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Mol. Cells 2010; 29(6): 581-584

Published online May 20, 2010

https://doi.org/10.1007/s10059-010-0072-5

© The Korean Society for Molecular and Cellular Biology

Anti-Candida Property of a Lignan Glycoside Derived from Styrax japonica S. et Z. via Membrane-Active Mechanisms

Cana Park, Eun-Rhan Woo1, and Dong Gun Lee*

Author Info. +

School of Life Sciences and Biotechnology, College of Natural Sciences, Kyungpook National University, Daegu 702-701, Korea, 1College of Pharmacy, Chosun University, Gwangju 501-759, Korea

Correspondence to : *Correspondence: dglee222@knu.ac.kr

Received: January 28, 2010; Revised: February 9, 2010; Accepted: February 10, 2010

Abstract

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Styraxjaponoside C was investigated with respect to its antifungal activity and mechanisms of action. Devoid of hemolytic activity, Styraxjaponoside C demonstrated an antifungal effect against the human pathogenic yeast Candida albicans in an energy-independent manner. To characterize the mechanisms of the antifungal activity of Styraxjaponoside C, fluorescence analysis with membrane probe 1,6-diphenyl-1,3,5-hexatriene, and flow cytometric analysis on C. albicans were conducted. The results showed that Styraxjaponosdie C induced cytoplasmic membrane perturbation. The current study suggested that Styraxjaponoside C was active against C. albicans with membrane-active mechanisms.

Keywords anti-candida property, membrane-active mechanism, Styraxjaponoside C

Article

Research Article

Mol. Cells 2010; 29(6): 581-584

Published online June 30, 2010 https://doi.org/10.1007/s10059-010-0072-5

Copyright © The Korean Society for Molecular and Cellular Biology.

Anti-Candida Property of a Lignan Glycoside Derived from Styrax japonica S. et Z. via Membrane-Active Mechanisms

Cana Park, Eun-Rhan Woo1, and Dong Gun Lee*

School of Life Sciences and Biotechnology, College of Natural Sciences, Kyungpook National University, Daegu 702-701, Korea, 1College of Pharmacy, Chosun University, Gwangju 501-759, Korea

Correspondence to:*Correspondence: dglee222@knu.ac.kr

Received: January 28, 2010; Revised: February 9, 2010; Accepted: February 10, 2010

Abstract

Styraxjaponoside C was investigated with respect to its antifungal activity and mechanisms of action. Devoid of hemolytic activity, Styraxjaponoside C demonstrated an antifungal effect against the human pathogenic yeast Candida albicans in an energy-independent manner. To characterize the mechanisms of the antifungal activity of Styraxjaponoside C, fluorescence analysis with membrane probe 1,6-diphenyl-1,3,5-hexatriene, and flow cytometric analysis on C. albicans were conducted. The results showed that Styraxjaponosdie C induced cytoplasmic membrane perturbation. The current study suggested that Styraxjaponoside C was active against C. albicans with membrane-active mechanisms.

Keywords: anti-candida property, membrane-active mechanism, Styraxjaponoside C

Mol. Cells
Sep 30, 2023 Vol.46 No.9, pp. 527~572
COVER PICTURE
Chronic obstructive pulmonary disease (COPD) is marked by airspace enlargement (emphysema) and small airway fibrosis, leading to airflow obstruction and eventual respiratory failure. Shown is a microphotograph of hematoxylin and eosin (H&E)-stained histological sections of the enlarged alveoli as an indicator of emphysema. Piao et al. (pp. 558-572) demonstrate that recombinant human hyaluronan and proteoglycan link protein 1 (rhHAPLN1) significantly reduces the extended airspaces of the emphysematous alveoli by increasing the levels of TGF-β receptor I and SIRT1/6, as a previously unrecognized mechanism in human alveolar epithelial cells, and consequently mitigates COPD.
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