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Mol. Cells 2011; 31(4): 379-383

Published online April 30, 2011

https://doi.org/10.1007/s10059-011-0319-9

© The Korean Society for Molecular and Cellular Biology

Spontaneous Reactive Astrogliosis in the Dentate Gyrus of Bax-Deficient Mice

Tae Woo Kim, Hyun Kim, and Woong Sun*

Department of Anatomy, Brain Korea 21 Program, Korea University College of Medicine, Seoul 136-705, Korea

Correspondence to : *Correspondence: woongsun@korea.ac.kr

Received: December 24, 2011; Revised: January 25, 2011; Accepted: January 31, 2011

Abstract

Astrocytes play critical roles in many aspects of brain functions via modulation of neurotransmission, metabol-ism, and structural remodeling in response to physiological or pathological stimuli. Activation of astrocytes is a common phenomenon in many brain pathologies such as stroke, trauma, and neurodegenerative diseases. In this study, we found that gene deletion of the pro-apoptotic gene Bax (Bax-knockout) resulted in a spontaneous reactive astrogliosis in the dentate gyrus, as evidenced by the increased number/volume of astrocytes and cytoplasmic localization of the Olig2 protein. On the other hand, there was no evidence for microglial activation in the dentate gyrus of Bax-knockout mice. Previously, we reported that Bax-knockout mice failed to execute programmed cell death of adult-produced neurons, but the surplus neurons eventually impaired normal synaptic connections and dendritic arborization of dentate gyrus neurons. Therefore, we propose that the reactive astrocytes in the Bax-knockout mice may play a role in tissue remodeling of the dentate gyrus following a failure in the programmed cell death of adult-produced neurons.

Keywords astrogliosis, Bax, microglial activation, neurogenesis, progrmmed cell death

Article

Research Article

Mol. Cells 2011; 31(4): 379-383

Published online April 30, 2011 https://doi.org/10.1007/s10059-011-0319-9

Copyright © The Korean Society for Molecular and Cellular Biology.

Spontaneous Reactive Astrogliosis in the Dentate Gyrus of Bax-Deficient Mice

Tae Woo Kim, Hyun Kim, and Woong Sun*

Department of Anatomy, Brain Korea 21 Program, Korea University College of Medicine, Seoul 136-705, Korea

Correspondence to:*Correspondence: woongsun@korea.ac.kr

Received: December 24, 2011; Revised: January 25, 2011; Accepted: January 31, 2011

Abstract

Astrocytes play critical roles in many aspects of brain functions via modulation of neurotransmission, metabol-ism, and structural remodeling in response to physiological or pathological stimuli. Activation of astrocytes is a common phenomenon in many brain pathologies such as stroke, trauma, and neurodegenerative diseases. In this study, we found that gene deletion of the pro-apoptotic gene Bax (Bax-knockout) resulted in a spontaneous reactive astrogliosis in the dentate gyrus, as evidenced by the increased number/volume of astrocytes and cytoplasmic localization of the Olig2 protein. On the other hand, there was no evidence for microglial activation in the dentate gyrus of Bax-knockout mice. Previously, we reported that Bax-knockout mice failed to execute programmed cell death of adult-produced neurons, but the surplus neurons eventually impaired normal synaptic connections and dendritic arborization of dentate gyrus neurons. Therefore, we propose that the reactive astrocytes in the Bax-knockout mice may play a role in tissue remodeling of the dentate gyrus following a failure in the programmed cell death of adult-produced neurons.

Keywords: astrogliosis, Bax, microglial activation, neurogenesis, progrmmed cell death

Mol. Cells
Aug 31, 2022 Vol.45 No.8, pp. 513~602
COVER PICTURE
Cryo-EM structure of human porphyrin transporter ABCB6 (main figure) shows that binding of hemin (inset, magenta) in concert with two glutathione molecules (cyan) primes ABCB6 for high ATP turnover (Kim et al., pp. 575-587).

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