Mol. Cells 2009; 28(4): 315-320
Published online September 30, 2009
https://doi.org/10.1007/s10059-009-0143-7
© The Korean Society for Molecular and Cellular Biology
The RAS family of oncoproteins has been studied exten-sively for almost three decades. While we know that activation of RAS represents a key feature of malignant transformation for many cancers, we are only now beginning to understand the complex underpinnings of RAS biology. Here, we will discuss emerging cancer genome sequencing data in the context of what is currently known about RAS function. Taken together, retrospective studies of primary human tissues and prospective studies of experimental models support the notion that the variable mutation frequencies exhibited by the RAS oncogenes reflect unique functions of the RAS oncoproteins.
Keywords cancer, mutation, RAS, signaling
Mol. Cells 2009; 28(4): 315-320
Published online October 31, 2009 https://doi.org/10.1007/s10059-009-0143-7
Copyright © The Korean Society for Molecular and Cellular Biology.
Ken S. Lau, and Kevin M. Haigis
The RAS family of oncoproteins has been studied exten-sively for almost three decades. While we know that activation of RAS represents a key feature of malignant transformation for many cancers, we are only now beginning to understand the complex underpinnings of RAS biology. Here, we will discuss emerging cancer genome sequencing data in the context of what is currently known about RAS function. Taken together, retrospective studies of primary human tissues and prospective studies of experimental models support the notion that the variable mutation frequencies exhibited by the RAS oncogenes reflect unique functions of the RAS oncoproteins.
Keywords: cancer, mutation, RAS, signaling
Youjin Na, Gang Huang, and Jianqiang Wu
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