Sungtae Kim" /> Sungtae Kim, and Juan Carlos Izpisua Belmonte*" /> Sungtae Kim, and Juan Carlos Izpisua Belmonte*. Mol. Cells 2011;32:113-21. https://doi.org/10.1007/s10059-011-1024-4">
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Mol. Cells 2011; 32(2): 113-121

Published online March 24, 2011

https://doi.org/10.1007/s10059-011-1024-4

© The Korean Society for Molecular and Cellular Biology

Pluripotency of Male Germline Stem Cells

Sungtae Kim1, and Juan Carlos Izpisua Belmonte2,3,*

1Department of Chemistry, Korea University, Seoul 136-701, Korea, 2Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, 92037, USA, 3Center of Regenerative Medicine in Barcelona, Dr. Aiguader, Barcelona, Spain

Correspondence to : *Correspondence: belmonte@salk.edu or Izpisua@cmrb.eu

Received: February 10, 2011; Revised: March 6, 2011; Accepted: March 7, 2011

Abstract

The ethical issues and public concerns regarding the use of embryonic stem (ES) cells in human therapy have motivated considerable research into the generation of pluripotent stem cell lines from non-embryonic sources. Numerous reports have shown that pluripotent cells can be generated and derived from germline stem cells (GSCs) in mouse and human testes during in vitro cultivation. The gene expression patterns of these cells are similar to those of ES cells and show the typical self-renewal and differentiation patterns of pluripotent cells in vivo and in vitro. However, the mechanisms underlying the spontaneous dedifferentiation of GSCs remain to be elucidated. Studies to identify master regulators in this reprogramming process are of critical importance for understanding the gene regulatory networks that sustain the cellular status of these cells. The results of such studies would provide a theoretical background for the practical use of these cells in regenerative medicine. Such studies would also help elucidate the molecular mechanisms underlying certain diseases, such as testicular germ cell tumors.

Keywords germline, pluripotency, reprogramming, spermatogonial stem cells, stem cells

Article

Minireview

Mol. Cells 2011; 32(2): 113-121

Published online August 31, 2011 https://doi.org/10.1007/s10059-011-1024-4

Copyright © The Korean Society for Molecular and Cellular Biology.

Pluripotency of Male Germline Stem Cells

Sungtae Kim1, and Juan Carlos Izpisua Belmonte2,3,*

1Department of Chemistry, Korea University, Seoul 136-701, Korea, 2Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, 92037, USA, 3Center of Regenerative Medicine in Barcelona, Dr. Aiguader, Barcelona, Spain

Correspondence to:*Correspondence: belmonte@salk.edu or Izpisua@cmrb.eu

Received: February 10, 2011; Revised: March 6, 2011; Accepted: March 7, 2011

Abstract

The ethical issues and public concerns regarding the use of embryonic stem (ES) cells in human therapy have motivated considerable research into the generation of pluripotent stem cell lines from non-embryonic sources. Numerous reports have shown that pluripotent cells can be generated and derived from germline stem cells (GSCs) in mouse and human testes during in vitro cultivation. The gene expression patterns of these cells are similar to those of ES cells and show the typical self-renewal and differentiation patterns of pluripotent cells in vivo and in vitro. However, the mechanisms underlying the spontaneous dedifferentiation of GSCs remain to be elucidated. Studies to identify master regulators in this reprogramming process are of critical importance for understanding the gene regulatory networks that sustain the cellular status of these cells. The results of such studies would provide a theoretical background for the practical use of these cells in regenerative medicine. Such studies would also help elucidate the molecular mechanisms underlying certain diseases, such as testicular germ cell tumors.

Keywords: germline, pluripotency, reprogramming, spermatogonial stem cells, stem cells

Mol. Cells
Sep 30, 2023 Vol.46 No.9, pp. 527~572
COVER PICTURE
Chronic obstructive pulmonary disease (COPD) is marked by airspace enlargement (emphysema) and small airway fibrosis, leading to airflow obstruction and eventual respiratory failure. Shown is a microphotograph of hematoxylin and eosin (H&E)-stained histological sections of the enlarged alveoli as an indicator of emphysema. Piao et al. (pp. 558-572) demonstrate that recombinant human hyaluronan and proteoglycan link protein 1 (rhHAPLN1) significantly reduces the extended airspaces of the emphysematous alveoli by increasing the levels of TGF-β receptor I and SIRT1/6, as a previously unrecognized mechanism in human alveolar epithelial cells, and consequently mitigates COPD.

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