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Mol. Cells 2009; 28(3): 149-154

Published online September 17, 2009

https://doi.org/10.1007/s10059-009-0127-7

© The Korean Society for Molecular and Cellular Biology

Histone Modifications During DNA Replication

Karina B. Falbo, and Xuetong Shen

Received: August 31, 2009; Accepted: September 2, 2009

Abstract

Faithful and accurate replication of the DNA molecule is essential for eukaryote organisms. Nonetheless, in the last few years it has become evident that inheritance of the chromatin states associated with different regions of the genome is as important as the faithful inheritance of the DNA sequence itself. Such chromatin states are determined by a multitude of factors that act to modify not only the DNA molecule, but also the histone proteins associated with it. For instance, histones can be posttranslationally modified, and it is well established that these posttranslational marks are involved in several essential nuclear processes such as transcription and DNA repair. However, recent evidence indicates that posttranslational modifications of histones might be relevant during DNA replication. Hence, the aim of this review is to describe the most recent publications related to the role of histone posttranslational modifications during DNA replication.

Keywords acetylation, chromatin remodeling, DNA replication, histone, methylation, phosphorylation, post translational modification, ubiquitination

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Mol. Cells 2009; 28(3): 149-154

Published online September 30, 2009 https://doi.org/10.1007/s10059-009-0127-7

Copyright © The Korean Society for Molecular and Cellular Biology.

Histone Modifications During DNA Replication

Karina B. Falbo, and Xuetong Shen

Received: August 31, 2009; Accepted: September 2, 2009

Abstract

Faithful and accurate replication of the DNA molecule is essential for eukaryote organisms. Nonetheless, in the last few years it has become evident that inheritance of the chromatin states associated with different regions of the genome is as important as the faithful inheritance of the DNA sequence itself. Such chromatin states are determined by a multitude of factors that act to modify not only the DNA molecule, but also the histone proteins associated with it. For instance, histones can be posttranslationally modified, and it is well established that these posttranslational marks are involved in several essential nuclear processes such as transcription and DNA repair. However, recent evidence indicates that posttranslational modifications of histones might be relevant during DNA replication. Hence, the aim of this review is to describe the most recent publications related to the role of histone posttranslational modifications during DNA replication.

Keywords: acetylation, chromatin remodeling, DNA replication, histone, methylation, phosphorylation, post translational modification, ubiquitination

Mol. Cells
May 31, 2023 Vol.46 No.5, pp. 259~328
COVER PICTURE
The alpha-helices in the lamin filaments are depicted as coils, with different subdomains distinguished by various colors. Coil 1a is represented by magenta, coil 1b by yellow, L2 by green, coil 2a by white, coil 2b by brown, stutter by cyan, coil 2c by dark blue, and the lamin Ig-like domain by grey. In the background, cells are displayed, with the cytosol depicted in green and the nucleus in blue (Ahn et al., pp. 309-318).

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