Hyun Nam" /> Hyun Nam, Jaewon Kim, Jaewan Park, Joo-Cheol Park, Jung-Wook Kim, Byoung-Moo Seo, Jae Cheoun Lee, and Gene Lee*

" /> Hyun Nam, Jaewon Kim, Jaewan Park, Joo-Cheol Park, Jung-Wook Kim, Byoung-Moo Seo, Jae Cheoun Lee, and Gene Lee*

. Mol. Cells 2011;31:355-60. https://doi.org/10.1007/s10059-011-0045-3">
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Mol. Cells 2011; 31(4): 355-360

Published online April 30, 2011

https://doi.org/10.1007/s10059-011-0045-3

© The Korean Society for Molecular and Cellular Biology

Expression Profile of the Stem Cell Markers in Human Hertwig's Epithelial Root Sheath/Epithelial Rests of Malassez Cells

Hyun Nam, Jaewon Kim, Jaewan Park, Joo-Cheol Park1, Jung-Wook Kim2, Byoung-Moo Seo3, Jae Cheoun Lee4, and Gene Lee*

Laboratory of Molecular Genetics, Dental Research Institute, School of Dentistry, Seoul National University, Seoul 110-749, Korea, 1Department of Oral Histology-Developmental Biology, School of Dentistry, Seoul National University, Seoul 110-749, Korea, 2Department of Pediatric Dentistry, School of Dentistry, Seoul National University, Seoul 110-749, Korea, 3Department of Oral and Maxillofacial Surgery, School of Dentistry, Seoul National University, Seoul 110-749, Korea, 4Children’s Dental Center and CDC Baby Tooth Stem Cell Bank, Seoul 135-953, Korea

Correspondence to : *Correspondence: genelee@plaza.snu.ac.kr

Received: November 5, 2011; Revised: January 14, 2011; Accepted: January 14, 2011

Abstract

Hertwig’s epithelial root sheath/Epithelial rests of Malassez (HERS/ERM) cells are unique epithelial cells in the periodontal ligament. They remain in periodontal tissues through- out the adult life, and it is expected that their functional role is to maintain the homeostasis of the periodontium through reciprocal interactions with other periodontal cells. In this study, we investigated whether HERS/ERM cells have primitive stem cell characteristics: those of embryonic stem cells as well as of epithelial stem cells. Primary HERS/ERM cells had typical epithelial cell morphology and characteristics and they maintained for more than five passages. They expressed epithelial stem cell-related genes: ABCG2,

Keywords embryonic stem cells, epithelial stem cells, Hertwig’s epithelial root sheath/Epithelial rests of Malassez cells, stem cell markers

Article

Research Article

Mol. Cells 2011; 31(4): 355-360

Published online April 30, 2011 https://doi.org/10.1007/s10059-011-0045-3

Copyright © The Korean Society for Molecular and Cellular Biology.

Expression Profile of the Stem Cell Markers in Human Hertwig's Epithelial Root Sheath/Epithelial Rests of Malassez Cells

Hyun Nam, Jaewon Kim, Jaewan Park, Joo-Cheol Park1, Jung-Wook Kim2, Byoung-Moo Seo3, Jae Cheoun Lee4, and Gene Lee*

Laboratory of Molecular Genetics, Dental Research Institute, School of Dentistry, Seoul National University, Seoul 110-749, Korea, 1Department of Oral Histology-Developmental Biology, School of Dentistry, Seoul National University, Seoul 110-749, Korea, 2Department of Pediatric Dentistry, School of Dentistry, Seoul National University, Seoul 110-749, Korea, 3Department of Oral and Maxillofacial Surgery, School of Dentistry, Seoul National University, Seoul 110-749, Korea, 4Children’s Dental Center and CDC Baby Tooth Stem Cell Bank, Seoul 135-953, Korea

Correspondence to:*Correspondence: genelee@plaza.snu.ac.kr

Received: November 5, 2011; Revised: January 14, 2011; Accepted: January 14, 2011

Abstract

Hertwig’s epithelial root sheath/Epithelial rests of Malassez (HERS/ERM) cells are unique epithelial cells in the periodontal ligament. They remain in periodontal tissues through- out the adult life, and it is expected that their functional role is to maintain the homeostasis of the periodontium through reciprocal interactions with other periodontal cells. In this study, we investigated whether HERS/ERM cells have primitive stem cell characteristics: those of embryonic stem cells as well as of epithelial stem cells. Primary HERS/ERM cells had typical epithelial cell morphology and characteristics and they maintained for more than five passages. They expressed epithelial stem cell-related genes: ABCG2,

Keywords: embryonic stem cells, epithelial stem cells, Hertwig’s epithelial root sheath/Epithelial rests of Malassez cells, stem cell markers

Mol. Cells
Aug 31, 2022 Vol.45 No.8, pp. 513~602
COVER PICTURE
Cryo-EM structure of human porphyrin transporter ABCB6 (main figure) shows that binding of hemin (inset, magenta) in concert with two glutathione molecules (cyan) primes ABCB6 for high ATP turnover (Kim et al., pp. 575-587).

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