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Mol. Cells 2010; 29(4): 349-354

Published online March 4, 2010

https://doi.org/10.1007/s10059-010-0044-9

© The Korean Society for Molecular and Cellular Biology

Amelioration of Streptozotocin-Induced Diabetes by Agrocybe chaxingu Polysaccharide

Byung Ryong Lee, Yeom Pyo Lee, Dae Won Kim, Ha Yong Song, Ki-Yeon Yoo1, Moo Ho Won1,
Tae-Cheon Kang1, Kwang Jae Lee2, Kyung Hee Kim2, Jin Ho Joo3, Hun Ju Ham3, Jang Hyun Hur3,
Sung-Woo Cho4, Kyu Hyung Han, Kil Soo Lee, Jinseu Park, Won Sik Eum*, and Soo Young Choi*

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Department of Biomedical Science and Research Institute for Bioscience and Biotechnology, Hallym University, Chunchon 200-702, Korea, 1Department of Anatomy and Neurobiology, College of Medicine, Hallym University, Chuncheon 200-702, Korea, 2Gangwon Agricultural Research and Extention Services, Chuncheon 200-182, Korea, 3Department of Biological Environment, Kangwon National University, Chuncheon 200-710, Korea, 4Department of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, Seoul 138-736, Korea

Correspondence to : *Correspondence: sychoi@hallym.ac.kr

Received: September 14, 2010; Revised: December 27, 2010; Accepted: January 4, 2010

Abstract

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The aim of this study was to investigate the preventive effect of Agrocybe chaxingu polysaccharide on streptozocin (STZ)-induced pancreatic β-cells destruction. Agrocybe chaxingu polysaccharide markedly reduced nitric oxide (NO) production and iNOS expression levels in RINm5F cells in a dose-dependent manner. In addition, Agrocybe chaxingu polysaccharide significantly inhibited iNOS expression and blood glucose levels in STZ-induced diabetic mice. Moreover, immunohistochemical analysis revealed that it enhanced pancreatic β-cells resistance to destruction by STZ. These results suggest that Agrocybe chaxingu polysaccharide may have value as a therapeutic agent against diabetes mellitus.

Keywords Agrocybe chaxingu, blood glucose, nitric oxide (NO), polysaccharide

Article

Research Article

Mol. Cells 2010; 29(4): 349-354

Published online March 4, 2010 https://doi.org/10.1007/s10059-010-0044-9

Copyright © The Korean Society for Molecular and Cellular Biology.

Amelioration of Streptozotocin-Induced Diabetes by Agrocybe chaxingu Polysaccharide

Byung Ryong Lee, Yeom Pyo Lee, Dae Won Kim, Ha Yong Song, Ki-Yeon Yoo1, Moo Ho Won1,
Tae-Cheon Kang1, Kwang Jae Lee2, Kyung Hee Kim2, Jin Ho Joo3, Hun Ju Ham3, Jang Hyun Hur3,
Sung-Woo Cho4, Kyu Hyung Han, Kil Soo Lee, Jinseu Park, Won Sik Eum*, and Soo Young Choi*

Department of Biomedical Science and Research Institute for Bioscience and Biotechnology, Hallym University, Chunchon 200-702, Korea, 1Department of Anatomy and Neurobiology, College of Medicine, Hallym University, Chuncheon 200-702, Korea, 2Gangwon Agricultural Research and Extention Services, Chuncheon 200-182, Korea, 3Department of Biological Environment, Kangwon National University, Chuncheon 200-710, Korea, 4Department of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, Seoul 138-736, Korea

Correspondence to:*Correspondence: sychoi@hallym.ac.kr

Received: September 14, 2010; Revised: December 27, 2010; Accepted: January 4, 2010

Abstract

The aim of this study was to investigate the preventive effect of Agrocybe chaxingu polysaccharide on streptozocin (STZ)-induced pancreatic β-cells destruction. Agrocybe chaxingu polysaccharide markedly reduced nitric oxide (NO) production and iNOS expression levels in RINm5F cells in a dose-dependent manner. In addition, Agrocybe chaxingu polysaccharide significantly inhibited iNOS expression and blood glucose levels in STZ-induced diabetic mice. Moreover, immunohistochemical analysis revealed that it enhanced pancreatic β-cells resistance to destruction by STZ. These results suggest that Agrocybe chaxingu polysaccharide may have value as a therapeutic agent against diabetes mellitus.

Keywords: Agrocybe chaxingu, blood glucose, nitric oxide (NO), polysaccharide

Mol. Cells
Nov 30, 2023 Vol.46 No.11, pp. 655~725
COVER PICTURE
Kim et al. (pp. 710-724) demonstrated that a pathogen-derived Ralstonia pseudosolanacearum type III effector RipL delays flowering time and enhances susceptibility to bacterial infection in Arabidopsis thaliana. Shown is the RipL-expressing Arabidopsis plant, which displays general dampening of the transcriptional program during pathogen infection, grown in long-day conditions.
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