Mol. Cells 2009; 28(4): 365-368
Published online September 30, 2009
https://doi.org/10.1007/s10059-009-0130-z
© The Korean Society for Molecular and Cellular Biology
Toll-like receptors (TLRs) play an important role in host defense by sensing invading microbial pathogens and initiating innate immune responses. The stimulation of TLRs by microbial components triggers the activation of myeloid differential factor 88 (MyD88)- and toll-interleukin-1 receptor domain-containing adapter inducing interferon-ß(TRIF)-dependent downstream signaling pathways. Isoliquiritigenin (ILG), an active ingredient of Licorice, has been used for centuries to treat many chronic diseases. ILG inhibits the MyD88-dependent pathway by inhibiting the activity of inhibitor-κB kinase. However, it is not known whether ILG inhibits the TRIF-dependent pathway. To evaluate the therapeutic potential of ILG, we examined its effect on signal transduction via the TRIF-dependent pathway of TLRs induced by several agonists. ILG inhibited nuclear factor-κB and interferon regulatory factor 3 activation induced by lipopolysaccharide or polyinosinic-polycytidylic acid. ILG inhibited the lipopolysaccharide-induced phos-phorylation of interferon regulatory factor 3 as well as interferon-inducible genes such as interferon inducible protein-10, and regulated activation of normal T-cell ex-pressed and secreted (RANTES). These results suggest that ILG can modulate TRIF-dependent signaling pathways of TLRs, leading to decreased inflammatory gene expression.
Keywords adhesion, Lad, migration, SH2 domain, TSAd
Mol. Cells 2009; 28(4): 365-368
Published online October 31, 2009 https://doi.org/10.1007/s10059-009-0130-z
Copyright © The Korean Society for Molecular and Cellular Biology.
Se-Jeong Park, Ho-Yeon Song, and Hyung-Sun Youn
Toll-like receptors (TLRs) play an important role in host defense by sensing invading microbial pathogens and initiating innate immune responses. The stimulation of TLRs by microbial components triggers the activation of myeloid differential factor 88 (MyD88)- and toll-interleukin-1 receptor domain-containing adapter inducing interferon-ß(TRIF)-dependent downstream signaling pathways. Isoliquiritigenin (ILG), an active ingredient of Licorice, has been used for centuries to treat many chronic diseases. ILG inhibits the MyD88-dependent pathway by inhibiting the activity of inhibitor-κB kinase. However, it is not known whether ILG inhibits the TRIF-dependent pathway. To evaluate the therapeutic potential of ILG, we examined its effect on signal transduction via the TRIF-dependent pathway of TLRs induced by several agonists. ILG inhibited nuclear factor-κB and interferon regulatory factor 3 activation induced by lipopolysaccharide or polyinosinic-polycytidylic acid. ILG inhibited the lipopolysaccharide-induced phos-phorylation of interferon regulatory factor 3 as well as interferon-inducible genes such as interferon inducible protein-10, and regulated activation of normal T-cell ex-pressed and secreted (RANTES). These results suggest that ILG can modulate TRIF-dependent signaling pathways of TLRs, leading to decreased inflammatory gene expression.
Keywords: adhesion, Lad, migration, SH2 domain, TSAd
Youngbong Choi, Eunkyung Park, Eunseon Ahn, Inyoung Park, and Yungdae Yun
Mol. Cells 2009; 28(3): 183-188 https://doi.org/10.1007/s10059-009-0121-0Inyoung Park, Myoungsun Son, Eunseon Ahn, Young-Woong Kim, Young-Yun Kong, and Yungdae Yun
Mol. Cells 2020; 43(11): 921-934 https://doi.org/10.14348/molcells.2020.0124JiSheng Hu, ShangJing Pi, MingRui Xiong, ZhongYing Liu, Xia Huang, Ran An, TongCun Zhang, and BaiYin Yuan
Mol. Cells 2020; 43(8): 749-762 https://doi.org/10.14348/molcells.2020.0085