Seong Yeon Yoo" /> Seok Bean Song" /> Ki Wha Chung*

" /> Seong Yeon Yoo, Nam Soo Cho, Myung Jin Park, Ki Min Seong, Jung Ho Hwang, Seok Bean Song, Myun Soo Han,Won Tae Lee, and Ki Wha Chung*

" /> Seong Yeon Yoo, Nam Soo Cho, Myung Jin Park, Ki Min Seong, Jung Ho Hwang, Seok Bean Song, Myun Soo Han,Won Tae Lee, and Ki Wha Chung*

. Mol. Cells 2011;32:15-9. https://doi.org/10.1007/s10059-011-2288-4">
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Mol. Cells 2011; 32(1): 15-19

Published online May 16, 2011

https://doi.org/10.1007/s10059-011-2288-4

© The Korean Society for Molecular and Cellular Biology

A Large Population Genetic Study of 15 Autosomal Short Tandem Repeat Loci for Establishment of Korean DNA Profile Database

Seong Yeon Yoo1,2,7, Nam Soo Cho1,7, Myung Jin Park3, Ki Min Seong1,2, Jung Ho Hwang1, Seok Bean Song4, Myun Soo Han5, Won Tae Lee6, and Ki Wha Chung2,*

Author Info. +

1Department of Forensic Medicine, Central District Office, National Forensic Service, Daejeon 305-348, Korea, 2Department of Biological Science and Department of Bioinformatics, Kongju National University, Gongju 314-701, Korea, 3Department of Forensic Medicine and Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul 120-752, Korea, 4Institute of Drug Research and Development, College of Pharmacy, Chungnam National University, Daejeon 305-764, Korea, 5DNA Analysis Center, National Forensic Service, Seoul 158-707, Korea, 6Department of Forensic Medicine, Eulji University, Daejeon 301-746, Korea, 7These authors contributed equally to this work.

Correspondence to : *Correspondence: kwchung@kongju.ac.kr

Received: November 17, 2011; Revised: March 31, 2011; Accepted: April 26, 2011

Abstract

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Genotyping of highly polymorphic short tandem repeat (STR) markers is widely used for the genetic identification of individuals in forensic DNA analyses and in paternity disputes. The National DNA Profile Databank recently esta-blished by the DNA Identification Act in Korea contains the computerized STR DNA profiles of individuals convicted of crimes. For the establishment of a large autosomal STR loci population database, 1805 samples were obtained at random from Korean individuals and 15 autosomal STR markers were analyzed using the AmpFlSTR Identifiler PCR Amplification kit. For the 15 autosomal STR markers, no deviations from the Hardy-Weinberg equilibrium were observed. The most informative locus in our data set was the D2S1338 with a discrimination power of 0.9699. The combined matching probability was 1.521 x 10-17. This large STR profile dataset including atypical alleles will be impor-tant for the establishment of the Korean DNA database and for forensic applications.

Keywords autosomal STRs, DNA profile data bank, Korean, microvariant, population database

Article

Research Article

Mol. Cells 2011; 32(1): 15-19

Published online July 31, 2011 https://doi.org/10.1007/s10059-011-2288-4

Copyright © The Korean Society for Molecular and Cellular Biology.

A Large Population Genetic Study of 15 Autosomal Short Tandem Repeat Loci for Establishment of Korean DNA Profile Database

Seong Yeon Yoo1,2,7, Nam Soo Cho1,7, Myung Jin Park3, Ki Min Seong1,2, Jung Ho Hwang1, Seok Bean Song4, Myun Soo Han5, Won Tae Lee6, and Ki Wha Chung2,*

1Department of Forensic Medicine, Central District Office, National Forensic Service, Daejeon 305-348, Korea, 2Department of Biological Science and Department of Bioinformatics, Kongju National University, Gongju 314-701, Korea, 3Department of Forensic Medicine and Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul 120-752, Korea, 4Institute of Drug Research and Development, College of Pharmacy, Chungnam National University, Daejeon 305-764, Korea, 5DNA Analysis Center, National Forensic Service, Seoul 158-707, Korea, 6Department of Forensic Medicine, Eulji University, Daejeon 301-746, Korea, 7These authors contributed equally to this work.

Correspondence to:*Correspondence: kwchung@kongju.ac.kr

Received: November 17, 2011; Revised: March 31, 2011; Accepted: April 26, 2011

Abstract

Genotyping of highly polymorphic short tandem repeat (STR) markers is widely used for the genetic identification of individuals in forensic DNA analyses and in paternity disputes. The National DNA Profile Databank recently esta-blished by the DNA Identification Act in Korea contains the computerized STR DNA profiles of individuals convicted of crimes. For the establishment of a large autosomal STR loci population database, 1805 samples were obtained at random from Korean individuals and 15 autosomal STR markers were analyzed using the AmpFlSTR Identifiler PCR Amplification kit. For the 15 autosomal STR markers, no deviations from the Hardy-Weinberg equilibrium were observed. The most informative locus in our data set was the D2S1338 with a discrimination power of 0.9699. The combined matching probability was 1.521 x 10-17. This large STR profile dataset including atypical alleles will be impor-tant for the establishment of the Korean DNA database and for forensic applications.

Keywords: autosomal STRs, DNA profile data bank, Korean, microvariant, population database

Mol. Cells
Dec 31, 2023 Vol.46 No.12, pp. 727~777
COVER PICTURE
Lee et al. (pp. 757-763), show that disruption of ANKS1A promotes the entry of intraflagellar transport trains into cilia, increasing protein transport and forming extracellular vesicles (ECVs). This figure illustrates the abundance of ECVs along the cilia of primary ependymal cells derived from ANKS1A KO mice.
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