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Mol. Cells 2010; 30(5): 383-391

Published online November 30, 2010

https://doi.org/10.1007/s10059-010-0157-1

© The Korean Society for Molecular and Cellular Biology

Bioactive Eicosanoids: Role of Prostaglandin F2α and F2-Isoprostanes in Inflammation and Oxidative Stress Related Pathology

Samar Basu*

Oxidative Stress and Inflammation, Department of Public Health and Caring Sciences, Faculty of Medicine, Uppsala University, Uppsala, Sweden, and Centre of Excellence-Inflammation, Uppsala University Hospital, Uppsala, Sweden

Correspondence to : *Correspondence: samar.basu@pubcare.uu.se

Received: October 2, 2010; Accepted: November 1, 2010

Abstract

Oxidative stress and inflammation are supposed to be the key players of several acute and chronic diseases, and also for progressive aging process. Eicosanoids, especially prostaglandin F (PGF) and F2-isoprostanes are endogenous compounds that are involved both in physiology and the above mentioned pathologies. These compounds are biosynthesized mainly from esterified arachidonic acid through both enzymatic and non-enzymatic free radical-catalysed reactions in vivo, respectively. They have shown to possess potent biological activities in addition to their application as biomarkers of oxidative stress and inflammation. Recent advancement of methodologies has made it possible to quantify these compounds more reliably and apply them in various in vivo studies successfully. Today, experimental and clinical studies have revealed that both PGF and F2-isoprostanes are involved in severe acute or chronic inflammatory conditions such as rheumatic diseases, asthma, risk factors of atherosclerosis, diabetes, ischemia-reperfusion, septic shock and many others. These evidences promote that assessment of bioactive PGF and F2-isoprostanes simultaneously in body fluids offers unique non-invasive analytical opportunity to study the function of these eicosanoids in physiology, oxidative stress-related and inflammatory diseases, and also in the determination of potency of various radical scavengers, anti-inflammatory compounds, drugs, antioxidants and diet.

Keywords eicosanoids, inflammation, isoprostanes, oxidative stress, prostaglandins

Article

Minireview

Mol. Cells 2010; 30(5): 383-391

Published online November 30, 2010 https://doi.org/10.1007/s10059-010-0157-1

Copyright © The Korean Society for Molecular and Cellular Biology.

Bioactive Eicosanoids: Role of Prostaglandin F2α and F2-Isoprostanes in Inflammation and Oxidative Stress Related Pathology

Samar Basu*

Oxidative Stress and Inflammation, Department of Public Health and Caring Sciences, Faculty of Medicine, Uppsala University, Uppsala, Sweden, and Centre of Excellence-Inflammation, Uppsala University Hospital, Uppsala, Sweden

Correspondence to:*Correspondence: samar.basu@pubcare.uu.se

Received: October 2, 2010; Accepted: November 1, 2010

Abstract

Oxidative stress and inflammation are supposed to be the key players of several acute and chronic diseases, and also for progressive aging process. Eicosanoids, especially prostaglandin F (PGF) and F2-isoprostanes are endogenous compounds that are involved both in physiology and the above mentioned pathologies. These compounds are biosynthesized mainly from esterified arachidonic acid through both enzymatic and non-enzymatic free radical-catalysed reactions in vivo, respectively. They have shown to possess potent biological activities in addition to their application as biomarkers of oxidative stress and inflammation. Recent advancement of methodologies has made it possible to quantify these compounds more reliably and apply them in various in vivo studies successfully. Today, experimental and clinical studies have revealed that both PGF and F2-isoprostanes are involved in severe acute or chronic inflammatory conditions such as rheumatic diseases, asthma, risk factors of atherosclerosis, diabetes, ischemia-reperfusion, septic shock and many others. These evidences promote that assessment of bioactive PGF and F2-isoprostanes simultaneously in body fluids offers unique non-invasive analytical opportunity to study the function of these eicosanoids in physiology, oxidative stress-related and inflammatory diseases, and also in the determination of potency of various radical scavengers, anti-inflammatory compounds, drugs, antioxidants and diet.

Keywords: eicosanoids, inflammation, isoprostanes, oxidative stress, prostaglandins

Mol. Cells
Aug 31, 2022 Vol.45 No.8, pp. 513~602
COVER PICTURE
Cryo-EM structure of human porphyrin transporter ABCB6 (main figure) shows that binding of hemin (inset, magenta) in concert with two glutathione molecules (cyan) primes ABCB6 for high ATP turnover (Kim et al., pp. 575-587).

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