Suhyun Kim" /> Suhyun Kim, Ah-Young Chung, Dohyun Kim, Young-Seop Kim, Hyung-Seok Kim, Hyung-Wook Kwon, Tae-Lin Huh, and Hae-Chul Park*

" /> Suhyun Kim, Ah-Young Chung, Dohyun Kim, Young-Seop Kim, Hyung-Seok Kim, Hyung-Wook Kwon, Tae-Lin Huh, and Hae-Chul Park*

. Mol. Cells 2011;32:383-8. https://doi.org/10.1007/s10059-011-0152-1">
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Mol. Cells 2011; 32(4): 383-388

Published online October 31, 2011

https://doi.org/10.1007/s10059-011-0152-1

© The Korean Society for Molecular and Cellular Biology

Tcf3 Function Is Required for the Inhibition of Oligodendroglial Fate Specification in the Spinal Cord of Zebrafish Embryos

Suhyun Kim, Ah-Young Chung, Dohyun Kim, Young-Seop Kim1, Hyung-Seok Kim1, Hyung-Wook Kwon2, Tae-Lin Huh1, and Hae-Chul Park*

Graduate School of Medicine, Korea University, Ansan 425-707, Korea, 1Department of Genetic Engineering, Kyungpook National University, Daegu 702-701, Korea, 2World Class University Biomodulation Major, Department of Agricultural Biotechnology, Seoul National University, Seoul 151-742 , Korea

Correspondence to : *Correspondence: hcpark67@korea.ac.kr

Received: July 20, 2011; Revised: August 11, 2011; Accepted: August 12, 2011

Abstract

The generation of various subtypes of neurons and glial cells at the right time and place is crucial for the proper development of the vertebrate CNS. Although the mechanisms and factors for the regulation of neuronal diversity in the CNS have been well studied, the mechanisms regulating the sequential production of neuronal and glial cells from neural precursors remain poorly understood. This study shows that Tcf3, a member of the Lef/Tcf family of proteins, is required to inhibit the premature oligodendroglial fate specification of spinal cord precursors using the transgenic zebrafish, which expresses a dominant repressor form of Tcf3 under the control of a heat-shock inducible promoter. In addition, the data revealed that Tcf3 function in oligodendroglial fate specification is mediated in-dependently of canonical Wnt signaling. Altogether, these results show a novel function for Tcf3 in regulating the timing of oligodendroglial fate specification in the spinal cord.

Keywords neurogenesis, oligodendrocytes, spinal cord, Tcf3, zebrafish

Article

Research Article

Mol. Cells 2011; 32(4): 383-388

Published online October 31, 2011 https://doi.org/10.1007/s10059-011-0152-1

Copyright © The Korean Society for Molecular and Cellular Biology.

Tcf3 Function Is Required for the Inhibition of Oligodendroglial Fate Specification in the Spinal Cord of Zebrafish Embryos

Suhyun Kim, Ah-Young Chung, Dohyun Kim, Young-Seop Kim1, Hyung-Seok Kim1, Hyung-Wook Kwon2, Tae-Lin Huh1, and Hae-Chul Park*

Graduate School of Medicine, Korea University, Ansan 425-707, Korea, 1Department of Genetic Engineering, Kyungpook National University, Daegu 702-701, Korea, 2World Class University Biomodulation Major, Department of Agricultural Biotechnology, Seoul National University, Seoul 151-742 , Korea

Correspondence to:*Correspondence: hcpark67@korea.ac.kr

Received: July 20, 2011; Revised: August 11, 2011; Accepted: August 12, 2011

Abstract

The generation of various subtypes of neurons and glial cells at the right time and place is crucial for the proper development of the vertebrate CNS. Although the mechanisms and factors for the regulation of neuronal diversity in the CNS have been well studied, the mechanisms regulating the sequential production of neuronal and glial cells from neural precursors remain poorly understood. This study shows that Tcf3, a member of the Lef/Tcf family of proteins, is required to inhibit the premature oligodendroglial fate specification of spinal cord precursors using the transgenic zebrafish, which expresses a dominant repressor form of Tcf3 under the control of a heat-shock inducible promoter. In addition, the data revealed that Tcf3 function in oligodendroglial fate specification is mediated in-dependently of canonical Wnt signaling. Altogether, these results show a novel function for Tcf3 in regulating the timing of oligodendroglial fate specification in the spinal cord.

Keywords: neurogenesis, oligodendrocytes, spinal cord, Tcf3, zebrafish

Mol. Cells
Aug 31, 2022 Vol.45 No.8, pp. 513~602
COVER PICTURE
Cryo-EM structure of human porphyrin transporter ABCB6 (main figure) shows that binding of hemin (inset, magenta) in concert with two glutathione molecules (cyan) primes ABCB6 for high ATP turnover (Kim et al., pp. 575-587).

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