Mol. Cells 2010; 29(5): 435-442
Published online April 12, 2010
https://doi.org/10.1007/s10059-010-0067-2
© The Korean Society for Molecular and Cellular Biology
Correspondence to : *Correspondence: agnieszka.loboda@uj.edu.pl (AL); jozef.dulak@uj.edu.pl (JD)
Hypoxia inducible factor (HIF)-1 and HIF-2 are heterodi-meric transcription factors mediating the cellular response to hypoxia. Recent data indicate that not only ubiquitous HIF-1α, but also more cell-specific HIF-2α, is an important regulator of the hypoxia response. Although both α subunits are highly conservative at protein level, share similar domain structure, heterodimerize with HIF-1β, and bind to the same DNA sequence called hypoxia responsive element (HRE), their effect on the expression of some genes may vary. In this review we stressed the differences between the isoforms, their structure and expression pattern. Moreover, we described diversity of coactivators and proteins which interact with HIFs, and which are responsible for the specificity of their action. Finally, recent data showing link between HIFs and specific microRNA have been presented.
Keywords c-myc, microRNA, Nrf2, prolyl hydroxylases, Ref-1
Mol. Cells 2010; 29(5): 435-442
Published online May 31, 2010 https://doi.org/10.1007/s10059-010-0067-2
Copyright © The Korean Society for Molecular and Cellular Biology.
Agnieszka Loboda*, Alicja Jozkowicz, and Jozef Dulak*
Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland
Correspondence to:*Correspondence: agnieszka.loboda@uj.edu.pl (AL); jozef.dulak@uj.edu.pl (JD)
Hypoxia inducible factor (HIF)-1 and HIF-2 are heterodi-meric transcription factors mediating the cellular response to hypoxia. Recent data indicate that not only ubiquitous HIF-1α, but also more cell-specific HIF-2α, is an important regulator of the hypoxia response. Although both α subunits are highly conservative at protein level, share similar domain structure, heterodimerize with HIF-1β, and bind to the same DNA sequence called hypoxia responsive element (HRE), their effect on the expression of some genes may vary. In this review we stressed the differences between the isoforms, their structure and expression pattern. Moreover, we described diversity of coactivators and proteins which interact with HIFs, and which are responsible for the specificity of their action. Finally, recent data showing link between HIFs and specific microRNA have been presented.
Keywords: c-myc, microRNA, Nrf2, prolyl hydroxylases, Ref-1
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