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Mol. Cells 2011; 31(5): 423-429

Published online February 22, 2011

https://doi.org/10.1007/s10059-011-0256-7

© The Korean Society for Molecular and Cellular Biology

Inonotus obliquus Protects against Oxidative Stress-Induced Apoptosis and Premature Senescence

Jong Seok Yun, Jung Woon Pahk, Jong Seok Lee, Won Cheol Shin, Shin Young Lee, and Eock Kee Hong*

Department of Bioengineering and Technology, Kangwon National University, Chuncheon 200-701, Korea

Correspondence to : *Correspondence: ekhong@kangwon.ac.kr

Received: October 13, 2011; Accepted: January 31, 2011

Abstract

In this study, we investigated the cytoprotective effects of Inonotus obliquus against oxidative stress-induced apoptosis and premature senescence. Pretreatment with I. obliquus scavenged intracellular ROS and prevented lipid peroxidation in hydrogen peroxide-treated human fibroblasts. As a result, I. obliquus exerted protective effects against hydrogen peroxide-induced apoptosis and premature senescence in human fibroblasts. In addition, I. obliquus suppressed UV-induced morphologic skin changes, such as skin thickening and wrinkle formation, in hairless mice in vivo and increased collagen synthesis through inhibition of MMP-1 and MMP-9 activities in hydrogen peroxide-treated human fibroblasts. Taken together, these results demonstrate that I. obliquus can prevent the aging process by attenuating oxidative stress in a model of stress-induced premature senes-cence.

Keywords antioxidant, apoptosis, Inonotus obliquus, reactive oxygen species (ROS), stress-induced premature senescence

Article

Research Article

Mol. Cells 2011; 31(5): 423-429

Published online May 31, 2011 https://doi.org/10.1007/s10059-011-0256-7

Copyright © The Korean Society for Molecular and Cellular Biology.

Inonotus obliquus Protects against Oxidative Stress-Induced Apoptosis and Premature Senescence

Jong Seok Yun, Jung Woon Pahk, Jong Seok Lee, Won Cheol Shin, Shin Young Lee, and Eock Kee Hong*

Department of Bioengineering and Technology, Kangwon National University, Chuncheon 200-701, Korea

Correspondence to:*Correspondence: ekhong@kangwon.ac.kr

Received: October 13, 2011; Accepted: January 31, 2011

Abstract

In this study, we investigated the cytoprotective effects of Inonotus obliquus against oxidative stress-induced apoptosis and premature senescence. Pretreatment with I. obliquus scavenged intracellular ROS and prevented lipid peroxidation in hydrogen peroxide-treated human fibroblasts. As a result, I. obliquus exerted protective effects against hydrogen peroxide-induced apoptosis and premature senescence in human fibroblasts. In addition, I. obliquus suppressed UV-induced morphologic skin changes, such as skin thickening and wrinkle formation, in hairless mice in vivo and increased collagen synthesis through inhibition of MMP-1 and MMP-9 activities in hydrogen peroxide-treated human fibroblasts. Taken together, these results demonstrate that I. obliquus can prevent the aging process by attenuating oxidative stress in a model of stress-induced premature senes-cence.

Keywords: antioxidant, apoptosis, Inonotus obliquus, reactive oxygen species (ROS), stress-induced premature senescence

Mol. Cells
Sep 30, 2023 Vol.46 No.9, pp. 527~572
COVER PICTURE
Chronic obstructive pulmonary disease (COPD) is marked by airspace enlargement (emphysema) and small airway fibrosis, leading to airflow obstruction and eventual respiratory failure. Shown is a microphotograph of hematoxylin and eosin (H&E)-stained histological sections of the enlarged alveoli as an indicator of emphysema. Piao et al. (pp. 558-572) demonstrate that recombinant human hyaluronan and proteoglycan link protein 1 (rhHAPLN1) significantly reduces the extended airspaces of the emphysematous alveoli by increasing the levels of TGF-β receptor I and SIRT1/6, as a previously unrecognized mechanism in human alveolar epithelial cells, and consequently mitigates COPD.

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