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Mol. Cells 2011; 31(6): 491-496

Published online February 23, 2011

https://doi.org/10.1007/s10059-011-1004-8

© The Korean Society for Molecular and Cellular Biology

The Coded Functions of Noncoding RNAs for Gene Regulation

Sojin An, and Ji-Joon Song*

Author Info. +

Structural Biology Laboratory of Epigenetics, Department of Biological Sciences, Graduate School of Nanoscience and Technology (World Class University), KI Institute for the BioCentury, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea

Correspondence to : *Correspondence: songj@kaist.ac.kr

Received: January 5, 2011; Revised: January 31, 2011; Accepted: February 1, 2011

Abstract

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For eukaryotes, fine tuning of gene expression is necessary to coordinate complex genetic information. Recent studies have shown that noncoding RNAs (ncRNAs) play central roles in this process. For example, ncRNAs participate in multiple diverse functions such as mRNA degradation, epigenetic regulation and alternative splicing. The findings regarding this new player in gene regulation suggest that the mechanism of gene regulation is much more complicated and subtle than previously thought. In this review, new findings concerning the role of ncRNAs in gene regulation are discussed.

Keywords chromatin, gene regulation, RNA

Article

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Mol. Cells 2011; 31(6): 491-496

Published online June 30, 2011 https://doi.org/10.1007/s10059-011-1004-8

Copyright © The Korean Society for Molecular and Cellular Biology.

The Coded Functions of Noncoding RNAs for Gene Regulation

Sojin An, and Ji-Joon Song*

Structural Biology Laboratory of Epigenetics, Department of Biological Sciences, Graduate School of Nanoscience and Technology (World Class University), KI Institute for the BioCentury, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea

Correspondence to:*Correspondence: songj@kaist.ac.kr

Received: January 5, 2011; Revised: January 31, 2011; Accepted: February 1, 2011

Abstract

For eukaryotes, fine tuning of gene expression is necessary to coordinate complex genetic information. Recent studies have shown that noncoding RNAs (ncRNAs) play central roles in this process. For example, ncRNAs participate in multiple diverse functions such as mRNA degradation, epigenetic regulation and alternative splicing. The findings regarding this new player in gene regulation suggest that the mechanism of gene regulation is much more complicated and subtle than previously thought. In this review, new findings concerning the role of ncRNAs in gene regulation are discussed.

Keywords: chromatin, gene regulation, RNA

Mol. Cells
May 31, 2023 Vol.46 No.5, pp. 259~328
COVER PICTURE
The alpha-helices in the lamin filaments are depicted as coils, with different subdomains distinguished by various colors. Coil 1a is represented by magenta, coil 1b by yellow, L2 by green, coil 2a by white, coil 2b by brown, stutter by cyan, coil 2c by dark blue, and the lamin Ig-like domain by grey. In the background, cells are displayed, with the cytosol depicted in green and the nucleus in blue (Ahn et al., pp. 309-318).
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