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Mol. Cells 2010; 29(1): 1-7

Published online January 8, 2010

https://doi.org/10.1007/s10059-010-0014-2

© The Korean Society for Molecular and Cellular Biology

Autophagy in Viral Replication and Pathogenesis Considerations and Structural Conservation

Donna Sir, and Jing-hsiung James Ou*

Department of Molecular Microbiology and Immunology, University of Southern California, Keck School of Medicine, Los Angeles, California 90033, USA

Correspondence to : *Correspondence: jamesou@hsc.usc.edu

Received: November 30, 2009; Accepted: December 2, 2009

Abstract

Autophagy is a catabolic process that is important for the removal of damaged organelles and long-lived pro-teins for the maintenance of cellular homeostasis. It can also serve as innate immunity to remove intracellular microbial pa-thogens. A growing list of viruses has been shown to affect this cellular pathway. Some viruses suppress this pathway for their survival, while others enhance or exploit this pathway to benefit their replication. The effect of viruses on autophagy may also sensitize cells to death or enhance cell survival and play a critical role in viral pathogenesis. In this article, we review the relationships between different viruses and autophagy and discuss how these relationships may affect viruses and their host cells.

Keywords autophagic vacuoles, autophagosomes, autophagy, viral infections, viral pathogenesis, viral replication

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Mol. Cells 2010; 29(1): 1-7

Published online January 31, 2010 https://doi.org/10.1007/s10059-010-0014-2

Copyright © The Korean Society for Molecular and Cellular Biology.

Autophagy in Viral Replication and Pathogenesis Considerations and Structural Conservation

Donna Sir, and Jing-hsiung James Ou*

Department of Molecular Microbiology and Immunology, University of Southern California, Keck School of Medicine, Los Angeles, California 90033, USA

Correspondence to:*Correspondence: jamesou@hsc.usc.edu

Received: November 30, 2009; Accepted: December 2, 2009

Abstract

Autophagy is a catabolic process that is important for the removal of damaged organelles and long-lived pro-teins for the maintenance of cellular homeostasis. It can also serve as innate immunity to remove intracellular microbial pa-thogens. A growing list of viruses has been shown to affect this cellular pathway. Some viruses suppress this pathway for their survival, while others enhance or exploit this pathway to benefit their replication. The effect of viruses on autophagy may also sensitize cells to death or enhance cell survival and play a critical role in viral pathogenesis. In this article, we review the relationships between different viruses and autophagy and discuss how these relationships may affect viruses and their host cells.

Keywords: autophagic vacuoles, autophagosomes, autophagy, viral infections, viral pathogenesis, viral replication

Mol. Cells
Nov 30, 2023 Vol.46 No.11, pp. 655~725
COVER PICTURE
Kim et al. (pp. 710-724) demonstrated that a pathogen-derived Ralstonia pseudosolanacearum type III effector RipL delays flowering time and enhances susceptibility to bacterial infection in Arabidopsis thaliana. Shown is the RipL-expressing Arabidopsis plant, which displays general dampening of the transcriptional program during pathogen infection, grown in long-day conditions.

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