TOP

Minireview

Split Viewer

Mol. Cells 2010; 30(2): 93-98

Published online August 19, 2010

https://doi.org/10.1007/s10059-010-0133-9

© The Korean Society for Molecular and Cellular Biology

The Brain Microenvironment and Cancer Metastasis

Isaiah J. Fidler*, Krishnakumar Balasubramanian, Qingtang Lin, Seung Wook Kim, and Sun-Jin Kim

The University of Texas M. D. Anderson Cancer Center, Department of Cancer Biology, Cancer Metastasis Research Center, Houston, TX, USA

Correspondence to : *Correspondence: ifidler@mdanderson.org

Received: August 16, 2010; Accepted: August 19, 2010

Abstract

The process of metastasis consists of a series of sequential, selective steps that few cells can complete. The outcome of cancer metastasis depends on multiple interactions between metastatic cells and homeostatic mechanisms that are unique to one or another organ microenvironment. The specific organ microenvironment determines the extent of cancer cell proliferation, angiogenesis, invasion and survival. Many lung cancer, breast cancer, and melanoma patients develop fatal brain metastases that do not respond to therapy. The blood-brain barrier is intact in and around brain metastases that are smaller than 0.25 mm in diameter. Although the blood-brain barrier is leaky in larger metastases, the lesions are resistant to many chemotherapeutic drugs. Activated astrocytes surround and infiltrate brain metastases. The physiological role of astrocytes is to protect against neurotoxicity. Our current data demonstrate that activated astrocytes also protect tumor cells against chemotherapeutic drugs.

Keywords , brain metastasis, organ microenvironment, seed and soil hypothesis

Article

Minireview

Mol. Cells 2010; 30(2): 93-98

Published online August 31, 2010 https://doi.org/10.1007/s10059-010-0133-9

Copyright © The Korean Society for Molecular and Cellular Biology.

The Brain Microenvironment and Cancer Metastasis

Isaiah J. Fidler*, Krishnakumar Balasubramanian, Qingtang Lin, Seung Wook Kim, and Sun-Jin Kim

The University of Texas M. D. Anderson Cancer Center, Department of Cancer Biology, Cancer Metastasis Research Center, Houston, TX, USA

Correspondence to:*Correspondence: ifidler@mdanderson.org

Received: August 16, 2010; Accepted: August 19, 2010

Abstract

The process of metastasis consists of a series of sequential, selective steps that few cells can complete. The outcome of cancer metastasis depends on multiple interactions between metastatic cells and homeostatic mechanisms that are unique to one or another organ microenvironment. The specific organ microenvironment determines the extent of cancer cell proliferation, angiogenesis, invasion and survival. Many lung cancer, breast cancer, and melanoma patients develop fatal brain metastases that do not respond to therapy. The blood-brain barrier is intact in and around brain metastases that are smaller than 0.25 mm in diameter. Although the blood-brain barrier is leaky in larger metastases, the lesions are resistant to many chemotherapeutic drugs. Activated astrocytes surround and infiltrate brain metastases. The physiological role of astrocytes is to protect against neurotoxicity. Our current data demonstrate that activated astrocytes also protect tumor cells against chemotherapeutic drugs.

Keywords: , brain metastasis, organ microenvironment, seed and soil hypothesis

Mol. Cells
Nov 30, 2023 Vol.46 No.11, pp. 655~725
COVER PICTURE
Kim et al. (pp. 710-724) demonstrated that a pathogen-derived Ralstonia pseudosolanacearum type III effector RipL delays flowering time and enhances susceptibility to bacterial infection in Arabidopsis thaliana. Shown is the RipL-expressing Arabidopsis plant, which displays general dampening of the transcriptional program during pathogen infection, grown in long-day conditions.

Share this article on

  • line

Related articles in Mol. Cells

Molecules and Cells

eISSN 0219-1032
qr-code Download