Mol. Cells 2011; 31(6): 563-571
Published online April 20, 2011
https://doi.org/10.1007/s10059-011-1053-z
© The Korean Society for Molecular and Cellular Biology
Do Hee Lee1,6, Youra Lee2,6, Joohyun Ryu2, Sung Goo Park2, Sayeon Cho3, Je-Jung Lee4, Chan Choi5, and Byoung Chul Park2,*
Correspondence to : *Correspondence: parkbc@kribb.re.kr
In a search for proteins involved in cancer metastasis, we analyzed proteomes of the human gastric cancer cell OCUM-2M and its metastatic subline OCUM-2MLN. We observed that aspartate aminotransferase (AAT), D-site binding protein (DBP), and anterior gradient protein 2 (AGR2) are differentially expressed in metastatic OCUM-2MLN cells. Measurement of protein expression in clinical samples indicated that DBP and AAT are also down-regulated in metastatic adenocarcinoma. Additionally, uro-kinase-type tissue plasminogen activator is up-regulated in OCUM-2MLN cells and also in metastatic gastric cancer samples. Collectively, these results raise a possibility that AAT, DBP and AGR2 are functionally implicated in the invasiveness of gastric cancer cells.
Keywords AAT, AGR2, DBP, gastric cancer, metastasis, proteome
Mol. Cells 2011; 31(6): 563-571
Published online June 30, 2011 https://doi.org/10.1007/s10059-011-1053-z
Copyright © The Korean Society for Molecular and Cellular Biology.
Do Hee Lee1,6, Youra Lee2,6, Joohyun Ryu2, Sung Goo Park2, Sayeon Cho3, Je-Jung Lee4, Chan Choi5, and Byoung Chul Park2,*
1Department of Biotechnology, Seoul Women’s University, Seoul 139-774, Korea, 2Medical Proteomics Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-806, Korea, 3College of Pharmacy, Chung-Ang University, Seoul 156-756, Korea, 4Department of Hematology-Oncology, Chonnam National University Medical School, Gwangju 501-746, Korea, 5Department of Pathology, Chonnam National University Medical School, Gwangju 501-746, Korea, 6These authors contributed equally to this work.
Correspondence to:*Correspondence: parkbc@kribb.re.kr
In a search for proteins involved in cancer metastasis, we analyzed proteomes of the human gastric cancer cell OCUM-2M and its metastatic subline OCUM-2MLN. We observed that aspartate aminotransferase (AAT), D-site binding protein (DBP), and anterior gradient protein 2 (AGR2) are differentially expressed in metastatic OCUM-2MLN cells. Measurement of protein expression in clinical samples indicated that DBP and AAT are also down-regulated in metastatic adenocarcinoma. Additionally, uro-kinase-type tissue plasminogen activator is up-regulated in OCUM-2MLN cells and also in metastatic gastric cancer samples. Collectively, these results raise a possibility that AAT, DBP and AGR2 are functionally implicated in the invasiveness of gastric cancer cells.
Keywords: AAT, AGR2, DBP, gastric cancer, metastasis, proteome
Christopher J. Occhiuto, Jessica A. Moerland, Ana S. Leal, Kathleen A. Gallo, and Karen T. Liby
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