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Mol. Cells 2010; 29(4): 355-361

Published online March 4, 2010

https://doi.org/10.1007/s10059-010-0038-7

© The Korean Society for Molecular and Cellular Biology

Identification and Characterization of CMTM4, a Novel Gene with Inhibitory Effects on HeLa Cell Growth through Inducing G2/M Phase Accumulation

Markus Plate, Ting Li, Yu Wang, Xiaoning Mo, Yingmei Zhang, Dalong Ma, and Wenling Han*

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Center for Human Disease Genomics, Department of Immunology, School of Basic Medical Science, Health Science Center, Peking University, Beijing 100191, China

Correspondence to : *Correspondence: hanwl@bjmu.edu.cn

Received: September 15, 2009; Revised: December 6, 2009; Accepted: December 7, 2009

Abstract

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Human CMTM is a novel gene family consisting of CKLF and CMTM1-8. CMTM4 is the most conserved gene and has three RNA splicing forms designated as CMTM4-v1, -v2 and -v3, but in many types of tissue and cell lines, only CMTM4-v1 and -v2 could be detected. CMTM4-v2 is the full length cDNA product, which has been highly conserved during evolution. CMTM4-v1 and -v2 are broadly expressed in normal types of tissue. They are distributed on the cell membrane and across the cytoplasm in a speckled pattern. Overexpression of CMTM4-v1 and -v2 can inhibit HeLa cell growth via G2/M phase accumulation without inducing apoptosis. Therefore, CMTM4 might be an important gene involved in cell growth and cell cycle regulation.

Keywords apoptosis, cell cycle, cell growth, CMTM4, MARVEL

Article

Research Article

Mol. Cells 2010; 29(4): 355-361

Published online March 4, 2010 https://doi.org/10.1007/s10059-010-0038-7

Copyright © The Korean Society for Molecular and Cellular Biology.

Identification and Characterization of CMTM4, a Novel Gene with Inhibitory Effects on HeLa Cell Growth through Inducing G2/M Phase Accumulation

Markus Plate, Ting Li, Yu Wang, Xiaoning Mo, Yingmei Zhang, Dalong Ma, and Wenling Han*

Center for Human Disease Genomics, Department of Immunology, School of Basic Medical Science, Health Science Center, Peking University, Beijing 100191, China

Correspondence to:*Correspondence: hanwl@bjmu.edu.cn

Received: September 15, 2009; Revised: December 6, 2009; Accepted: December 7, 2009

Abstract

Human CMTM is a novel gene family consisting of CKLF and CMTM1-8. CMTM4 is the most conserved gene and has three RNA splicing forms designated as CMTM4-v1, -v2 and -v3, but in many types of tissue and cell lines, only CMTM4-v1 and -v2 could be detected. CMTM4-v2 is the full length cDNA product, which has been highly conserved during evolution. CMTM4-v1 and -v2 are broadly expressed in normal types of tissue. They are distributed on the cell membrane and across the cytoplasm in a speckled pattern. Overexpression of CMTM4-v1 and -v2 can inhibit HeLa cell growth via G2/M phase accumulation without inducing apoptosis. Therefore, CMTM4 might be an important gene involved in cell growth and cell cycle regulation.

Keywords: apoptosis, cell cycle, cell growth, CMTM4, MARVEL

Mol. Cells
Sep 30, 2023 Vol.46 No.9, pp. 527~572
COVER PICTURE
Chronic obstructive pulmonary disease (COPD) is marked by airspace enlargement (emphysema) and small airway fibrosis, leading to airflow obstruction and eventual respiratory failure. Shown is a microphotograph of hematoxylin and eosin (H&E)-stained histological sections of the enlarged alveoli as an indicator of emphysema. Piao et al. (pp. 558-572) demonstrate that recombinant human hyaluronan and proteoglycan link protein 1 (rhHAPLN1) significantly reduces the extended airspaces of the emphysematous alveoli by increasing the levels of TGF-β receptor I and SIRT1/6, as a previously unrecognized mechanism in human alveolar epithelial cells, and consequently mitigates COPD.
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