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Mol. Cells 2008; 25(2): 242-246
Published online January 1, 1970
© The Korean Society for Molecular and Cellular Biology
Attenuated Neuropathic Pain in Ca(V)3.1 Null Mice
To assess the role of alpha(1G) T-type Ca2+ channels in neuropathic pain after L5 spinal nerve ligation, we examined behavioral pain susceptibility in mice lacking Ca(V)3.1 (a1G(-/-)), the gene encoding the pore-forming units of these channels. Reduced spontaneous pain responses and an increased threshold for paw withdrawal in response to mechanical stimulation were observed in these mice. The a1G(-/-) mice also showed attenuated thermal hyperalgesia in response to both low-(IR30) and high-intensity (IR60) infrared stimulation. Our results reveal the importance of alpha(1G) T-type Ca2+ channels in the development of neuropathic pain, and suggest that selective modulation of a1G subtype channels may provide a novel approach to the treatment of allodynia and hyperalgesia.
Keywords Central Sensitization, Hyperalgesia; Spinal Nerve Ligation (SNL), T-Type Calcium Channel, Allodynia
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Research Article
Mol. Cells 2008; 25(2): 242-246
Published online April 30, 2008
Copyright © The Korean Society for Molecular and Cellular Biology.
Attenuated Neuropathic Pain in Ca(V)3.1 Null Mice
Heung Sik Na, Soonwook Choi, Junesun Kim, Joonoh Park and Hee-Sup Shin
Abstract
To assess the role of alpha(1G) T-type Ca2+ channels in neuropathic pain after L5 spinal nerve ligation, we examined behavioral pain susceptibility in mice lacking Ca(V)3.1 (a1G(-/-)), the gene encoding the pore-forming units of these channels. Reduced spontaneous pain responses and an increased threshold for paw withdrawal in response to mechanical stimulation were observed in these mice. The a1G(-/-) mice also showed attenuated thermal hyperalgesia in response to both low-(IR30) and high-intensity (IR60) infrared stimulation. Our results reveal the importance of alpha(1G) T-type Ca2+ channels in the development of neuropathic pain, and suggest that selective modulation of a1G subtype channels may provide a novel approach to the treatment of allodynia and hyperalgesia.
Keywords: Central Sensitization, Hyperalgesia, Spinal Nerve Ligation (SNL), T-Type Calcium Channel, Allodynia
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