Mol. Cells 2010; 29(4): 355-361
Published online March 4, 2010
https://doi.org/10.1007/s10059-010-0038-7
© The Korean Society for Molecular and Cellular Biology
Correspondence to : *Correspondence: hanwl@bjmu.edu.cn
Human CMTM is a novel gene family consisting of CKLF and CMTM1-8. CMTM4 is the most conserved gene and has three RNA splicing forms designated as CMTM4-v1, -v2 and -v3, but in many types of tissue and cell lines, only CMTM4-v1 and -v2 could be detected. CMTM4-v2 is the full length cDNA product, which has been highly conserved during evolution. CMTM4-v1 and -v2 are broadly expressed in normal types of tissue. They are distributed on the cell membrane and across the cytoplasm in a speckled pattern. Overexpression of CMTM4-v1 and -v2 can inhibit HeLa cell growth via G2/M phase accumulation without inducing apoptosis. Therefore, CMTM4 might be an important gene involved in cell growth and cell cycle regulation.
Keywords apoptosis, cell cycle, cell growth, CMTM4, MARVEL
Mol. Cells 2010; 29(4): 355-361
Published online March 4, 2010 https://doi.org/10.1007/s10059-010-0038-7
Copyright © The Korean Society for Molecular and Cellular Biology.
Markus Plate, Ting Li, Yu Wang, Xiaoning Mo, Yingmei Zhang, Dalong Ma, and Wenling Han*
Center for Human Disease Genomics, Department of Immunology, School of Basic Medical Science, Health Science Center, Peking University, Beijing 100191, China
Correspondence to:*Correspondence: hanwl@bjmu.edu.cn
Human CMTM is a novel gene family consisting of CKLF and CMTM1-8. CMTM4 is the most conserved gene and has three RNA splicing forms designated as CMTM4-v1, -v2 and -v3, but in many types of tissue and cell lines, only CMTM4-v1 and -v2 could be detected. CMTM4-v2 is the full length cDNA product, which has been highly conserved during evolution. CMTM4-v1 and -v2 are broadly expressed in normal types of tissue. They are distributed on the cell membrane and across the cytoplasm in a speckled pattern. Overexpression of CMTM4-v1 and -v2 can inhibit HeLa cell growth via G2/M phase accumulation without inducing apoptosis. Therefore, CMTM4 might be an important gene involved in cell growth and cell cycle regulation.
Keywords: apoptosis, cell cycle, cell growth, CMTM4, MARVEL
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