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Mol. Cells 2011; 31(5): 423-429

Published online February 22, 2011

https://doi.org/10.1007/s10059-011-0256-7

© The Korean Society for Molecular and Cellular Biology

Inonotus obliquus Protects against Oxidative Stress-Induced Apoptosis and Premature Senescence

Jong Seok Yun, Jung Woon Pahk, Jong Seok Lee, Won Cheol Shin, Shin Young Lee, and Eock Kee Hong*

Department of Bioengineering and Technology, Kangwon National University, Chuncheon 200-701, Korea

Correspondence to : *Correspondence: ekhong@kangwon.ac.kr

Received: October 13, 2011; Accepted: January 31, 2011

Abstract

In this study, we investigated the cytoprotective effects of Inonotus obliquus against oxidative stress-induced apoptosis and premature senescence. Pretreatment with I. obliquus scavenged intracellular ROS and prevented lipid peroxidation in hydrogen peroxide-treated human fibroblasts. As a result, I. obliquus exerted protective effects against hydrogen peroxide-induced apoptosis and premature senescence in human fibroblasts. In addition, I. obliquus suppressed UV-induced morphologic skin changes, such as skin thickening and wrinkle formation, in hairless mice in vivo and increased collagen synthesis through inhibition of MMP-1 and MMP-9 activities in hydrogen peroxide-treated human fibroblasts. Taken together, these results demonstrate that I. obliquus can prevent the aging process by attenuating oxidative stress in a model of stress-induced premature senes-cence.

Keywords antioxidant, apoptosis, Inonotus obliquus, reactive oxygen species (ROS), stress-induced premature senescence

Article

Research Article

Mol. Cells 2011; 31(5): 423-429

Published online May 31, 2011 https://doi.org/10.1007/s10059-011-0256-7

Copyright © The Korean Society for Molecular and Cellular Biology.

Inonotus obliquus Protects against Oxidative Stress-Induced Apoptosis and Premature Senescence

Jong Seok Yun, Jung Woon Pahk, Jong Seok Lee, Won Cheol Shin, Shin Young Lee, and Eock Kee Hong*

Department of Bioengineering and Technology, Kangwon National University, Chuncheon 200-701, Korea

Correspondence to:*Correspondence: ekhong@kangwon.ac.kr

Received: October 13, 2011; Accepted: January 31, 2011

Abstract

In this study, we investigated the cytoprotective effects of Inonotus obliquus against oxidative stress-induced apoptosis and premature senescence. Pretreatment with I. obliquus scavenged intracellular ROS and prevented lipid peroxidation in hydrogen peroxide-treated human fibroblasts. As a result, I. obliquus exerted protective effects against hydrogen peroxide-induced apoptosis and premature senescence in human fibroblasts. In addition, I. obliquus suppressed UV-induced morphologic skin changes, such as skin thickening and wrinkle formation, in hairless mice in vivo and increased collagen synthesis through inhibition of MMP-1 and MMP-9 activities in hydrogen peroxide-treated human fibroblasts. Taken together, these results demonstrate that I. obliquus can prevent the aging process by attenuating oxidative stress in a model of stress-induced premature senes-cence.

Keywords: antioxidant, apoptosis, Inonotus obliquus, reactive oxygen species (ROS), stress-induced premature senescence

Mol. Cells
Feb 28, 2023 Vol.46 No.2, pp. 69~129
COVER PICTURE
The bulk tissue is a heterogeneous mixture of various cell types, which is depicted as a skein of intertwined threads with diverse colors each of which represents a unique cell type. Single-cell omics analysis untangles efficiently the skein according to the color by providing information of molecules at individual cells and interpretation of such information based on different cell types. The molecules that can be profiled at the individual cell by single-cell omics analysis includes DNA (bottom middle), RNA (bottom right), and protein (bottom left). This special issue reviews single-cell technologies and computational methods that have been developed for the single-cell omics analysis and how they have been applied to improve our understanding of the underlying mechanisms of biological and pathological phenomena at the single-cell level.

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