Mol. Cells 2011; 31(4): 379-383
Published online February 22, 2011
https://doi.org/10.1007/s10059-011-0319-9
© The Korean Society for Molecular and Cellular Biology
Correspondence to : *Correspondence: woongsun@korea.ac.kr
Astrocytes play critical roles in many aspects of brain functions via modulation of neurotransmission, metabol-ism, and structural remodeling in response to physiological or pathological stimuli. Activation of astrocytes is a common phenomenon in many brain pathologies such as stroke, trauma, and neurodegenerative diseases. In this study, we found that gene deletion of the pro-apoptotic gene Bax (Bax-knockout) resulted in a spontaneous reactive astrogliosis in the dentate gyrus, as evidenced by the increased number/volume of astrocytes and cytoplasmic localization of the Olig2 protein. On the other hand, there was no evidence for microglial activation in the dentate gyrus of Bax-knockout mice. Previously, we reported that Bax-knockout mice failed to execute programmed cell death of adult-produced neurons, but the surplus neurons eventually impaired normal synaptic connections and dendritic arborization of dentate gyrus neurons. Therefore, we propose that the reactive astrocytes in the Bax-knockout mice may play a role in tissue remodeling of the dentate gyrus following a failure in the programmed cell death of adult-produced neurons.
Keywords astrogliosis, Bax, microglial activation, neurogenesis, progrmmed cell death
Mol. Cells 2011; 31(4): 379-383
Published online April 30, 2011 https://doi.org/10.1007/s10059-011-0319-9
Copyright © The Korean Society for Molecular and Cellular Biology.
Tae Woo Kim, Hyun Kim, and Woong Sun*
Department of Anatomy, Brain Korea 21 Program, Korea University College of Medicine, Seoul 136-705, Korea
Correspondence to:*Correspondence: woongsun@korea.ac.kr
Astrocytes play critical roles in many aspects of brain functions via modulation of neurotransmission, metabol-ism, and structural remodeling in response to physiological or pathological stimuli. Activation of astrocytes is a common phenomenon in many brain pathologies such as stroke, trauma, and neurodegenerative diseases. In this study, we found that gene deletion of the pro-apoptotic gene Bax (Bax-knockout) resulted in a spontaneous reactive astrogliosis in the dentate gyrus, as evidenced by the increased number/volume of astrocytes and cytoplasmic localization of the Olig2 protein. On the other hand, there was no evidence for microglial activation in the dentate gyrus of Bax-knockout mice. Previously, we reported that Bax-knockout mice failed to execute programmed cell death of adult-produced neurons, but the surplus neurons eventually impaired normal synaptic connections and dendritic arborization of dentate gyrus neurons. Therefore, we propose that the reactive astrocytes in the Bax-knockout mice may play a role in tissue remodeling of the dentate gyrus following a failure in the programmed cell death of adult-produced neurons.
Keywords: astrogliosis, Bax, microglial activation, neurogenesis, progrmmed cell death
Khadija Habib, Kausik Bishayee, Jieun Kang, Ali Sadra*, and Sung-Oh Huh*
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