Do Hee Lee Youra Lee" /> Do Hee Lee Youra Lee, Joohyun Ryu, Sung Goo Park, Sayeon Cho, Je-Jung Lee, Chan Choi, and Byoung Chul Park*

" /> Do Hee Lee Youra Lee, Joohyun Ryu, Sung Goo Park, Sayeon Cho, Je-Jung Lee, Chan Choi, and Byoung Chul Park*

. Mol. Cells 2011;31:563-71. https://doi.org/10.1007/s10059-011-1053-z">
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Mol. Cells 2011; 31(6): 563-571

Published online April 20, 2011

https://doi.org/10.1007/s10059-011-1053-z

© The Korean Society for Molecular and Cellular Biology

Identification of Proteins Differentially Expressed in Gastric Cancer Cells with High Metastatic Potential for Invasion to Lymph Nodes

Do Hee Lee1,6, Youra Lee2,6, Joohyun Ryu2, Sung Goo Park2, Sayeon Cho3, Je-Jung Lee4, Chan Choi5, and Byoung Chul Park2,*

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1Department of Biotechnology, Seoul Women’s University, Seoul 139-774, Korea, 2Medical Proteomics Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-806, Korea, 3College of Pharmacy, Chung-Ang University, Seoul 156-756, Korea, 4Department of Hematology-Oncology, Chonnam National University Medical School, Gwangju 501-746, Korea, 5Department of Pathology, Chonnam National University Medical School, Gwangju 501-746, Korea, 6These authors contributed equally to this work.

Correspondence to : *Correspondence: parkbc@kribb.re.kr

Received: March 16, 2011; Accepted: March 28, 2011

Abstract

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In a search for proteins involved in cancer metastasis, we analyzed proteomes of the human gastric cancer cell OCUM-2M and its metastatic subline OCUM-2MLN. We observed that aspartate aminotransferase (AAT), D-site binding protein (DBP), and anterior gradient protein 2 (AGR2) are differentially expressed in metastatic OCUM-2MLN cells. Measurement of protein expression in clinical samples indicated that DBP and AAT are also down-regulated in metastatic adenocarcinoma. Additionally, uro-kinase-type tissue plasminogen activator is up-regulated in OCUM-2MLN cells and also in metastatic gastric cancer samples. Collectively, these results raise a possibility that AAT, DBP and AGR2 are functionally implicated in the invasiveness of gastric cancer cells.

Keywords AAT, AGR2, DBP, gastric cancer, metastasis, proteome

Article

Research Article

Mol. Cells 2011; 31(6): 563-571

Published online June 30, 2011 https://doi.org/10.1007/s10059-011-1053-z

Copyright © The Korean Society for Molecular and Cellular Biology.

Identification of Proteins Differentially Expressed in Gastric Cancer Cells with High Metastatic Potential for Invasion to Lymph Nodes

Do Hee Lee1,6, Youra Lee2,6, Joohyun Ryu2, Sung Goo Park2, Sayeon Cho3, Je-Jung Lee4, Chan Choi5, and Byoung Chul Park2,*

1Department of Biotechnology, Seoul Women’s University, Seoul 139-774, Korea, 2Medical Proteomics Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-806, Korea, 3College of Pharmacy, Chung-Ang University, Seoul 156-756, Korea, 4Department of Hematology-Oncology, Chonnam National University Medical School, Gwangju 501-746, Korea, 5Department of Pathology, Chonnam National University Medical School, Gwangju 501-746, Korea, 6These authors contributed equally to this work.

Correspondence to:*Correspondence: parkbc@kribb.re.kr

Received: March 16, 2011; Accepted: March 28, 2011

Abstract

In a search for proteins involved in cancer metastasis, we analyzed proteomes of the human gastric cancer cell OCUM-2M and its metastatic subline OCUM-2MLN. We observed that aspartate aminotransferase (AAT), D-site binding protein (DBP), and anterior gradient protein 2 (AGR2) are differentially expressed in metastatic OCUM-2MLN cells. Measurement of protein expression in clinical samples indicated that DBP and AAT are also down-regulated in metastatic adenocarcinoma. Additionally, uro-kinase-type tissue plasminogen activator is up-regulated in OCUM-2MLN cells and also in metastatic gastric cancer samples. Collectively, these results raise a possibility that AAT, DBP and AGR2 are functionally implicated in the invasiveness of gastric cancer cells.

Keywords: AAT, AGR2, DBP, gastric cancer, metastasis, proteome

Mol. Cells
Jun 30, 2023 Vol.46 No.6, pp. 329~398
COVER PICTURE
The cellular proteostasis network is adaptively modulated upon cellular stress, thereby protecting cells from proteostasis collapse. Heat shock induces the translocation of misfolded proteins and the chaperone protein HSP70 into nucleolus, where nuclear protein quality control primarily occurs. Nuclear RNA export factor 1 (green), nucleolar protein fibrillarin (red), and nuclei (blue) were visualized in NIH3T3 cells under basal (left) and heat shock (right) conditions (Park et al., pp. 374-386).
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