TOP
닫기
Search 닫기
Advanced Search Quick links
· Most Cited · Most Read · On-line First · Archives · Go to e-Submission

Research Article

Split Viewer

Mol. Cells 2010; 29(4): 355-361

Published online March 4, 2010

https://doi.org/10.1007/s10059-010-0038-7

© The Korean Society for Molecular and Cellular Biology

Identification and Characterization of CMTM4, a Novel Gene with Inhibitory Effects on HeLa Cell Growth through Inducing G2/M Phase Accumulation

Markus Plate, Ting Li, Yu Wang, Xiaoning Mo, Yingmei Zhang, Dalong Ma, and Wenling Han*

Author Info. +

Center for Human Disease Genomics, Department of Immunology, School of Basic Medical Science, Health Science Center, Peking University, Beijing 100191, China

Correspondence to : *Correspondence: hanwl@bjmu.edu.cn

Received: September 15, 2009; Revised: December 6, 2009; Accepted: December 7, 2009

Abstract

Go to

Human CMTM is a novel gene family consisting of CKLF and CMTM1-8. CMTM4 is the most conserved gene and has three RNA splicing forms designated as CMTM4-v1, -v2 and -v3, but in many types of tissue and cell lines, only CMTM4-v1 and -v2 could be detected. CMTM4-v2 is the full length cDNA product, which has been highly conserved during evolution. CMTM4-v1 and -v2 are broadly expressed in normal types of tissue. They are distributed on the cell membrane and across the cytoplasm in a speckled pattern. Overexpression of CMTM4-v1 and -v2 can inhibit HeLa cell growth via G2/M phase accumulation without inducing apoptosis. Therefore, CMTM4 might be an important gene involved in cell growth and cell cycle regulation.

Keywords apoptosis, cell cycle, cell growth, CMTM4, MARVEL

Article

Research Article

Mol. Cells 2010; 29(4): 355-361

Published online March 4, 2010 https://doi.org/10.1007/s10059-010-0038-7

Copyright © The Korean Society for Molecular and Cellular Biology.

Identification and Characterization of CMTM4, a Novel Gene with Inhibitory Effects on HeLa Cell Growth through Inducing G2/M Phase Accumulation

Markus Plate, Ting Li, Yu Wang, Xiaoning Mo, Yingmei Zhang, Dalong Ma, and Wenling Han*

Center for Human Disease Genomics, Department of Immunology, School of Basic Medical Science, Health Science Center, Peking University, Beijing 100191, China

Correspondence to:*Correspondence: hanwl@bjmu.edu.cn

Received: September 15, 2009; Revised: December 6, 2009; Accepted: December 7, 2009

Abstract

Human CMTM is a novel gene family consisting of CKLF and CMTM1-8. CMTM4 is the most conserved gene and has three RNA splicing forms designated as CMTM4-v1, -v2 and -v3, but in many types of tissue and cell lines, only CMTM4-v1 and -v2 could be detected. CMTM4-v2 is the full length cDNA product, which has been highly conserved during evolution. CMTM4-v1 and -v2 are broadly expressed in normal types of tissue. They are distributed on the cell membrane and across the cytoplasm in a speckled pattern. Overexpression of CMTM4-v1 and -v2 can inhibit HeLa cell growth via G2/M phase accumulation without inducing apoptosis. Therefore, CMTM4 might be an important gene involved in cell growth and cell cycle regulation.

Keywords: apoptosis, cell cycle, cell growth, CMTM4, MARVEL

Mol. Cells
May 31, 2023 Vol.46 No.5, pp. 259~328
COVER PICTURE
The alpha-helices in the lamin filaments are depicted as coils, with different subdomains distinguished by various colors. Coil 1a is represented by magenta, coil 1b by yellow, L2 by green, coil 2a by white, coil 2b by brown, stutter by cyan, coil 2c by dark blue, and the lamin Ig-like domain by grey. In the background, cells are displayed, with the cytosol depicted in green and the nucleus in blue (Ahn et al., pp. 309-318).
Current Issue Archives

Share this article on

  • line
  • mail

Related articles in Mol. Cells

Molecules and Cells

eISSN 0219-1032
qr-code Download