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Mol. Cells 2009; 28(6): 583-588

Published online December 31, 2009

https://doi.org/10.1007/s10059-009-0152-6

© The Korean Society for Molecular and Cellular Biology

Peroxiredoxin 6 Promotes Lung Cancer Cell
Invasion by Inducing Urokinase-Type Plasmi-nogen
Activator via p38 Kinase, Phosphoinositide
3-Kinase, and Akt

Seung Bum Lee, Jin-Nyoung Ho, Sung Hwan Yoon, Ga Young Kang, Sang-Gu Hwang, and
Hong-Duck Um

Received: September 9, 2009; Accepted: September 17, 2009

Abstract

The peroxiredoxin family of peroxidase has six mammalian members (Prx 1-6). Considering their frequent up-regulation in cancer cells, Prxs may contribute to cancer cells’ survival in face of oxidative stress. Here, we show that Prx 6 promotes the invasiveness of lung cancer cells, accompanied by an increase in the activity of phosphoinositide 3-kinase (PI3K), the phosphorylation of p38 kinase and Akt, and the protein levels of uPA. Functional studies reveal that these components support Prx 6-induced invasion in the sequence p38 kinase/PI3K, Akt, and uPA. The findings provide a new understanding of the action of Prx 6 in cancer.

Keywords cancer, cell signaling, invasion, peroxiredoxin 6

Article

Research Article

Mol. Cells 2009; 28(6): 583-588

Published online December 31, 2009 https://doi.org/10.1007/s10059-009-0152-6

Copyright © The Korean Society for Molecular and Cellular Biology.

Peroxiredoxin 6 Promotes Lung Cancer Cell
Invasion by Inducing Urokinase-Type Plasmi-nogen
Activator via p38 Kinase, Phosphoinositide
3-Kinase, and Akt

Seung Bum Lee, Jin-Nyoung Ho, Sung Hwan Yoon, Ga Young Kang, Sang-Gu Hwang, and
Hong-Duck Um

Received: September 9, 2009; Accepted: September 17, 2009

Abstract

The peroxiredoxin family of peroxidase has six mammalian members (Prx 1-6). Considering their frequent up-regulation in cancer cells, Prxs may contribute to cancer cells’ survival in face of oxidative stress. Here, we show that Prx 6 promotes the invasiveness of lung cancer cells, accompanied by an increase in the activity of phosphoinositide 3-kinase (PI3K), the phosphorylation of p38 kinase and Akt, and the protein levels of uPA. Functional studies reveal that these components support Prx 6-induced invasion in the sequence p38 kinase/PI3K, Akt, and uPA. The findings provide a new understanding of the action of Prx 6 in cancer.

Keywords: cancer, cell signaling, invasion, peroxiredoxin 6

Mol. Cells
Nov 30, 2022 Vol.45 No.11, pp. 763~867
COVER PICTURE
Naive (cyan) and axotomized (magenta) retinal ganglion cell axons in Xenopus tropicalis (Choi et al., pp. 846-854).

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