Thi-Minh-Tho Dam" /> Thi-Minh-Tho Dam, Hyun-Taek Kim, Hyun-Yi Moon, Kyu-Seok Hwang, Yun-Mi Jeong, Kwan-Hee You, Jeong-Soo Lee, and Cheol-Hee Kim*" /> Thi-Minh-Tho Dam, Hyun-Taek Kim, Hyun-Yi Moon, Kyu-Seok Hwang, Yun-Mi Jeong, Kwan-Hee You, Jeong-Soo Lee, and Cheol-Hee Kim*. Mol. Cells 2011;31:471-5. https://doi.org/10.1007/s10059-011-0052-4">
Mol. Cells 2011; 31(5): 471-475
Published online March 24, 2011
https://doi.org/10.1007/s10059-011-0052-4
© The Korean Society for Molecular and Cellular Biology
Correspondence to : *Correspondence: zebrakim@cnu.ac.kr
Scratch (scrt) genes are neural-specific in mammals, but their homologues have not been well studied in non-mammalian vertebrates. In this report, we isolated three zebrafish scrt genes, scratch1a (scrt1a), scratch1b (scrt1b), and scratch2 (scrt2), which belong to the Snail super-family of zinc finger transcription factors. Spatiotemporal expression analysis revealed that scrt1a and scrt2 were initially detected in the central nervous system (CNS) during early somitogenesis while scrt1b was first detectable in neuronal clusters in the brain during late somitogenesis. Interestingly, scrt-expressing cells largely overlapped with huC-positive differentiating neurons and partially with neurogenin1-positive neuronal precursor cells. In addition, scrt-expressing cells were dramatically increased in mind bomb, a neurogenic mutant. Taken together, these results suggest that each zebrafish scrt gene is specifically ex-pressed in neuronal cells and may be involved in differentiation of distinct neuronal populations in the vertebrate nervous system.
Keywords central nervous system, neuronal differentiation, scratch, zebrafish
Mol. Cells 2011; 31(5): 471-475
Published online May 31, 2011 https://doi.org/10.1007/s10059-011-0052-4
Copyright © The Korean Society for Molecular and Cellular Biology.
Thi-Minh-Tho Dam1,3, Hyun-Taek Kim1,3, Hyun-Yi Moon1, Kyu-Seok Hwang1, Yun-Mi Jeong1, Kwan-Hee You1, Jeong-Soo Lee2, and Cheol-Hee Kim1,*
1Department of Biology, Chungnam National University, Daejeon 305-764, Korea, 2Aging Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-719, Korea, 3These authors equally contributed to this work.
Correspondence to:*Correspondence: zebrakim@cnu.ac.kr
Scratch (scrt) genes are neural-specific in mammals, but their homologues have not been well studied in non-mammalian vertebrates. In this report, we isolated three zebrafish scrt genes, scratch1a (scrt1a), scratch1b (scrt1b), and scratch2 (scrt2), which belong to the Snail super-family of zinc finger transcription factors. Spatiotemporal expression analysis revealed that scrt1a and scrt2 were initially detected in the central nervous system (CNS) during early somitogenesis while scrt1b was first detectable in neuronal clusters in the brain during late somitogenesis. Interestingly, scrt-expressing cells largely overlapped with huC-positive differentiating neurons and partially with neurogenin1-positive neuronal precursor cells. In addition, scrt-expressing cells were dramatically increased in mind bomb, a neurogenic mutant. Taken together, these results suggest that each zebrafish scrt gene is specifically ex-pressed in neuronal cells and may be involved in differentiation of distinct neuronal populations in the vertebrate nervous system.
Keywords: central nervous system, neuronal differentiation, scratch, zebrafish
Thi-Minh-Tho Dam, Hyun-Taek Kim, Hyun-Yi Moon, Kyu-Seok Hwang, Yun-Mi Jeong, Kwan-Hee You, Jeong-Soo Lee, and Cheol-Hee Kim
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