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Mol. Cells 2011; 31(4): 379-383

Published online February 22, 2011

https://doi.org/10.1007/s10059-011-0319-9

© The Korean Society for Molecular and Cellular Biology

Spontaneous Reactive Astrogliosis in the Dentate Gyrus of Bax-Deficient Mice

Tae Woo Kim, Hyun Kim, and Woong Sun*

Department of Anatomy, Brain Korea 21 Program, Korea University College of Medicine, Seoul 136-705, Korea

Correspondence to : *Correspondence: woongsun@korea.ac.kr

Received: December 24, 2011; Revised: January 25, 2011; Accepted: January 31, 2011

Abstract

Astrocytes play critical roles in many aspects of brain functions via modulation of neurotransmission, metabol-ism, and structural remodeling in response to physiological or pathological stimuli. Activation of astrocytes is a common phenomenon in many brain pathologies such as stroke, trauma, and neurodegenerative diseases. In this study, we found that gene deletion of the pro-apoptotic gene Bax (Bax-knockout) resulted in a spontaneous reactive astrogliosis in the dentate gyrus, as evidenced by the increased number/volume of astrocytes and cytoplasmic localization of the Olig2 protein. On the other hand, there was no evidence for microglial activation in the dentate gyrus of Bax-knockout mice. Previously, we reported that Bax-knockout mice failed to execute programmed cell death of adult-produced neurons, but the surplus neurons eventually impaired normal synaptic connections and dendritic arborization of dentate gyrus neurons. Therefore, we propose that the reactive astrocytes in the Bax-knockout mice may play a role in tissue remodeling of the dentate gyrus following a failure in the programmed cell death of adult-produced neurons.

Keywords astrogliosis, Bax, microglial activation, neurogenesis, progrmmed cell death

Article

Research Article

Mol. Cells 2011; 31(4): 379-383

Published online April 30, 2011 https://doi.org/10.1007/s10059-011-0319-9

Copyright © The Korean Society for Molecular and Cellular Biology.

Spontaneous Reactive Astrogliosis in the Dentate Gyrus of Bax-Deficient Mice

Tae Woo Kim, Hyun Kim, and Woong Sun*

Department of Anatomy, Brain Korea 21 Program, Korea University College of Medicine, Seoul 136-705, Korea

Correspondence to:*Correspondence: woongsun@korea.ac.kr

Received: December 24, 2011; Revised: January 25, 2011; Accepted: January 31, 2011

Abstract

Astrocytes play critical roles in many aspects of brain functions via modulation of neurotransmission, metabol-ism, and structural remodeling in response to physiological or pathological stimuli. Activation of astrocytes is a common phenomenon in many brain pathologies such as stroke, trauma, and neurodegenerative diseases. In this study, we found that gene deletion of the pro-apoptotic gene Bax (Bax-knockout) resulted in a spontaneous reactive astrogliosis in the dentate gyrus, as evidenced by the increased number/volume of astrocytes and cytoplasmic localization of the Olig2 protein. On the other hand, there was no evidence for microglial activation in the dentate gyrus of Bax-knockout mice. Previously, we reported that Bax-knockout mice failed to execute programmed cell death of adult-produced neurons, but the surplus neurons eventually impaired normal synaptic connections and dendritic arborization of dentate gyrus neurons. Therefore, we propose that the reactive astrocytes in the Bax-knockout mice may play a role in tissue remodeling of the dentate gyrus following a failure in the programmed cell death of adult-produced neurons.

Keywords: astrogliosis, Bax, microglial activation, neurogenesis, progrmmed cell death

Mol. Cells
Nov 30, 2023 Vol.46 No.11, pp. 655~725
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Kim et al. (pp. 710-724) demonstrated that a pathogen-derived Ralstonia pseudosolanacearum type III effector RipL delays flowering time and enhances susceptibility to bacterial infection in Arabidopsis thaliana. Shown is the RipL-expressing Arabidopsis plant, which displays general dampening of the transcriptional program during pathogen infection, grown in long-day conditions.

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