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Mol. Cells 2010; 29(1): 1-7

Published online January 31, 2010

https://doi.org/10.1007/s10059-010-0014-2

© The Korean Society for Molecular and Cellular Biology

Autophagy in Viral Replication and Pathogenesis Considerations and Structural Conservation

Donna Sir, and Jing-hsiung James Ou*

Department of Molecular Microbiology and Immunology, University of Southern California, Keck School of Medicine, Los Angeles, California 90033, USA

Correspondence to : *Correspondence: jamesou@hsc.usc.edu

Received: November 30, 2009; Accepted: December 2, 2009

Abstract

Autophagy is a catabolic process that is important for the removal of damaged organelles and long-lived pro-teins for the maintenance of cellular homeostasis. It can also serve as innate immunity to remove intracellular microbial pa-thogens. A growing list of viruses has been shown to affect this cellular pathway. Some viruses suppress this pathway for their survival, while others enhance or exploit this pathway to benefit their replication. The effect of viruses on autophagy may also sensitize cells to death or enhance cell survival and play a critical role in viral pathogenesis. In this article, we review the relationships between different viruses and autophagy and discuss how these relationships may affect viruses and their host cells.

Keywords autophagic vacuoles, autophagosomes, autophagy, viral infections, viral pathogenesis, viral replication

Article

Minireview

Mol. Cells 2010; 29(1): 1-7

Published online January 31, 2010 https://doi.org/10.1007/s10059-010-0014-2

Copyright © The Korean Society for Molecular and Cellular Biology.

Autophagy in Viral Replication and Pathogenesis Considerations and Structural Conservation

Donna Sir, and Jing-hsiung James Ou*

Department of Molecular Microbiology and Immunology, University of Southern California, Keck School of Medicine, Los Angeles, California 90033, USA

Correspondence to:*Correspondence: jamesou@hsc.usc.edu

Received: November 30, 2009; Accepted: December 2, 2009

Abstract

Autophagy is a catabolic process that is important for the removal of damaged organelles and long-lived pro-teins for the maintenance of cellular homeostasis. It can also serve as innate immunity to remove intracellular microbial pa-thogens. A growing list of viruses has been shown to affect this cellular pathway. Some viruses suppress this pathway for their survival, while others enhance or exploit this pathway to benefit their replication. The effect of viruses on autophagy may also sensitize cells to death or enhance cell survival and play a critical role in viral pathogenesis. In this article, we review the relationships between different viruses and autophagy and discuss how these relationships may affect viruses and their host cells.

Keywords: autophagic vacuoles, autophagosomes, autophagy, viral infections, viral pathogenesis, viral replication

Mol. Cells
May 31, 2022 Vol.45 No.5, pp. 273~352
COVER PICTURE
Fe2+ ion depletion-induced expression of BΔGFP at the early stage of leaf development (Choi et al., pp. 294-305).

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