, Korea, 2Department of Biochemistry and Molecular Biology, Yonsei University School of Medicine, Seoul 120-752, Korea, 3Department of BBMB, Iowa State University, IA 50011, USA, 4Department of Chemistry, Konkuk University, Seoul 143-701, Korea, 5Present address: Institute of Neuro and Behavioral Biology, University of M?nster, M?nster, Germany, 6These authors contributed equally to this work.

Correspondence to:*Correspondence: jeonsh@snu.ac.kr

Received: August 20, 2011; Revised: September 28, 2011; Accepted: September 29, 2011

Abstract

Polycomb group (PcG) proteins maintain the spatial ex-pression patterns of genes that are involved in cell-fate specification along the anterior-posterior (A/P) axis. This repression requires cis-acting silencers, which are called PcG response elements (PREs). One of the PcG proteins, Pleiohomeotic (Pho), which has a zinc finger DNA binding protein, plays a critical role in recruiting other PcG proteins to bind to PREs. In this study, we characterized the effects of a pho mutation on embryonic segmentation. pho maternal mutant embryos showed various segmental defects including pair-rule gene mutant patterns. Our results indicated that engrailed and even-skipped genes were misexpressed in pho mutant embryos, which caused embryonic segment defects.

Keywords: eve, Drosophila melanogaster, GAGA, pleiohomeotic, Polycomb group genes, PRE, segmentation genes

Mol. Cells
Jan 31, 2023 Vol.46 No.1, pp. 1~67
COVER PICTURE
RNAs form diverse shapes and play multiple functions as central molecules of gene expression. In this special issue on RNA, seven minireviews illustrate how basic concepts and recent RNA biology findings are transformed into new and exciting RNA therapeutics.

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