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Mol. Cells 2011; 32(4): 375-381

Published online August 24, 2011

https://doi.org/10.1007/s10059-011-0128-1

© The Korean Society for Molecular and Cellular Biology

A Systematic Analysis of Drosophila Gustatory Receptor Gene Expression in Abdominal Neurons which Project to the Central Nervous System

Jeong-Ho Park, and Jae Young Kwon*

Department of Biological Sciences, Sungkyunkwan University, Suwon 440-746, Korea

Correspondence to : *Corresponding author: jykwon@skku.edu

Received: June 20, 2011; Revised: July 11, 2011; Accepted: July 12, 2011

Abstract

In Drosophila, the gustatory receptor (Gr) gene family contains 60 family members that encode 68 proteins through alternative splicing. Some gustatory receptors (Grs) are involved in the sensing of sugars, bitter sub-strates, CO2, pheromones, and light. Here, we systemati-cally examined the expression of all 68 Grs in abdominal neurons which project to the abdominal ganglion of the central nervous system using the GAL4/UAS system. Gr gene expression patterns have been successfully analyzed in previous studies by using the GAL4/UAS system to drive reporter gene expression. Interestingly, 21 Gr-GAL4 drivers showed abdominal ganglion projection, and 18 of these 21 Gr-GAL4 drivers labeled multidendritic neurons of the abdominal wall. 4 drivers also labeled neuronal processes innervating the reproductive organs. The peripheral expression of Gr-GAL4 drivers in abdominal multidendritic neurons or neurons innervating the reproductive organs suggests that these Grs have atypical sensory functions in these organs not limited to conventional taste sensing.

Keywords central projection, Drosophila melanogaster, gustatory receptors, multidendritic neurons, reproductive organs

Article

Research Article

Mol. Cells 2011; 32(4): 375-381

Published online October 31, 2011 https://doi.org/10.1007/s10059-011-0128-1

Copyright © The Korean Society for Molecular and Cellular Biology.

A Systematic Analysis of Drosophila Gustatory Receptor Gene Expression in Abdominal Neurons which Project to the Central Nervous System

Jeong-Ho Park, and Jae Young Kwon*

Department of Biological Sciences, Sungkyunkwan University, Suwon 440-746, Korea

Correspondence to:*Corresponding author: jykwon@skku.edu

Received: June 20, 2011; Revised: July 11, 2011; Accepted: July 12, 2011

Abstract

In Drosophila, the gustatory receptor (Gr) gene family contains 60 family members that encode 68 proteins through alternative splicing. Some gustatory receptors (Grs) are involved in the sensing of sugars, bitter sub-strates, CO2, pheromones, and light. Here, we systemati-cally examined the expression of all 68 Grs in abdominal neurons which project to the abdominal ganglion of the central nervous system using the GAL4/UAS system. Gr gene expression patterns have been successfully analyzed in previous studies by using the GAL4/UAS system to drive reporter gene expression. Interestingly, 21 Gr-GAL4 drivers showed abdominal ganglion projection, and 18 of these 21 Gr-GAL4 drivers labeled multidendritic neurons of the abdominal wall. 4 drivers also labeled neuronal processes innervating the reproductive organs. The peripheral expression of Gr-GAL4 drivers in abdominal multidendritic neurons or neurons innervating the reproductive organs suggests that these Grs have atypical sensory functions in these organs not limited to conventional taste sensing.

Keywords: central projection, Drosophila melanogaster, gustatory receptors, multidendritic neurons, reproductive organs

Mol. Cells
Mar 31, 2023 Vol.46 No.3, pp. 131~189
COVER PICTURE
The physiologically important cytoprotective signaling in normal cells (background area in turquoise) mediated by NRF2 (blue chain) is often hijacked by cancer cells (red ball) in the tumor microenvironment (yellow area). However, the differential roles of NRF2 throughout the multistage carcinogenesis remains largely unresolved (white-colored overlapping misty areas).

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