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Mol. Cells 2009; 28(3): 149-154

Published online September 30, 2009

https://doi.org/10.1007/s10059-009-0127-7

© The Korean Society for Molecular and Cellular Biology

Histone Modifications During DNA Replication

Karina B. Falbo, and Xuetong Shen

Received: August 31, 2009; Accepted: September 2, 2009

Abstract

Faithful and accurate replication of the DNA molecule is essential for eukaryote organisms. Nonetheless, in the last few years it has become evident that inheritance of the chromatin states associated with different regions of the genome is as important as the faithful inheritance of the DNA sequence itself. Such chromatin states are determined by a multitude of factors that act to modify not only the DNA molecule, but also the histone proteins associated with it. For instance, histones can be posttranslationally modified, and it is well established that these posttranslational marks are involved in several essential nuclear processes such as transcription and DNA repair. However, recent evidence indicates that posttranslational modifications of histones might be relevant during DNA replication. Hence, the aim of this review is to describe the most recent publications related to the role of histone posttranslational modifications during DNA replication.

Keywords acetylation, chromatin remodeling, DNA replication, histone, methylation, phosphorylation, post translational modification, ubiquitination

Article

Minireview

Mol. Cells 2009; 28(3): 149-154

Published online September 30, 2009 https://doi.org/10.1007/s10059-009-0127-7

Copyright © The Korean Society for Molecular and Cellular Biology.

Histone Modifications During DNA Replication

Karina B. Falbo, and Xuetong Shen

Received: August 31, 2009; Accepted: September 2, 2009

Abstract

Faithful and accurate replication of the DNA molecule is essential for eukaryote organisms. Nonetheless, in the last few years it has become evident that inheritance of the chromatin states associated with different regions of the genome is as important as the faithful inheritance of the DNA sequence itself. Such chromatin states are determined by a multitude of factors that act to modify not only the DNA molecule, but also the histone proteins associated with it. For instance, histones can be posttranslationally modified, and it is well established that these posttranslational marks are involved in several essential nuclear processes such as transcription and DNA repair. However, recent evidence indicates that posttranslational modifications of histones might be relevant during DNA replication. Hence, the aim of this review is to describe the most recent publications related to the role of histone posttranslational modifications during DNA replication.

Keywords: acetylation, chromatin remodeling, DNA replication, histone, methylation, phosphorylation, post translational modification, ubiquitination

Mol. Cells
Sep 30, 2022 Vol.45 No.9, pp. 603~672
COVER PICTURE
The Target of Rapamycin Complex (TORC) is a central regulatory hub in eukaryotes, which is well conserved in diverse plant species, including tomato (Solanum lycopersicum). Inhibition of TORC genes (SlTOR, SlLST8, and SlRAPTOR) by VIGS (virus-induced gene silencing) results in early fruit ripening in tomato. The red/ orange tomatoes are early-ripened TORC-silenced fruits, while the green tomato is a control fruit. Top, left, control fruit (TRV2-myc); top, right, TRV2-SlLST8; bottom, left, TRV2-SlTOR; bottom, right, TRV2-SlRAPTOR(Choi et al., pp. 660-672).

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