Mol. Cells 2009; 28(6): 583-588
Published online November 19, 2009
https://doi.org/10.1007/s10059-009-0152-6
© The Korean Society for Molecular and Cellular Biology
The peroxiredoxin family of peroxidase has six mammalian members (Prx 1-6). Considering their frequent up-regulation in cancer cells, Prxs may contribute to cancer cells’ survival in face of oxidative stress. Here, we show that Prx 6 promotes the invasiveness of lung cancer cells, accompanied by an increase in the activity of phosphoinositide 3-kinase (PI3K), the phosphorylation of p38 kinase and Akt, and the protein levels of uPA. Functional studies reveal that these components support Prx 6-induced invasion in the sequence p38 kinase/PI3K, Akt, and uPA. The findings provide a new understanding of the action of Prx 6 in cancer.
Keywords cancer, cell signaling, invasion, peroxiredoxin 6
Mol. Cells 2009; 28(6): 583-588
Published online December 31, 2009 https://doi.org/10.1007/s10059-009-0152-6
Copyright © The Korean Society for Molecular and Cellular Biology.
Seung Bum Lee, Jin-Nyoung Ho, Sung Hwan Yoon, Ga Young Kang, Sang-Gu Hwang, and
Hong-Duck Um
The peroxiredoxin family of peroxidase has six mammalian members (Prx 1-6). Considering their frequent up-regulation in cancer cells, Prxs may contribute to cancer cells’ survival in face of oxidative stress. Here, we show that Prx 6 promotes the invasiveness of lung cancer cells, accompanied by an increase in the activity of phosphoinositide 3-kinase (PI3K), the phosphorylation of p38 kinase and Akt, and the protein levels of uPA. Functional studies reveal that these components support Prx 6-induced invasion in the sequence p38 kinase/PI3K, Akt, and uPA. The findings provide a new understanding of the action of Prx 6 in cancer.
Keywords: cancer, cell signaling, invasion, peroxiredoxin 6
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