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Mol. Cells 2009; 28(4): 315-320

Published online September 30, 2009

https://doi.org/10.1007/s10059-009-0143-7

© The Korean Society for Molecular and Cellular Biology

Non-Redundancy within the RAS Oncogene Family: Insights into Mutational Disparities inCancer

Ken S. Lau, and Kevin M. Haigis

Received: September 8, 2009; Accepted: September 11, 2009

Abstract

The RAS family of oncoproteins has been studied exten-sively for almost three decades. While we know that activation of RAS represents a key feature of malignant transformation for many cancers, we are only now beginning to understand the complex underpinnings of RAS biology. Here, we will discuss emerging cancer genome sequencing data in the context of what is currently known about RAS function. Taken together, retrospective studies of primary human tissues and prospective studies of experimental models support the notion that the variable mutation frequencies exhibited by the RAS oncogenes reflect unique functions of the RAS oncoproteins.

Keywords cancer, mutation, RAS, signaling

Article

Minireview

Mol. Cells 2009; 28(4): 315-320

Published online October 31, 2009 https://doi.org/10.1007/s10059-009-0143-7

Copyright © The Korean Society for Molecular and Cellular Biology.

Non-Redundancy within the RAS Oncogene Family: Insights into Mutational Disparities inCancer

Ken S. Lau, and Kevin M. Haigis

Received: September 8, 2009; Accepted: September 11, 2009

Abstract

The RAS family of oncoproteins has been studied exten-sively for almost three decades. While we know that activation of RAS represents a key feature of malignant transformation for many cancers, we are only now beginning to understand the complex underpinnings of RAS biology. Here, we will discuss emerging cancer genome sequencing data in the context of what is currently known about RAS function. Taken together, retrospective studies of primary human tissues and prospective studies of experimental models support the notion that the variable mutation frequencies exhibited by the RAS oncogenes reflect unique functions of the RAS oncoproteins.

Keywords: cancer, mutation, RAS, signaling

Mol. Cells
Feb 28, 2023 Vol.46 No.2, pp. 69~129
COVER PICTURE
The bulk tissue is a heterogeneous mixture of various cell types, which is depicted as a skein of intertwined threads with diverse colors each of which represents a unique cell type. Single-cell omics analysis untangles efficiently the skein according to the color by providing information of molecules at individual cells and interpretation of such information based on different cell types. The molecules that can be profiled at the individual cell by single-cell omics analysis includes DNA (bottom middle), RNA (bottom right), and protein (bottom left). This special issue reviews single-cell technologies and computational methods that have been developed for the single-cell omics analysis and how they have been applied to improve our understanding of the underlying mechanisms of biological and pathological phenomena at the single-cell level.

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Molecules and Cells

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